Posted by admin on Dec 1, 2013 in |
The aim of this paper is to study the employee turnover ratio in an Indian pharmaceutical company in India. Primary data were collected from 50 employees of two pharmaceutical companies using questionnaire methods. The questionnaire data was grouped to produce a concise representation of the human resource turnover retention using hierarchical clustering (HC) technique. The results of HC have grouped the numerical questionnaire data into two groups named as push and pull factors. It is observed that the mean of the pull factors was higher owing to higher turnover intention of the employees. Hence, it is recommended to the organization to include these factors to be part of the organization business strategy rather than being left to HR managers to act in order to reduce the employee exits from the...
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Posted by admin on Dec 1, 2013 in |
Premna integrifolia Linn. roots are used in the Indian system of medicine for the treatment of diabetes, inflammation, liver disorders etc. The present study was aimed to investigate the antioxidant activity of Premna integrifolia L. (Family: Verbenaceae) in CCl4 (carbon tetrachloride) induced oxidative stress in Sprague- Dawley rats. CCl4 injection induced oxidative stress by a significant rise in thiobarbituric acid reactive substances (TBARS) along with reduction of superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione-s-transferase (GST) and glutathione reductase (GRD). Pretreatment of rats with different doses of aqueous and methanolic extract (250 and 500 mg/kg) significantly lowered TBARS levels in CCl4 treated rats. GSH and hepatic enzymes like SOD, CAT, GRD, and GST were significantly increased by treatment with the plant extracts, as compared to the CCl4 treated rats. The activity of the extracts at the dose of 500 mg/kg was comparable to the standard drug, silymarin (25mg/kg). The results showed that Premna integrifolia extracts protect liver from oxidative stress induced by CCl4 in...
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Posted by admin on Dec 1, 2013 in |
Herbal and natural products of folk medicine have been used for centuries in every culture throughout the world. Scientists and medical professionals have shown increased interest in this field as they recognize the true health benefits of these remedies. Spinach is a leafy green vegetable that came originally from south-western Asia and is now grown in most parts of the world. Scientifically it is known as Spincia oleracea Linn. (Family-Chenopodiaceae). It is a good source of the bioflavonoid quercetin with many other flavonoids which exhibits anti-oxidant, anti-proliferative, anti-inflammatory, antihistaminic, in addition to its many other benefits. Treatment with Spinacia oleraceae (200mg/kg body wt) decreases the immobility time against forced swim test and tail suspension test. Fluoxetine (30mg/kg, i.p) was selected as reference standard and it showed significant antidepressant activity in rodents. Results suggest that Spinacia oleraceae exerts anti-depressant activity as shown by its effects on different experimentally induced different...
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Posted by admin on Dec 1, 2013 in |
The present study was undertaken to explore the tumor take inhibitory effects of ethanolic extract of Murraya koenigii in rodents. Tumor take inhibitory activity was investigated in hybrid mice (of C57BL strain + Swiss albino strain). Preventive group animals were injected daily with the extract at dose of 50mg/kg body weight i.p. for 10 consecutive days. The animals were observed for the growth of tumor after injection of B16F10 melanoma cells into the dorsal skin of mice. Pretreatment with the extract and showed delay tumor growth by increasing the volume doubling time, VDT (p<0.01), growth delay, GD (p< 0.01) and mean survival time, MST (p<0.001). Tumor regression studies showed a regression response for tumor growth in vivo of murine mouse melanoma tumor cell lines, demonstrated by increasing the VDT and...
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Posted by admin on Dec 1, 2013 in |
Central pathogenic mechanism of Alzheimer’s disease (AD) involves aggregation of amyloid β (Aβ) protein to form toxic oligomers. Identifying novel small molecules that inhibit the aggregation of monomeric Aβ to toxic oligomeric species can be an effective disease modifying strategy for AD. In the present study, plants being used in Ayurveda for treating dementia as well as to improve memory and cognitive function have been considered. These included Nelumbo nucifera, Valeriana wallichii, Celastrus paniculatus, and Raulfia serpentina. We tested the efficacy of these plant extracts and some of their active ingredients for their anti-amyloidogenic property by means of in vitro aggregation studies. The effect of each extract or phytocompound was tested on inhibition of aggregation as well as dissociation of preformed aggregates using thioflavin T fluorescence assay and transmission electron microscopy. Of the compounds screened, β-sitosterol and valerenic acid prevented the aggregation of Aβ while α-asarone and glycyrrhizin were effective in dissociating the preformed aggregates. More importantly, all the four phytocompounds have conferred protection against Aβ mediated toxicity in...
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