Posted by admin on Feb 1, 2014 in |
The aim of this study was to evaluate the behavioural, muscle coordination and anxiolytic activities of methanolic extracts of Sophora interrupta (papilionaceae) in mice. The behavioural, muscle coordination and anxiolytic activities were evaluated by using various models of CNS using mice. Diazepam was used as standard drug for muscle coordination and anxiolytic studies. The extracts were administered orally at 400 mg/kg. The results of the present study indicates that the methanolic extract of Sophora interrupta leaves are effective in inducing a significant protection against behavioural, muscle coordination and anxiolytic activities, as evidenced by various CNS models with respect to control. This study confirmed the behavioural, muscle coordination and anxiolytic activities of this plant as it is used in traditional...
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Posted by admin on Feb 1, 2014 in |
The aim of the study was to develop sustained release matrix tablet of Losartan potassium and to evaluate its efficacy in reducing hypertension. In this experiment, sustained release matrix tablets were prepared by direct compression method and Methocel K4M CR and Methocel K100M CR were used as polymer. The evaluation involves three stages: the micromeritic properties evaluation of powder blend, physical property studies of tablets and in-vitro release kinetics studies. The powder blend was evaluated for angle of repose, loose bulk density, tapped bulk density, Carr’s index, Hausner’s ratio, moisture content and total porosity and the tablets were evaluated for hardness, friability, thickness, drug content and in vitro dissolution parameters. The weight variation was observed to be within the prescribed limits for each formulation. In vitro release studies were carried out using USP apparatus type II at 100 rpm and dissolution medium consisted of 0.1N hydrochloric acid for the first 2 hours and phosphate buffer pH 6.8 from 3 to 24 hours, maintained at 37±0.5°C. Drug release at different...
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Posted by admin on Feb 1, 2014 in |
In the present study maltose a polysaccharide was investigated as a promising carrier for colon specific drug delivery system. It was evaluated for pH change study, by using in-vitro and In-Vivo testing in Wistar rats. In-Vitro study shows that there is drop in the pH from 7.00 to 5.5 when incubated with ceacal content in the controlled condition. The In-Vivo experiment was carried out by administering maltose solution orally to the rats, which were sacrificed after six, seven and eight hours. Ceacal content was collected and pH was measured by using digital pH meter. The pH of ceacal content was not changed after oral administration of maltose which may be due to its absorption in upper G. I. Tract. To investigate maltose and ceacal content interaction and alteration of colon pH, the maltose spheres were prepared by extrusion and spheronization techniques and coated with different polymers to evade upper G. I. T. The developed coated maltose spheres were administered and evaluated for its pH change in same manner as...
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Posted by admin on Feb 1, 2014 in |
Background: Peptic ulcer is one of the common diseases affecting the mankind. Many studies reveal co-occurrence of both peptic ulcer and hypertension in humans. So, it might be beneficial to choose an optimal drug that will target both these conditions. The role of renin-angiotensin system in the pathogenesis of peptic ulcer is well known. AT receptor antagonists which prevent binding of AT-II to AT1 receptors, have been thought to be implicated in protection of gastric mucosa against development of ulcers. Objective: To study the antiulcer activity of telmisartan and candesartan in gastric ulcers induced by pylorus ligation method and indomethacin induced ulcer method in albino rats. Material and methods: Antiulcer activity of telmisartan and candesartan was tested against the standard antiulcer drug ranitidine, using two experimental gastric ulcer models; pylorus ligation method and indomethacin induced ulcer method using six albino rats for each drug and each ulcer model. Parameters used for studying the antiulcer activity were free and total acidity of the gastric contents in pylorus ligation method and...
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Posted by admin on Feb 1, 2014 in |
Pseudomonas aeruginosa FARP72 was isolated from the skin mucus of freshwater catfish (Clarias batrachus) as a potent antagonistic bacterium. Efforts have made to assess the antagonistic activity against potential fish and human bacterial pathogens in vitro. Antagonistic effects were confirmed by cross-streaking method against pathogenic bacteria such as Aeromonas hydrophila, Bacillus subtilis, Bacillus amylolequifasciens, Escherichia coli, Edwardsiella tarda, Klebsiella pneumoniae, Enterohaemorrhagic Escherichia coli (EHEC), Pseudomonas aeruginosa, Salmonella Typhi, beta haemolytic Streptococcus, Staphylococcus aureus ATCC12598and Vibrio cholera. The LD50 value of Pseudomonas aeruginosaFARP72 and β-haemolytic Aeromonas hydrophila N10P were calculated to be >5.65×1010 cells/ fish and 2.37×108 cells/fish, which proved them to be non-pathogenic and moderate pathogenic respectively. In biocontrol experiment, the Labeo rohita stocks which received a first 15 min dip in Pseudomonas aeruginosaFARP72 suspension containing 1×107cells/ml followed by another dip in β- haemolytic Aeromonas hydrophila suspension containing 1×105 cells/ml for 15 min and subsequently cohabited with healthy Labeo rohita showed 37% mortality; while 75% of the fish died when treated only with β- haemolytic Aeromonas hydrophila suspension containing...
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