Posted by admin on Dec 31, 2025 in |
Respiratory Allergic Disorders (RADs), including asthma and allergic rhinitis, are increasingly prevalent, especially among children, and significantly affect quality of life. The limitations of conventional therapies in ensuring long-term relief have prompted the search for alternative remedies. Ayurveda attributes RADs to vitiation of Vata and Kapha doshas and considers impaired immunity due to Ama formation as a key pathological factor. Vyaghri JeerakaAvaleha, an Ayurvedic polyherbal formulation comprising Solanum surattense (Vyaghri), Cuminum cyminum (Jeeraka), Emblica officinalis (Amalaki), and Madhu (Honey), offers a multifaceted approach to the management of RADs. This review compiles pharmacological and Ayurvedic evidence highlighting the formulation’s anti-asthmatic, bronchodilatory, antitussive, anti-inflammatory, and immunomodulatory effects. Vyaghri exhibits bronchodilatory and anti-histaminic properties, while Jeeraka and Amalaki contribute to immune modulation and digestive stimulation, potentially addressing gut dysbiosis often linked with allergies. Madhu enhances bioavailability and contributes anti-inflammatory benefits. Together, these ingredients synergistically work through Rasayana (rejuvenation), Deepana (appetizing), Pachana (digestive), and Vata-Kapha-hara actions to alleviate symptoms and reduce recurrence of RADs. This integrative review supports the potential of Vyaghri JeerakaAvaleha...
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Posted by admin on Dec 31, 2025 in |
Background: The emergence of antimicrobial resistance (AMR) among different microbial species increases mortality and morbidity rates and makes healthcare services unaffordable. The pace in acquiring resistance to antimicrobial agents stresses the dire need for novel drug discoveries and defining new drug targets. Objectives: The present study aimed to isolate and identify the fungi from pharmaceutical waste sites, their antifungal profiling and characterization as potential antibiotic producers. Methods: Fungal isolates were primarily screened for antibiotic production following the giant colony method against standard bacterial pathogens and further screened to evaluate their capacity as extracellular antibiotic producers. Antifungal susceptibility testing to commonly prescribe antifungal agents was also performed for the recovered fungal isolates. Result and Conclusion: Total fifteen (n=15) fungal isolates recovered including Aspergillus sp., Alternaria sp., Candida sp., Rhizopus sp., Geotrichum sp., Rhodotorula sp., Pyricularia sp., Trichosporon sp., Trichothecum sp., and Fusarium sp. Cell-free supernatant (CFS) obtained from Geotrichum sp., Fusarium sp. and Trichosporon sp. were extracellular antibiotic producers with maximum zone size of 22mm, 16mm and 14mm respectively against...
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Posted by admin on Dec 31, 2025 in |
The most serious health issues facing the world today are blindness and vision impairment, which have a significant financial and societal cost. Delivering drugs to specific ocular regions is challenging due to the eye anatomical and physiological elimination mechanisms. When drugs are instilled to the eye using traditional delivery systems, their ocular bioavailability is low. These methods can avoid the ocular obstacles that currently limit the effectiveness of conventional therapies. They can also provide a longer-lasting release of the drug, which reduces dosing frequency and improves patient compliance. Drug delivery techniques based on nanotechnology, including micelles, nanosuspensions, nanoparticles, colloidal emulsions, niosomes and cubosomes offer efficient alternatives to conventional eye therapy. These devices are being used to study treatments for conditions affecting the anterior portion of the eye. The several delivery methods based on nanotechnology that are being researched for the treatment of anterior eye disorders are covered in this paper. The present and promising advancements in in-situ gelling as a means of delivering ocular medication were reviewed and summarized...
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Posted by admin on Dec 31, 2025 in |
On computers, in-silico studies are typically carried out where we forecast how any new compound would interact with the proteins found in our bodies or with any outside particles. Molecular docking, target site & adverse reaction of any newly created molecule, together with cell simulation, are all performed in an in-silico study. The advantage of in-silico research over other techniques is that it does not require the use of people, animals, or cell cultures; all that is required is a computer with the required software. In-silico analysis developed into one of the most crucial tools for all scholars throughout the world during the Covid -19. Results of any research project in an in-silico study are available immediately because of the utilisation of computers. Through the in-silico technique, research work is made incredibly simple. Understanding how any new drug will affect us, including its absorption, distribution, metabolism, excretion, and toxicity, is incredibly convenient for us. It is easier for us to predict the target location for each new molecule by...
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Posted by admin on Dec 31, 2025 in |
Lutein, a xanthophyll carotenoid found in most of the leafy greens and medicinal plants, promotes eye health by filtering blue light and reducing oxidative stress. It gathers in the macula, helping shield the eyes from conditions like age-related macular degeneration, cataracts, and diabetic retinopathy. This review compiles information from databases such as Google Scholar, PubMed, ScienceDirect, and ResearchGate. Studies indicate that lutein supplementation enhances contrast sensitivity, boosts macular pigment density, and supports retinal function, particularly in those with age-related macular degeneration. Beyond ocular benefits, lutein demonstrates neuroprotective, anti-inflammatory, and antioxidant properties, supporting cognitive function and skin health. Studies indicate that lutein is generally safe, even at higher doses, with no significant adverse effects reported. This review highlights lutein’s broad health benefits and emphasizes the need for further research to determine optimal intake levels. Including lutein-rich foods or supplements in daily nutrition can support long-term health and wellness essential for body...
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