Posted by admin on Oct 1, 2011 in |
Diabetes is a chronic metabolic disorder characterized by altered carbohydrates, fat and protein metabolism, and an increased risk of vascular complications. Swiss albino mice weighing 20-25g and albino rats (Wistar strain) weighing 170-190g of either sex were used for the studies. Mice used for toxicity and rats for anti-diabetic study. The aqueous roots extract of Murva was found to be safe at a dose of 2000mg/kg; hence a dose of 800mg/kg was used for anti-diabetic study. Diabetes was induced by alloxan monohydrate 150mg/kg i.p. After three days of injection of alloxan, diabetes was confirmed by monitoring its blood glucose level. Animals with blood glucose level more than 200mg/dl were taken for studies. Glibenclamide 20mg/kg i.p was taken as std. drug. The test possessed significant anti-diabetic activity (p<0.001) when compared to positive and negative control. Hence the roots extract of Murva may be value in patients with diabetes...
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Posted by admin on Oct 1, 2011 in |
The different extracts of the roots of Caesalpinia Bondue (Family- Fabeaccae) were tested for anti-diabetic activity, by glucose tolerance test in normal rats and alloxan induced diabetic rats. Aqueous ethanol and chloroform extracts had shown significant protection and lowered the blood glucose levels to normal in glucose tolerance test. In alloxan induced diabetic rats the maximum reduction in blood glucose was observed after 3h at a dose level of 250 mg/kg of body weight. The percentage protections by aqueous chloroform and ethanol extracts were 22.28 and 23% respectively. In long term treatment of alloxan induced diabetic rats, the degree of protection was determined by measuring blood glucose, triglycerides, cholesterol and urea levels on 0,3,5,7 and 10th day. Both the extracts showed a significant anti- diabetic activity comparable with that of glibenclamide, standard anti-diabetic...
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Posted by admin on Oct 1, 2011 in |
The objective of the present study was to develop once daily controlled-release matrix tablets of Domperidone Maleate, an anti- emetic agent. Several formulations containing an anti- emetic agent (domperidone maleate) and hydrophilic polymers (Hydroxypropyl methylcellulose, Carbopol and Polyethylene oxide) were prepared by wet granulation methods. The tablets were subjected to thickness, diameter, weight variation test, drug content, hardness, friability and in-vitro release studies. All the tablet formulation showed acceptable pharmacotechnical properties and complied with in house speciation for tested parameters. The results of dissolution studies indicate that formulation FH2 (Drug to HPMC, 1:0.50; purified water as granulating agent) could extend the drug release upto 24 hours. All the formulation exhibited diffusion dominated drug...
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Posted by admin on Oct 1, 2011 in |
The aim of present study is to develop a delayed release pellets dosage form of duloxetine hydrochloride with a suitable polymer by using suspension layered method. Drug loaded nuclei was prepared using suspension layered technique in a Fluidized Bed Processor, the nuclei was coated with an acid resistant acrylic polymer (Eudragit L30-D55) and compared acid resistant properties with HPMC phthalate. The entire coating process performed in a Fluidized Bed Processor to different thickness. The in vitro dissolution studies were conducted in 0.1N HCl for 2 hours followed by phosphate buffer (pH 6.8) for 1 hour with USP dissolution tester (type II). The results generated in this study showed that proper selection of polymer material based on their physicochemical properties as well as polymer load is important in designing delayed release pellets dosage form with best fit of dissolution...
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Posted by admin on Oct 1, 2011 in |
Aim: Primary urinary bladder adenocarcinoma is a rare entity. This is a clinical case presentation with review of the literature on this topic. Primary adenocarcinoma of the urinary bladder has shown a poor response to radiation or chemotherapy individually. Therefore, combination chemotherapy with radical EBRT is the effective therapeutic approach for inoperable cases. Method: A 58 year old male patient referred to the department of Radiotherapy, Regional Cancer Centre, Pt. BDS PGIMS ROHTAK with complaints of gross painless hematuria, dysuria, burning micturation for 5 years. Diagnostic work-up included renal and bladder ultrasound, cystoscopy and CT scan of abdomen and pelvis. CT scan showed mass lesion in urinary bladder infiltrating anterior abdominal wall (primary bladder adeno- carcinoma T4bN0M0). Trans-urethral resection followed by tissue diagnosis revealed an invasive adenocarcinoma. Metastatic disease was ruled out. Patient responded completely to systemic combination chemotherapy including GEMCITABINE and CARBOPLATIN six courses followed by radical external radiotherapy. At 24 months of follow-up, the patient did not present disease progression or systemic complications, after that he developed a nodular lump in neck. FNAC of node showed...
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