Posted by admin on Apr 30, 2025 in |
In the present era, plant derived green products are gaining a lot of importance due to their ecofriendly nature, unique chemical compositions and mode of action. In the present study, three varieties of Moringa oleifera, namely Shyama- black color variety (most found), Shveta – white color variety and Rakta – red color variety (less found) were used for the synthesis of biosurfactant, pectins and resins. The results of the study indicated that the varieties were good sources of pectin, showing that the samples could be efficiently used in many food processing industries as a gel forming, thickening agent and as a stabilizer. Natural resins were synthesized from the varieties of Moringa oleifera leaves. The results obtained from the present study showed that Moringa oleifera could be a potential source of plant derived resins with application in medicine and pharmacy as many plant resins have been observed to elicit pharmacological effects. Biosurfactants were obtained from the leaves of the plant samples thus proving to be suitable for the formulation of green products...
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Posted by admin on Apr 30, 2025 in |
Background: The emergence and spread of Vancomycin, Linezolid and combined linezolid/vancomycin resistance in Enterococcus species (LVRE) is a major therapeutic challenge. Vancomycin-resistant Enterococci are an important cause of healthcare-associated infections. Linezolid and Teicoplanin are currently approved for the treatment of VRE; however, resistance to these antimicrobials appears to be increasing. Aims/Objectives: The study was done to find the prevalence and to study the antimicrobial resistance pattern of Enterococci isolated from patients with bacteremia in a tertiary care hospital in Ahmedabad. Methodology: This retrospective study was conducted for a period of one year; Blood samples were received and incubated in Bact/Alert 3D automated blood culture machine. Positive indicated blood samples were cultured, and identification and antimicrobial susceptibility testing was done using both manual and automated methods. Results: In this study, 4147(35%) blood samples were found positive. Out of 4147 positive blood samples 278(6.7%) samples were shown growth with Enterococci species. Out of 278 Enterococci, 8(2.87%) Enterococci were found to have both linezolid and vancomycin resistance. Conclusions: Prevalence of LVRE is low...
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Posted by admin on Apr 30, 2025 in |
This study investigated the efficacy and safety of three herbal decoctions for managing Polycystic Ovary Syndrome (PCOS), a condition affecting 2–26% of women globally and considered incurable within allopathic medicine and offers symptomatic treatments. This randomized, single-blind clinical trial, conducted between February 2022 and June 2024, enrolled 90 PCOS patients diagnosed by the Rotterdam (2003) criteria. Participants were randomly allocated into three intervention groups: Nigella sativa (Arm I), Sesamum indicum (Arm II), and a combination of both (Arm III). Each group received 30 ml of the assigned decoction twice daily over three months. Clinical parameters were assessed using established grading scales, including androgenic alopecia, hirsutism, acne, and acanthosis nigricans. Additionally, ultrasound scans (USS) were performed pre- and post-treatment to evaluate changes in ovarian morphology. Results indicated a significant reduction in ovarian volume for Arms I (P=0.029) and II (P=0.008) and an increase in follicle size across all three arms. The number of participants with polycystic ovarian morphology significantly decreased in Arm I (P=0.016) and II (P=0.004). However, one-way ANOVA...
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Posted by admin on Apr 30, 2025 in |
Objective: Sunitinib malate is an oral, potent multi-targeted TKI that displays antitumor and anti-angiogenic actions. The core focus of the present research work is to establish an innovative QbD-based analytical method for the estimation of Sunitinib malate in solid dosage form by ultra-high performance liquid chromatography (UHPLC). Materials and Methods: The change in independent variables, wavelength, flow rate and Acetonitrile concentration with response to retention time, area and tailing factor were studied using Box-Behnken design. Chromatographic separation was accomplished by using XBridge shield RP18 (50mm x 3mm, 2.5μm) column, flow rate was adjusted to 0.7mL/min. at a temperature of 25ºC. The detection was carried out at 388nm with a run time of 5 min. Results and Discussion: The retention time of Sunitinib malate was found to be 2.391 min. The method is robust, accurate and precise, as depicted by the statistical data of analysis. The correlation coefficient was found to be 0.999. The solution was found to be stable for 24 hours at 250C. Hence the current research work...
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Posted by admin on Apr 30, 2025 in |
Background & Objective: India is home to two infectious diseases caused by Salmonella: typhoid and paratyphoid fever. The medication of choice for S. typhi is ceftriaxone, a third-generation cephalosporin. Study was carried out on the Surveillance of Enteric Fever in India to ascertain the prevalence, clinical manifestation, and trajectory of antimicrobial resistance (AMR). This work aimed to examine the antibiogram profiles of Salmonella typhi found in patient blood cultures. Second, to record how often Salmonella typhi infections occur located in Vadodara, the Antibiotic Susceptibility Test is third. Material and Methods: The Retrospective study was carried out over a period of 12 months after obtaining ethical approval. The freshly drawn venous blood was placed in a blood culture vial. Following identification of pathogen isolates, Kirby-Bauer disc diffusion test was employed to determine antibiotic drug susceptibility as per CLSI rules. Results: Total 10,126 blood samples were collected. In 84 samples (0.83%), 83 instances of Salmonella typhi and 1 instance of Para typhi B. The ratio of males to females was 1:2....
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