Posted by admin on Feb 26, 2015 in |
Lovastatin is a naturally occurring drug of statin family used for lowering cholesterol. It is found that it can be useful for treatment or management of multiple diseases and has immense medicinal significance. On one side, this drug is used to induce apoptosis in various cancer cells, while other reports indicate that it also promotes cell survival to alleviate certain disease conditions. Antiviral role of lovastatin has also been reported. So, lovastatin, if recommended for any therapy, first requires thorough study as well as experimentations both in-vitro and in-vivo. Current review is systematic, based on search from PubMed by entering key words “Lovastatin cancer, Lovastatin apoptosis and Lovastatin survival” with filter for seven years (2008-2014) data only. It is concluded from the study that Lovastatin has multidirectional role and may be helpful in cancer cells apoptosis as well as survival of certain types of cells. It may be used as anti-viral agent...
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Posted by admin on Feb 26, 2015 in |
A budding interest in Nanopharmaceuticals had generated a number of advancements throughout recent years with a focus on engineering novel applications. Nanophytomedicines are prepared from active phytoconstituents or standardized extracts. The world market for nanomedicine is estimated to reach $130.9 billion by the fiscal year 2016. Liposome nanoparticle (NP) with entrapped doxorubicin was reported by researchers to be 300 times more effective because of better pharmacokinetic ability in treatment of Kaposi sarcoma. Nanotized herbal drug containing active principles of seawort, cassia twig and liquorice root was found to be effective in pulmonary, liver, bone and skin cancer. Nanotechnology also offers the ability to detect diseases at much earlier stages, such as finding hidden or overt metastatic colonies often seen in patients diagnosed with breast, lung, colon, prostate, and ovarian cancer. However, the safety and long-term effects of nanoformulations must not be overlooked. This review will provide a brief discussion of the major nanopharmaceutical formulations as well as the impact of nanotechnology on herbal drugs in...
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Posted by admin on Feb 26, 2015 in |
Over the past few decades the nasal route has gained widespread interest as a promising and an alternative route to oral and parenteral drug delivery. The nasal mucosa being highly vascularized and permeable provides a rapid onset of therapeutic action. It is a convenient, compliant and needleless mode of drug delivery suitable for the treatment of both acute and chronic diseases. In addition, nasal drug delivery circumvents the issues of poor and slow absorption, first pass hepatic metabolism, blood brain barrier. Intranasal administration can be used to deliver small polar molecules, hormones, vaccines, proteins and peptides. Despite the several potential advantages the nasal route has certain limitations. The present review outlines the various merits and demerits of intranasal administration, the relevant anatomy and physiology of the nasal cavity. The present article gives a detailed description of the factors affecting drug absorption and the different strategies that can be used to improve the drug...
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Posted by admin on Feb 26, 2015 in |
Apoptosis, a well choreographed gene-directed cellular destruction, plays an important role in a variety of biological events, including morphogenesis, homeostatic maintenance of various tissues and removal of harmful cells while dysregulated apoptosis has been implicated in a variety of disease such as cancer, systemic and organ specific autoimmune disease and neurodegenerative disorders. Apoptosis is initiated by extracellular or intracellular signals in which complex machinery is activated to start a cascade of events ultimately leading to the degradation of nuclear DNA and dismantling of the cell. Cellular disruption results from the activation of a family of cysteine proteases known as caspases. Caspases are synthesized as inactive proenzymes, which upon activation cleave various substrates in the cytoplasm or nucleus leading to changes in morphological and cell death. The goal of this review is to provide a general overview of basic knowledge on the process of apoptosis including morphology, characterization, assays, anti apoptotic genes, mechanisms and relevance to...
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Posted by admin on Feb 26, 2015 in |
A simple, rapid, sensitive, precise, accurate and economic isocratic stability indicating RP-HPLC chromatographic method was developed and validated for the simultaneous estimation of Glimepiride and Ezetimibe in bulk and tablet dosage form. The method was developed through a Hypersil ODS C18 (150mm x 4.6 mm, 5m) column, mobile phase comprised of phosphate in water as buffer PH adjusted to 4.8 with tri ethylamine, acetonitrile in proportion ratio 30:70v/v and at the flow rate of 1 ml/min. GLM and EZE were eluted at acceptable retention times of 3.328 and 2.322 minutes respectively with good resolution by monitoring UV detection at 237 nm. Calibration plots were linear in the concentration range of 2.5-15 µg/ml for GLM and 25-150 μg/ml for EZE with correlation coefficient(r2) 0.999 and 0.999 respectively. The total run time is 6 min. The studies were carried out by conducting deliberate degradation of the sample with exposure to stress conditions like acidic (1M HCl), alkaline (1M NaOH), 1050C heat, oxidizing agents (H2O2) and water. This method was validated and...
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