Posted by admin on Dec 31, 2016 in |
Although technologies are emerging day to day and bioinformatics is also growing with number of databases developed, but being a very important factor in cancer invasion and metastasis, MMPs have no exclusive database. Matrix Metallo-Protienase (MMP) is a major class of proteolytic enzymes that plays a dominant role in ECM degradation. Every time researchers are searching and gathering information from different places and next researcher repeating the same. In this study we developed a database exclusively designed for the MMPs and their...
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Posted by admin on Dec 31, 2016 in |
This study aimed to evaluation of healing potential of Sambucus ebulus in full-thickness wound model in rats. A dorsal skin wound was created in rats. The 5% ointment applied to the wound area once a day for 12 days. Healing process was compared histologically between the groups. Parameters of wound healing were evaluated in the wound area. Extract improved wound contraction and closure. Histopathology study certified an organization of wound tissues. Extract reduced the number of inflammatory cells, increased wound-healing rate, epithelialization and significantly improved collagen formation. Granulation tissue formation was more organized when compared with control groups. S. ebulus showed positive effects on wound healing process and improved healing...
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Posted by admin on Jan 1, 2016 in |
The present investigation studied a novel bilayer tablet having extended release of rosuvastatin calcium (RSTCa) and immediate Release of fenofibrate (FB) in different polymers using wet granulation techniques. Granules were characterized by fourier-transformed Infrared Spectroscopy (FT-IR), differential Scanning Calorimetry (DSC), as well as by content uniformity, in-vitro dissolution studies and release kinetics. Selected granular system was subjected to bilayer tablet preparation by direct compression. Compressed tablets were evaluated for drug content, weight variation, friability, hardness, thickness, %assay and in-vitro dissolution studies. Prepared tablets were then coated and coated bilayer tablets were evaluated for the same. Functional groups of RSTCa and FB were retained in respective granules, suggesting absence of chemical interaction with any of the excipients used in the preparation of granules. Absence of specific peaks in physical mixtures revealed that FB has been completely converted to molecular form. Among the polymers used to improve drug release, MCC and HPMC K4M showed better control over drug release. Formulated bilayer tablets gave satisfactory results for various physicochemical evaluations and best...
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Posted by admin on Jan 1, 2016 in |
Objectives: To know the effects of chewing the fennel and cardamom seeds on plaque and salivary pH. Materials and Methods: 50 subjects (aged 18-60 years) attending V.S dental College and Hospital who gave consent to participate were recruited for this clinical study. Subjects were randomized in to two groups for chewing fennel and cardamom seeds. Salivary pH and plaque PH at baseline and immediately after chewing seeds for 5 minutes and after 10 min was measured using calibrated glass combination electrode and analysed by ANOVA. Results: The mean salivary PH scores at baseline, immediately and 10 minutes after chewing fennel seeds was 7.1, 7,3 and 7.5 (p value 0.001). The mean salivary PH scores at baseline, immediately and 10 minutes after chewing cardamom seeds was 7.4 , 7.6 , 7.76 (p<0.05). The mean plaque pH scores at baseline, immediately and 10 min after chewing fennel seeds was 7.4, 7.55, 7.53 (p value 0.001). The mean plaque pH scores at baseline, immediately and at 10 min after chewing cardamom seeds...
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Posted by admin on Jan 1, 2016 in |
Microalgal like Chlorella vulgaris, being a unicellular green algae, is been widely studied for nitrogen and phosphorus removal and as potential feedstock for biodiesel production. This not only saves water from eutrophication but also becomes a good source of biodiesel. Hence, if two approaches are combined we can overcome the major challenge of both eutrophication and energy crisis. In the present study we have examined the effect of decreasing Nitrogen and phosphorus concentration in medium on growth, biomass and lipid content of C. vulgaris. Significant decrease in growth and biomass was observed with the decrease of nitrogen and phosphorus concentration in the medium from (1.5g/l to 0.0g/l) and (0.04g/l to 0.0g/l) respectively. Whereas the lipid accumulation showed reverse trend of increase when the concentration of both phosphorus and nitrogen where decreased in medium. At the same time, the effect of variation in pH and saline ranges on growth, biomass and lipid content of C.vulgaris were also evaluated. The growth, biomass and lipid content showed a significant difference due to...
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