Posted by admin on Mar 1, 2016 in |
The northeast region of India, considered as ‘hot spot’ of biodiversity, having unique ecological environment with hot and high-humidity conditions, has given rise to the world’s hottest chilli, ‘Bhut jolokia or Bih jolokia’, which is at least two times hotter than Red Savina Habanero in terms of Scoville heat units (SHU). The Assamese word “bhut” refers to the typical large pod size of the plant, while the term “bih” means “poison” indicating the high hotness in the fruits of the plant. It is extensively grown in North Eastern region of India, predominantly in the states of Assam, Nagaland, Manipur and Mizoram since ancient time. The main pungency principle of Bhut jolokia (Capsicum chinense Jacq.) is capsaicin (8-methyl-N-vanillyl-6-nonenamide) and its analogs collectively known as capsaicinoids synthesized in the epidermal cells of placenta of the fruit, and possesses anti-inflammatory and antioxidant activities. This review gives an update mainly on the pharmacological activities of Bhut jolokia (Capsicum Chinense Jaqc.), benefits and toxicity of...
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Posted by admin on Mar 14, 2015 in |
Acute convulsive disorders are the most frequent neurological disorders in children which require emergency drug treatment. Immediate management of a convulsive episode is must as, delay can lead to status epilepticus, which is a significant cause of neurological morbidity and mortality among children. Benzodiazepines especially diazepam is often used as first line and routinely administered intravenously, but this is not a practical route in many peripheral health care facilities. Midazolam by buccal route is another upcoming mode of treatment in view of difficulties associated with securing an intravenous line in convulsing children with motor activity especially at peripheries, homes or even at schools. Being a developing country, malnourished group forms a significant number in our clinical practice so it was worthwhile to examine the issue of buccal midazolam’s safety and efficacy in this subset of malnourished children. It was a prospective double blind randomized control trial. Total 80 children who fulfilled the inclusion criteria were randomly allocated by a computer generated table. One group received buccal midazolam and the...
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Posted by admin on Feb 28, 2015 in |
In-vitro antibacterial and antifungal activity of Tridax procumbens plant parts (leaf and stem) were investigated by agar well diffusion method. The petroleum ether, methanol and aqueous extracts of the plant parts were tested against two bacterial strains i.e., Bacillus subtilis and Escherichia coli and two fungal strains i.e., Trichoderma reesei and Fusarium oxysporium. The results of antibacterial activity showed that methanol extract was effective and aqueous extract was devoid of any significant activity. Methanol extract of Tridax procumbens showed maximum antifungal activity. The results lend credence to the folkloric use of this plant in treating microbial infection and showed that Tridax procumbens leaves and stem could be exploited for new potent antimicrobial...
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Posted by admin on Feb 26, 2015 in |
Population control is a significant issue worldwide especially in developing countries like India. Population breakout has responsible for various deleterious effects on life surviving resources on the earth. Therefore fertility regulation is necessary for the conservation of life supporting resources as well as good reproductive life of both males and females. Various chemical methods of contraception are available today but these methods possess several side effects. Herbal medicinal plants have been used as safe alternatives of the chemical methods. Evaluation of the herbal medicinal plants has been in progress for several decades to identify effective and safe substances for fertility regulation. Several medicinal plant extract were investigated for their antifertility activity both in male and female animal models. This review covered scientific proven information on various medicinal plants used for antifertility activity in both males and females. This review provides information on botanical name along with their common name, antifertility activity, part used and their phytochemicals present in...
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Posted by admin on Feb 26, 2015 in |
Synthesis of heterocylic compound has always drawn the attention of chemist over the years mainly because of their important biological properties. Particularly, the role of β–lactam which are endowed with unique structure and potent biological activity. The β-lactam heterocycles are considered as an important contribution of science to humanity since they have been constituents of living organisms, natural products, drugs and many more substances useful to mankind and society in all walks of life. Their synthesis and evaluation has always drawn the attention of biologists over the years. β-lactam, a four member heterocyclic compound involved in research aimed to evaluate new products that possess interesting biological activities. Natural and synthetic β-lactam derivatives occupy a central place among medicinally important compounds due to their diverse and interesting antibiotic activities and are still the most prescribed antibiotics used in medicine. The present review article focuses on the pharmacological profile of β-lactam with their potential activities. The ring system exhibits a wide range of activities like antimicrobial, antitubercular, anticancer, antidiabetic, tryptase and...
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