Posted by admin on Oct 31, 2025 in |
Worldwide, hypertension represents one of the most common complications of pregnancy. Hypertensive disorders continue to occur globally, complicating 5-20% of pregnancies. Its incidence varies from 2 to 8% of pregnancies in developed countries reaching 10% or more in developing countries. Hypertension in pregnancy is defined as systolic blood pressure (sBP) ≥ 140 mmHg and/or diastolic blood pressure (dBP) ≥ 90 mmHg, or by ↑ in sBP ≥ 30 mmHg, or in dBP ≥15 mmHg from preconception or first trimester blood pressure confirmed by two measurings 6 hours apart. It is associated with high rates of perinatal morbidity and mortality and is the third most common cause of maternal death worldwide. The present study was designed to analyze the physicians prescribing pattern of various antihypertensives, a drug utilization study of both qualitative and quantitative variants, also describing physician’s compliance with existing guidelines. The greatest challenge in treating hypertension in pregnancy is to reduce the blood pressure to assure the safety of mother and at the same time not to compromise...
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Posted by admin on Oct 31, 2025 in |
To estimate Tolnaftate in the presence of its forced declination products, a straightforward and quick stability indicating High Performance Thin Liquid Chromatography -Photo Diode Array (HPTLC-PDA) approach was created and validated. The methodology used Toulene: Chloroform: Methanol (311 v/v) as mobile phase and SunQSil C18 column (250mm×4.6mm, 5µm) as stationary phase. Retention time of tolnaftate was found to be 0.27 minutes. To assess the declination conduct of tolnaftate, examinations into acid, alkali, oxidative, UV declination and thermal declination were conducted. In agreement with the criteria of International Conferences on Adjustment (ICH), the created and optimized approach was validated. The results showed that the limits of quantitation and discovery were 0.421 and 0.088µg/mL, singly. With R2=0.9991, linearity was seen in the attention range of 0.276-6µg/mL. Results showed the recovery ranged from 98.2 to 101.01. Reversed 7 Phase -High Performance Thin Liquid Chromatography (RP-HPTLC), a developed and tested technology was used to quantify tolnaftate in an in-house topical result. The main products of Oxidative and Base declination were discovered and described...
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Posted by admin on Oct 31, 2025 in |
Diabetes mellitus – Type 2 Diabetes Mellitus (T2DM) in particular – is a long-term inherent metabolic disorder that is seriously problematic with regards to global health. Sulfonylureas are a class of widely-used oral hypoglycemic drugs aimed at type 2 diabetes mellitus, targeting ATP-sensitive potassium channels through sulfonylurea receptor 1 (SUR1). This study intends to design and evaluate novel sulfonylurea derivatives via in-silico models in order to enhance both therapy potential and drug-likeness. Molecular docking studies were conducted with AutoDock 4.2.6 against the protein 4EM9 (PPARγ). This is a critical target for T2DM, along with the most established relative glibenclamide for comparison. Docking scores indicated that all derivatives (1a-1d) had strong binding affinities but ligand 1a showed the most affinity with a value of -7.48 kcal/mol. ADME profiling via Swiss ADME gave good pharmacokinetics and bioavailability data, while the suitability of drug likeness got confirmed by Molinspiration and PASS prediction. All this helps in proving the sulfonylurea derivatives-another promising one being 1a-as important drug candidates to treat...
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Posted by admin on Oct 31, 2025 in |
Plants have evolved to produce a vast array of natural compounds with significant health-promoting properties. Medicinal plants remain crucial resources for contemporary drug discovery and development. This study presents the first scientific investigation into the medicinal potential of Syzygium tamilnadense (Rathakr & Chitra), a rare and endemic species of the Myrtaceae family native to the Sholur–Nanjanad Reserve Forests in the Nilgiri Biosphere, Western Ghats, Tamil Nadu, India. Various solvent extracts were prepared, with ethanol yielding the highest concentration of phytochemicals. Preliminary phytochemical screening revealed the presence of alkaloids, flavonoids, catechins, coumarins, glycosides, phenols, saponins, steroids, tannins, terpenoids, sugars, and xanthoproteins compounds known for their diverse pharmacological activities. Quantitative analysis showed high contents of total phenolics (128.14±0.76mg GAE/g), flavonoids (44.20±0.28mg QE/g), and tannins (38.26 ± 0.48 mg QAE/g), indicating strong antioxidant capacity. Gas Chromatography– Mass Spectrometry (GC–MS) analysis identified 25 bioactive compounds, including caryophyllene oxide, neophytadiene, squalene, phytol, and linoleic acid ethyl ester, which are associated with antioxidant, anti-inflammatory, antimicrobial, and anticancer properties. These findings highlight S. tamilnadense as novel...
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Posted by admin on Oct 31, 2025 in |
Sulphacetamide is a sulfonamide antimicrobial widely used in injectable formulations for ocular and systemic bacterial infections. However, its chemical sensitivity to environmental factors poses a significant challenge for formulation stability, requiring a comprehensive impurity profiling approach. The current study aimed to develop and validate a stability-indicating UPLC-ESI-MS/MS method for the identification and characterization of impurities and degradation products of Sulphacetamide under various stress conditions in accordance with ICH Q1A (R2) guidelines. Forced degradation studies were performed by subjecting Sulphacetamide to acidic, basic, oxidative, thermal, and photolytic stress. Chromatographic separation was achieved using a BEH C18 column with an optimized mobile phase under gradient elution. Mass spectral data were acquired using electrosprayionization in positive mode, enabling structural elucidation of degradation products based on fragmentation patterns and m/z values. The method showed excellent specificity, sensitivity, and resolution for Sulphacetamide and its impurities. Major degradation was observed under acidic and oxidative conditions, yielding characteristic fragments such as m/z 131.38, 149.54, 200.02, 325.42, and 425.72. Minor degradation was noted under basic conditions, while...
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