Posted by admin on Dec 1, 2011 in |
In vitro dissolution of ten brands of diclofenac sodium sustained release matrix tablets were studied to determine the effect of fruit juice in the bioavailability of diclofenac. Significant reduction was observed in the release rate at all collected brands, where except sample D7 and D8 others were not fulfill the USP in vitro dissolution specification when administered with fruit juice. Therefore to avoid drug therapeutic failures and of the drug in the systemic circulation, ingestion of the juice with diclofenac sodium should be...
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Posted by admin on Dec 1, 2011 in |
Acebrophylline is a bronchodilator with mucosecrytolytic and anti-inflammatory activity. It is used to treat the bronchial asthma, and chronic obstructive pulmonary diseases. This work is based on the formulation and optimization of time dependant pulsatile release tablets of Acebrophylline having adequate mechanical strength of tablet and proper drug release of tablet. Pulsatile drug delivery system has an advantage as delivers the drug at right place, right time and right quantity. The crucial aspect in the formulation of pulsatile drug delivery system is to release the drug as pulse after a lag time has to be designed in such a way that rapid and complete drug release follows after lag time. Present work conceptualizes a specific technology, based on pulsatile principles to develop drug delivery system, intended for chronotherapy in bronchial asthma. This approach will be achieved by using a programmed delivery of acebrophylline. In this work rapid pulse to pulsatile drug delivery system can be achieved through immediate release tablet with good mechanical strength and proper disintegration. Lag time...
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Posted by admin on Dec 1, 2011 in |
Background and Objective: Malaria, a formidable global parasitic infection represent a major health problem in tropical countries in terms of geographical spread, high morbidity, severe mortality especially among children. This study investigated platelet function’s role and its strength to make platelet factor 3 (PF-3) available for coagulation in children with cerebral malaria. Subjects and Methods: Packed cell volume, platelet aggregate, platelet count and platelet factor-3 were studied in 65 children with, cerebral malaria and 50 healthy control children (Both group were aged 1-9 years). Results: Packed cell volume, platelet count were significantly lower (P<0.01) in children with malaria and platelet factor-3 was significantly higher (P<0.01) in children with cerebral malaria compared to normal children (controls). There was no significant level of platelet aggregate between children with cerebral malaria and control. Conclusion: Although the pathological roles of platelet function abnormalities in cerebral malaria infection is controversial but our study conclude that cerebral malaria infection is associated with thrombocytopenia and the increase of platelet factor-3 availability, with presence of platelet aggregates,...
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Posted by admin on Dec 1, 2011 in |
Tinospora cordifolia (Fam: Menispermaceae) has been investigated for evaluation of the biological activities. The stem of Tinospora cordifolia were extracted with carbon tetrachloride, n-hexane and methanol were collected and afford 4.0 mg, 4.0 mg, and 4.0 mg, respectively for the test. The crude carbon tetrachloride, n-hexane, and methanol extract of the plant were subjected to antimicrobial screening against 15 microorganisms such as gram-positive, gram-negative, fungi by the disc diffusion method. But interestingly no fraction showed any inhibitory effect against all the microorganisms. In the brine shrimp lethality bioassay, carbon tetrachloride fraction showed high toxicity, where LC90 value was only 6.25 mg/ml. The methanol crude extract and n-hexane fraction showed LC50 of 1.563 and 6.05 mg/ml respectively with very narrow therapeutic index (LC90 of 43.0 mg/ml and 45.0 mg/ml respectively. This indicated that the cytotoxicity exhibited by the carbon tetra chloride, n-hexane, and methanol extract was very...
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Posted by admin on Dec 1, 2011 in |
Artemisia pallens Walls. ex DC, commonly known as Davana, is an aromatic herb found abundantly in humid habitats in the plains all over India. Artemisia pallens is found in Nilgiri hills, and has been used by the tribal people for various ailments. It has been widely used in Indian folk medicine for the treatment of diabetes mellitus. This plant is accredited with antihelmintic, antipyretic and tonic properties and also considered as a good fodder. The oil possesses antispasmodic, antibacterial, antifungal and stimulant properties. The plant has been screened for the antimicrobial, antidiabetic, antinociceptive and wound healing activity. The current study deals with the Phytochemical and Pharmacological of Artemisia...
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