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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

IJPSR is indexed with Embase

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Posted by on Dec 31, 2020 in |

GC-MS ANALYSIS OF OIL FROM LAVANDULA LATIFOLIA L. AND ITS REPELLENT ACTIVITY AGAINST MOSQUITO

Mosquitoes are one of the important vectors of various diseases. Repellent activity significantly reduces contact with disease-transmitting mosquitoes. Essential oils have repellent activity that is being potentially developed as an alternative to commercial chemical pesticides. In this study, Lavandula angustifolia was used to evaluate its repellent activity against Ae. Aegypti. The repellent activity of L. angustifolia oil was tested with the 100, 200, 300, 400, and 500 ppm concentrations against the adult mosquitoes of Ae. Aegypti. L. angustifolia showed 100% protection up to 150 minutes against the bite of Ae. aegypti. After that, the repellency was found reduced by the increased exposure periods against Ae. Aegypti. The presence of phytochemicals in oils could be responsible for different mosquitocidal agents. Lavender oil was subjected to GC-MS analysis. It showed the presence of  37 compounds, including, 1R-à-Pinene, Bicyclo[2.2.1]heptane, 2,2-dimethyl-5methylene-, Tricyclo[2.2.1.0 (2,6)]heptane, 1,7,7-trimethyl-, Ocimene, Camphene, á-Pinene, Cyclohexene, 4-methylene-1-(1-methylethyl)-, Eucalyptol, 1,4-Cyclohexadiene, 1-methyl-4-(1-methylethyl)-, Bicyclo [2.2.1]heptan-2-one, 1,3,3-trimethyl-, 3-Oxatricyclo[4.1.1.0(2,4)] octane, 2,7,7trimethyl-, Acetaldehyde, (3,3-dimethylcyclohexylidene)-, (E)-, Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1S)-, Isoborneol, Borneol, Cyclohexanol, 1-methyl-4-(1-methylethylidene)-, Tetra-cyclo[6.3.2.0(2,5).0(1,8)]tridecan-9-ol, 4,4-dimethyl-, 1,6,10,14-Hexadecatetraen-3-ol, 3,7,11,15-tetramethyl-, (E,E)-...

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Posted by on Dec 31, 2020 in |

ANTI-CANCER POTENTIAL OF MORUSINDICA HYBRID VARIETIES IN HT-29 CANCER CELL LINES: AN EXPLORATORY STUDY

Complementary alternative medicine focuses on discovering the potential of plants in prevention and management of chronic diseases. Although Morus species has been screened for various biological activities, studies reporting the pharmacological effects of Morus indica (MI) hybrid varieties viz., V1 and S36 is scarce. This study focused on screening the phytochemical composition of Morus indica V1 (MV1) and Morus indica S36 (MS36) and evaluate its antioxidant and anti-cancer potential. The qualitative analyses revealed the presence of all major phytochemicals except alkaloids. The results of the quantitative analyses showed a better phytochemical profile in MV1 than MS36 and the values differed significantly (p<0.05). The antioxidant activity was higher in methanol extracts of both the MI varieties followed by ethanol and aqueous extracts since the extractability of phytochemicals are higher in organic solvents. MV1 had a better phytochemical profile compared to MS36 and therefore was selected for screening the in-vitro anti-cancer properties. Among the methanol and aqueous extract of MV1, aqueous extract had the lowest IC50 value viz., 55 µg/mL. The...

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Posted by on Dec 31, 2020 in |

COMPARATIVE INVESTIGATION OF TOXICOLOGICAL CHARACTERISTIC AND SPECIFIC BIOLOGICAL ACTIVITY OF THE MEDIUM-CHAIN ALIPHATIC MONO- AND DIPEROXYCARBOXYLIC ACIDS

The comparative toxicological characteristic in-vitro and antimicrobial activity to perform stability tests of several linear medium-chain aliphatic monoperoxyacids (perC8–C12) and aliphatic diperoxyacid (diperC9) were studied. Substances of peroxide acids: perС8, perС10, perС12, diperoxyazelaic acid (diperC9) are in 5.6; 22.8; 64 and 1.6 times less toxic than reference substance – peracetic acid (perC2). New knowledge concerning а comparative antimicrobial activity of studied medium-chain aliphatic peracids and their thermal sensitivity was obtained. These fundamental stability studies resulted in the emergence of safe antimicrobic agents. Nonanebis(peroxoic acid) and Peroxyoctanoic acid were proposed as an agent in the chemical disinfection prosses for the first time. Medium-chain aliphatic peracids were demonstrated to be very robust. Sufficiently high bactericidal activity was achieved after relatively short exposition times (from 10 min to 2 h for spores of B. anthracoid), at near-ambient temperature (20 °C). In this work, it has been demonstrated how stability studies can underpin rational design of antimicrobic agents that in turn lead to a both safer and economically viable chemical disinfection and sterilization...

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Posted by on Dec 31, 2020 in |

EFFECT OF CHROMIUM ON MORPHOLOGICAL AND BIOCHEMICAL RESPONSES ON AQUATIC MACROPHYTE PISTIA STRATIOTES L. (WATER LETTUCE)

The current work reports an ecofriendly approach to study morphological and biochemical responses of Pistia stratiotes L. (Water lettuce) were investigated. The assessment of morphological, biochemical parameters, and accumulation of chromium in free-floating macrophyte exposed at its various concentrations viz. 0.25, 0.50, 1.25, and 2.5 ppm of chromium at the regular intervals of 4, 8, and 12 days, respectively. Pistia showed morphological toxicity like withering of roots, chlorosis, and necrosis at higher concentrations (2.5 ppm) of chromium. However, the plant showed normal growth at a lower concentration of 0.25 and 0.50 ppm. The evaluation of biochemical parameters of test plants showed Total Chlorophyll, Carbohydrate, and Protein content was increased at lower concentrations (0.25 ppm) and decreased at higher concentrations (2.5 ppm) of chromium. The toxicity of chromium was found to be directly proportional to its concentration and duration of exposure. It is evident from the results that the accumulation of chromium can produce adverse effects on the morphology of test plant species at a higher concentration of chromium. This...

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Posted by on Dec 31, 2020 in |

DETECTION OF HUMAN NOROVIRUS IN ACUTE GASTROENTERITIS CASES FROM NORTH INDIAN PEDIATRIC POPULATION

Introduction: Human Norovirus (HuNoV) is the major cause of acute gastroenteritis in pediatric populations, accounting for approximately 18% of cases worldwide. The aim of this study was to determine the prevalence rate and characterization of genogroup in the pediatric population with gastrointestinal disease. Materials and Methods: A total of 205 fecal specimens were taken from children below 15 years of age with acute gastroenteritis disease. Samples were collected from the pediatric department of Sanjay Gandhi Post Graduate Institute of Medical Sciences, Luck now. RNA was extracted from fecal specimens and screened for Norovirus GI and GII genogroups using real-time PCR. Results: The overall rate of Norovirus infections was 23 (11.2%). Among patients positive for Norovirus, 17(74.0%) were identified as GII genogroup, and 6 (26.0%) were identified as GI genogroup. Conclusion: The majority of Norovirus associated viral gastroenteritis cases among children were attributed to GII genogroup. Younger patients were at more risk of acute gastroenteritis. As the viral transmission was evident by the oral-fecal route, the high positivity of clinical...

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