Posted by admin on Jan 31, 2022 in |
Objective: The aim of the study was to develop osmotic tablets of nateglinide by two methods, namely elementary osmotic pump (EOP) and push-pull osmotic pump (PPOP) method for controlled drug release. Methods: Initially, pre-compression parameters were studies for the tablet blend in both EOP and PPOP methods. The tablets were prepared by the wet granulation method in both methods. The prepared tablets were evaluated for various physicochemical parameters, in-vitro dissolution, and the dissolution data were fitted into kinetic models for knowing the mechanism of drug delivery. The optimized formulation obtained in both methods was further characterized for FTIR and stability studies. Results: In EOP method, P1-P14 formulations prepared before coating exhibited 16h drug release, and after coating (F1-F14) all the formulations exhibited 24h prolonged drug release, with F14 showing the highest drug release of 98.82%. In PPOP method, in-vitro drug release depended on the effect of plasticizer, effect of drug layer to coating weight gain, and osmogen concentration. Finally, formulation FF14 was optimized with the highest drug release of 99.97%,...
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Posted by admin on Jan 31, 2022 in |
A new preorganized ligand, benzil bis [2-(2-amino-ethylamino) ethanol)] (H2BAE) has been synthesized and characterized for the first time. Copper (II) and cobalt (II) complexes of H2BAE have been synthesized and characterized based on molar conductivity data IR, UV-Vis spectroscopy. The complexes are found to have general formula M(BAE)2 (where, M = Cu (II) and Co (II). IR spectral data indicate that H2BAE acts as hexadentate ligand. The complexes are 6-coordinate and found to have octahedral structure; the copper complex is investigated using ESR spectroscopy at room temperature (RT) and liquid nitrogen temperature (LNT). The spin Hamiltonian, orbital reduction, and bonding parameters are calculated for the complex. The interactions of these complexes with calf thymus DNA have been investigated using absorption spectrophotometry. Groove binding of complexes to DNA is suggested on the basis of deoxyribonucleic acid (DNA) binding constants and the variations in the absorption spectra of metal complexes in the presence of DNA. The copper complex binds DNA more strongly than cobalt complexes. Metal complexes are screened for their...
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Posted by admin on Jan 31, 2022 in |
The main objective presents research work to synthesize, characterization, and in-vivo evaluation of Pyridazine derivatives. To study the different synthesized derivatives by using different analytical parameters like IR, Mass, and NMR analysis. And also find out the antihypertensive activity. The studies on the hydralazine group drugs led to the synthesis of many Pyridazine derivatives with a wide activity spectrum on the cardiovascular system. Pyridazine derivatives, a class of compounds containing the N-N bond, exhibit a wide range of pharmacological activities such as antidepressant, antihypertensive and cardiotonic etc. Some 7-phenyl-3, 4, 8, 9-tetrahydro-2H-pyridazino [1, 6-a] [1, 3, 5] triazin-2-imine were synthesized by reacting 6-Phenyl substituted 2, 3, 4, 5-Tetrahydro pyridazin-3-one with cyclic secondary amine under Mannich reaction conditions. The total seven compounds (vj1-vj7) were synthesized under Mannich reaction conditions. All the synthesized derivatives were selected for evaluation of antihypertensive activities by a non-invasive method using Tail Cuff method. Most of the compounds showed good antihypertensive activity. Few compounds like vj4, vj5, and vj6 were found to show a highly significant...
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Posted by admin on Jan 31, 2022 in |
Human beings always tried to protect their body from pathogenic microbes, whereas these pathogens always mimic and mutate themselves to infect humans. Nanotechnology is new and upgrading itself as well as enhancing its applicability in pharmaceuticals. Due to their nano-size structure, property drastically changes from their parent elements. Nanoparticles are used widely in biomedical sciences. Focusing on these perspectives, the present study investigates the impact of phyto-synthesized Zinc Oxide Nanoparticles (ZnO NPs) using Murraya paniculata leaf extracts. The characterization of synthesized ZnO NPs was 32 nm with a more optical stable showing peak value at 355 nm (UV-vis). Further, toxicological efficacy of ZnO NPs was checked against human pathogens viz., Salmonella typhimurium (causing typhoid), Staphylococcus aureus (causing tooth decay and rheumatic fever) and Escherichia coli (causing tooth decay in infants and dysentery). The anti-bacterial bioassay was done using a well diffusion method and compared with the standard drug streptomycin. The test pathogens were found more sensitive towards phyto- synthesized ZnO NPs with a Zone of Inhibition Diameter (ZID) value...
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Posted by admin on Jan 31, 2022 in |
The present research effort was undertaken to isolate phytoconstituents from pharmacologically active extracts of stem bark of Albizia stipulata based on in-vitro pharmacological screening and their subsequent characterization. Methods: Crude extracts of bark of Albizia stipulata were prepared using various solvents such as methanol, hydro alcohol, and water. These extracts were screened for in-vitro pharmacological activities like antioxidant, anti-inflammatory, and anti-diabetic activities. The active extract was subjected to column chromatography through a mixture of solvents to get fractions and eluted fractions were run in TLC using various mobile phases with different solvent ratios. The isolated compounds were subjected to IR, 1H NMR, 13CNMR and LC-MS spectral analysis for chemical characterization. Results: The methanol extract of bark of Albizia stipulata was potent compared to other extracts. This extract was subjected to column chromatography to get fractions, and eluted fractions were run in TLC. The fractions with similar Rf values to standard were united and crystallized. The spectral analysis confirmed that the isolated compounds were found to be β-Sitosteryl-3-O-β-D-glucoside and 3...
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