Posted by admin on Dec 31, 2021 in |
SARS-CoV-2 viral cause infection called COVID-19 was initially reported in China has resulted in a pandemic because it has spread in over 210 countries. This review summarized pathophysiology, clinical features, diagnosis, and COVID 19. The spread of SARS-CoV-2 viral infections is a matter of concern because of a mutant variant of virus. The COVID-19 infection is having 14 days incubation period. Fever, sore throat, cough, severe headache, breathlessness, myalgia and weakness are common symptoms observed in patients with COVID-19. Steps of replication of SARS-CoV-2 virus are attachment, penetration, uncoating, replication, assembly and release. Patients’ screening tests are complete blood count, C-reactive protein (CRP) and erythrocyte, sedimentation rate (ESR), D-dimer, serum ferritin, and others. The reverse transcription-polymerase chain reaction (RT-PCR) is the important diagnostic test of molecular genetic assays for detecting viral RNA. In-Patient of COVID 19 CT scan shows ground-glass opacities with or without consolidations in lung regions. In CT scan, standardized assessment scheme is CORAD classification and assessment of lung involvement can be done CT severity score index....
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Posted by admin on Dec 31, 2021 in |
Medical Case taking process in any field of medicine science is considered to be a significant stage for the treatment management of various diseases. Cardio Vascular diseases (CVD) are one of the life-threatening diseases across the globe, and its prognosis entirely depends on the right intuition of the clinicians; cases may account for 31% of deaths worldwide, based on a recent study. Big Data Management and Machine Learning Algorithms have reached paramount Computational Technological advancement over the last decade and capable of drive applications in diverse domains which can assist in the process of selecting proper medicines. The case-taking approach and selection of drugs were significantly correlated, and the skill of the physicians plays a very important role in the entire procedure blended with proper use of Smart Technology, Artificial Intelligence, and Cloud storage of huge volume of patient’s physiological, clinical and pathological data. In this paper, we have made an attempt to build a digital system driven by smart technology to cater to this equation and explore the...
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Posted by admin on Dec 31, 2021 in |
Oral administration of 131I to the patients of differentiated thyroid cancer is routinely used to ablate remnant thyroid tissue or metastasis. In 30% of the patients, permanent salivary gland damage due to therapeutic 131I exposure results in xerostomia, affecting their quality of life. Amifostine is the only standard FDA-approved radio protect ant available for damage control, albeit associated with side effects such as hypotension and allergic reactions. The present study was carried out to compare the radioprotective effect of O. sanctum extract with that of a standard radio protectant, amifostine in salivary glands of the rabbits exposed to high dose (1GBq) of 131I internal radiation exposure. The study parameters included were salivary amylase, serum SGOT and SGPT, haematological parameters, 99m Technetium pertechnetate scintigraphy study, histopathology and ultrastructure of the salivary gland. The experimental rabbits were sacrificed after 6 months of 131I exposure. The experimental observations, majorly histopathological and electron microscopic are suggestive of better preservation of cell morphology and ultrastructure after O. santum as well as amifostine pre supplementation....
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Posted by admin on Dec 31, 2021 in |
Urena lobata is used by traditional practitioners for treating external wounds. A preclinical study was conducted to evaluate the efficacy of the ointment formulations containing ethanolic extract of Urena lobata (EO) (5%) and nanosized extract (NO) of U. lobata (5%) for their wound healing activity by assessing wound contraction, tensile strength, superoxide dismutase, catalase, reduced glutathione, myeloperoxidase, hydroxyproline, lipid peroxidation and his to pathological studies in experimentally-induced open wounds in Swiss albino rats. Quercetin, an active principle of the formulation, was estimated qualitatively and quantitatively through HPLC studies. Topical application of NO and EO formulations promoted faster reepithelialization, wound contraction and maximized tensile strength, increased SOD, catalase activities and GSH, hydroxyproline levels with lower myeloperoxidase and lipid peroxidation in comparison with control. Histopathological studies revealed lesser inflammatory cell proliferation, degeneration, with marked fibroblast proliferation and collagen maturation than the control group. Results indicate that both NO and EO formulations showed benefits in the management of wounds when compared to the standard povidone...
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Posted by admin on Dec 31, 2021 in |
Discovery of the drug molecule which has therapeutic values is the backbone of drug development. Pharmaceuticals have an important role in the prevention and treatment of diseases in humans and animals. However, gradual change in the process of drug synthesis from drug development to bulk production is a common complication in the drug development process. This change may result in the formation of impurities. Moreover, impurities can also be formed during transport and storage. The presence of more than the prescribed limit of impurities in the drugs may influence the purpose of the pharmaceuticals. Therefore, the evaluation of pharmaceutical drugs for the identification and quantification of impurities at various stages is essential. Several chemical and instrumental methods are used to assess the impurities. For this purpose, analytical instrumentations and methods play a crucial role. The current review highlights the development of impurities at various stages of drug development and pharmaceutical manufacturing. Moreover, this review put light on the recent advancement in the analysis of...
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