Posted by admin on Dec 31, 2025 in |
According to the World Health Organization (WHO), cancer is the second leading cause of death globally, following ischemic heart disease. As of 2020, cancer accounted for approximately 10 million deaths-equating one in six worldwide. Although many cancers can be cured if detected early, but conventional chemotherapy faces serious limitations, including systemic toxicity, poor selectivity, and damage to healthy tissues. These challenges have spurred the development of more targeted and effective therapeutic strategies. Biodegradable nanocarriers have emerged as a promising advancement in cancer therapy. By enabling site-specific drug delivery, they significantly reduce toxicity and resistance while maximizing the pharmacological action at the tumor site. Their biodegradable nature ensures that they break down into non-toxic by products within the body, offering additional biocompatibility advantages. However, the application of nanocarrier-based therapies presents its own set of challenges. Designing nanoparticles with the optimal size, shape, and appropriate inner and outer layers tailored to specific cancer types remains a complex task. Overcoming these obstacles requires advanced approaches, including the development of massively parallel pooled...
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Posted by admin on Dec 31, 2025 in |
Beta-lactam antibiotics remain essential in treating bacterial infections due to their broad-spectrum efficacy and low toxicity. However, the increasing prevalence of beta-lactamase-mediated resistance, particularly among multidrug-resistant Gram-negative bacteria, undermines their clinical effectiveness. Recent advances in structural modification and new beta-lactamase inhibitors, such as Cefiderocol, Avibactam, Relebactam, and taniborbactam, have shown promising results against resistant pathogens like Carbapenem-resistant Enterobacterales and Pseudomonas aeruginosa. Structure-activity relationship (SAR) studies significantly improved antibiotic stability, bacterial membrane penetration, and resistance evasion. Innovative approaches, including monocyclic beta-lactams and siderophore-conjugated antibiotics, further expand therapeutic options. Additionally, targeted modifications against penicillin-binding proteins have enhanced beta-lactam efficacy. Despite these improvements, challenges persist, notably variability in therapeutic drug monitoring (TDM), limited inhibitor spectrums, and rapid resistance emergence. Future research should prioritize developing broad-spectrum, irreversible beta-lactamase inhibitors with optimized pharmacokinetics and minimal adverse effects, to maintain beta-lactams as effective tools against antimicrobial...
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Posted by admin on Dec 31, 2025 in |
Navamani Chenduram (NC) is one of the metallic preparations mentioned in the classical Siddha literature “Sikitcha Rathina Deepam” which is indicated mainly to treat female reproductive diseases like amenorrhea, ovarian tumor and ascites. Preparing the Trial drug in accordance with the standard operating procedure and put through a number of studies to ensure its safety, effectiveness, purity, and quality. WHO has highlighted the necessity of employing contemporary methods to guarantee quality control of Indian medicines. The aim of the study was to standardize the NC through Sophisticated instrumentation techniques like Inductively Coupled Plasma – Optical Emission Spectroscopy (ICP-OES), Fourier Transform Infra-Red (FTIR), Scanned Electron Microscopy with Energy Dispersive X-Ray Analysis (SEM EDAX) and X-ray Diffraction (XRD) for the detection of Functional group, Chemical, Elemental analysis, Particle size, Heavy metals analysis and Minerals present in NC. Also identified the drug substance forms and determine its molecular structure. The results showed that under ICP OES Heavy metals like Aluminum, Arsenic, Copper, Magnesium, and Mercury were found below the detection level. The...
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Posted by admin on Dec 31, 2025 in |
Background: Nephrotic syndrome is a kidney disorder characterized by heavy proteinuria, hypoalbuminemia, and often hyperlipidemia. Thyroid hormones play a crucial role in growth, development, and overall metabolic function. In the circulatory system, these hormones are primarily bound to specific proteins for proper distribution and regulation throughout the body. The substantial loss of these binding proteins innephrotic syndrome may lead to a reduction in circulatory levels of thyroid hormones, potentially resulting in a hypothyroid state. We conducted this study to find out the prevalence of hypothyroidism in pediatrics patients in Barpeta region of Assam, India. Methods: An observational, cross-sectional study of 67 patients was conducted, admitted in the Department of Pediatrics, diagnosed with nephrotic syndrome fulfilling the inclusion criteria were enrolled. Consecutive sampling method was used. Statistical analysis was performed using SPSS software (version 21.0). Categorical data was expressed as frequency and percentage, while continuous data was expressed as mean and standard deviation. Results: Hypothyroidism was present in 32.8% of cases and no statistically significant difference in hypothyroidism prevalence was...
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Posted by admin on Dec 31, 2025 in |
Background: Human Metapneumovirus (HMPV) remains a significant respiratory pathogen without specific antiviral therapy. Traditional Ayurvedic formulations like Dabur Chyawanprash, composed of numerous medicinal plants, may harbor bioactive compounds with antiviral potential. This study explores phytochemicals from Chyawanprash alongside FDA approved drugs; Ribavirin, Penicillin V and Ibuprofen for their suitability as antiHMPV agents using in-silico approaches. Materials and Methods: A total of 41 medicinal plants were screened, and their phytochemicals evaluated using SwissADME for pharmacokinetic profiling and ProTox-II for toxicity prediction. Compounds with favorable ADMET properties were docked against five essential HMPV targets: polymerase phosphoprotein complex (6U5O), prefusion closed trimer (8W3Q), M2-1 tetramer (4CSA), prefusion trimer (8VT3), and N-P complex (5FVD). Docking was performed using AutoDock Vina interphase of PyRx, and molecular interactions were analyzed via Discovery Studio. Results: Seven phytochemicals met ADMET and drug likeness criteria, with propanoic acid and 1-butanol demonstrating optimal GI absorption, BBB permeability, and non-toxic profiles. Among targets, Penicillin V and Ribavirin exhibited the strongest binding, particularly with the N-P complex (-7.7 and -7.2 kcal/mol)....
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