Posted by admin on Dec 31, 2021 in |
Even if there are so many diagnostic tests available for the detection of tuberculosis, still the diagnosis of TB is a challenging problem in this decade due to differences or non-specificity in symptoms, radiological signs, false negatives, and positives. Chest X-ray can identify the location, area, and morphology of lesions; hence analyzed the pattern and relation of chest X-ray and Gene expert results. This was a retrospective observational study conducted in the Ernakulam district of Kerala, India. The study included both drug-resistant and sensitive patients in two groups from the period 2016-2019 and 2017-2019. The study excluded HIV patients from both groups. Only professionally interpreted data were entered into the study analysis. All privacy and confidentiality were ensured throughout the study under direct observation of the district TB center. The left lung was more affected in DS-TB (76.47%), and the right side was more infected in DR-TB (65%). The predominant infiltration (24.21%), cavity (22.22%), and Non-homogenous opacity (26.47%) were seen in the left middle zone, whereas consolidation (24.63%) was...
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Posted by admin on Dec 31, 2021 in |
Characteristics like dementia, behavioural and cognitive dysfunction, and memory decline may characterize Alzheimer’s disease (AD). A deterioration of short-term memory, inability to acknowledge new information, mood swings, difficulty recognizing words, forgetting names, and losing things are demonstrated by early disease. Popular emotional characteristics displayed by patients with AD are anger, aggression, and irritability. Today’s world attempts to treat various ailments have increased with medical advancements. There is still considerable research into medications capable of preventing or at least effectively altering the trajectory of AD, referred to as ‘disease-modifying medicines. Laboratory animals are helping to test new ways of treating illness. For the goal of developing therapeutics or disease-modifying agents, a vast array of experimental models were developed to simulate the human context of the illness. In animal studies, AD caused by chemical compounds may be helpful in deeper understanding the mechanism of disease and AD treatment. The anticholinergic drug Scopolamine induces amnesia in rodents. This analysis examines the various animal models frequently used to research the effect of novel...
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Posted by admin on Dec 31, 2021 in |
Objective: Mako (Solanum nigrum L.), Black Nightshade in English, belongs to the family Solanaceae is an edible plant. The whole plant is used as a green source of vegetables and berries as a fruit. It is a good source of antioxidant and has potent anti-inflammatory, diuretic, lithotriptic, wound healing properties. Unani scholars have advocated the berries to treat many renal ailments, including renal failure. The aim of this study was to evaluate the nephroprotective activity of the berries of Mako on gentamicin-induced nephrotoxicity in rats to authenticate the traditional claims. Materials and Methods: Wistar rats were divided into eight groups of six animals in each, group I – control, group II toxicant (gentamicin) and III–VIII were high dose (800 mg/Kg) of methanolic extract (ME), low dose (200 mg/Kg) of ME, Petroleum soluble fraction, chloroform soluble fraction, water-soluble fraction and water-insoluble fraction of ME, respectively. Test drugs were administered from day 1 to 8 along with toxicant from day 4 to 8. Results: At the end of the study, blood...
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Posted by admin on Dec 31, 2021 in |
Seaweeds are potential sources of bioactive molecules. They are known to be rich sources of proteins, carbohydrates, lipids, vitamins, minerals, and other secondary metabolites. To evaluate the presence of these compounds in marine macroalgae collected from Veraval coast of Gujarat, present studies was carried out. The methanol extract of six macroalgae species (Ulva lactuca, Ulva faciata, Acanthophora dendroides, Gracilaria corticata, Padina tetrastromatica, and Cystoseira indica) was subjected to LCMS/MS analysis which suggested presence of amino acids, sugar, vitamins and phytohormones in algae extracts. The aminoacids and vitamins present in Ulva lactuca (betaine, L-methionine, L-asparagine), Ulva faciata ( L-arginine, L-proline, L-histidine, L-valine, L-Threonine, Dihydrofolic acid), Acanthophora dendroides (L-glutamic acid, L-alanine, L-serine, L-phenylalanine, L-tyrosine, nicotinic acid), Gracilaria coeticata (L-canavanine, L-isoleucine, and L-cysteine) and Padina tetrastromatica (L-Aspartic acid, L-leucine) can be utilized for the development of dietary supplements and proteinaceous food for domestic animals. The sugar present in Ulva faciata (glucosamine), Acanthophora dedroides (D-xylose, D-mannose, D-fructose), Gracilaria corticata (D-Rhamnose, fucose, D-galactose), Padina tetrastromatica (D-glucuronic acid, D-glucose, D-mannuronic acid), and Cystosera indica (arabinose,...
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Posted by admin on Dec 31, 2021 in |
Tissues can be preserved for centuries under the conditions of extremely cold temperatures along with the neurological functions of the human brain. It is possible with the process of vitrification; here the cells of the brain are cooled to the cryogenic temperature without the formation of ice. Damage caused due to this process is theoretically reversible as like before, but practically, rejuvenation is possible only by the foreseeable technology which is specific. Injury caused to brain because of low or stopping of blood flow which is as a result of complex series of process which takes more than 6min of time to complete the limit of resuscitation technology. Damage of blood vessels occurs first then the brain tissues if the process of rejuvenation occurs for more than 6 min. For permanent death of neurons, many hours are required. The process of cryopreservation provides a chance for resuscitation by having an opportunity between legal death and permanent loss of life in both humans and animals. At appropriate conditions, the time...
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