Posted by admin on Mar 1, 2016 in |
Transdermal drug delivery systems (TDDS) offers a route that by-passes the gut and hence they are more convenient. They are also non-invasive and safer than the other alternatives. The transdermal or the adhesive patches are used to deliver a specific quantity of drug in a controlled release manner through skin for over a long period of time. There are many types of patches like the matrix, membrane, reservoir, micro reservoir etc. These patches have been in use to deliver many classes of drugs like analgesics, anti-pyretics, anti-diuretics, anti-asthmatics, etc. There are many anti-asthmatic products that are available in the form of transdermal patches internationally like the tulobuterol, salbutamol, ketotifen, etc., but the question is about their usage and availability. The primary aim of this review is to understand the availability of evidences for and against the use of TDDS for asthma. Most studies, both in vivo and in vitro, and both as add-on and as a monotherapy have yielded positive...
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Posted by admin on Mar 1, 2016 in |
Tablets are widely used and most preferred dosage form because of its ease of manufacture and administration, lower cost, good aesthetic appearance. Now a days new trends are going to develop in formulation of conventional tablet in to modified tablet dosage forms like floating, sustained release matrix, coated tablets, controlled release, fast release etc. This review provides the detail information of compression coated tablets including its classes, polymers commonly used in different layers, methods of preparation of subsequent layers of tablets and exist formulations of various categories of...
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Posted by admin on Mar 1, 2016 in |
The approach to the process validation of pharmaceutical manufacturing processes has been changed and the minimal approach (traditional) is no longer recommended 1-6. As the regulatory requirements are being changed, considering the patient safety and drug efficacy, an enhanced and science based approach is recommended for the process validation of medicinal product manufacturing processes. The major regulatory bodies like USFDA and EU has revised their approaches towards process validation and recommending industry to proceed with enhanced approach towards process validation. To reach the regulatory requirements regarding the process validation, tools like Quality risk management (ICH Q9), Pharmaceutical quality systems (ICH Q10) shall be useful. In-addition Quality by design is a new approach, which is a combination of several Quality system elements like Pharmaceutical development, Quality risk management, Pharmaceutical quality system which will leads to a life cycle approach to the process validation 7. This article will enable the readers to understand the science and risk approaches to the process validation, and usage of Quality by design concepts while developing...
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Posted by admin on Mar 1, 2016 in |
Adverse Drug Reactions associated with drugs are common and impose a serious health related problem, which can limit the treatment options, compliance and even leads to discontinuation of therapy. Hypertension is a chronic disease condition which is considered to be one of the major cardiovascular risk factor. For the treatment of hypertension a wide range of anti-hypertensive agents are available as single or combination therapy to achieve a target blood pressure in individual patient, whereas the combination therapy increases the risk of developing Adverse Drug Reaction. Hypertensive patients often have concomitant disease condition such as hyperlipidemia, impaired glucose metabolism and renal impairment, leading to an increased rate of Cardio Vascular morbidity and mortality. Therefore, a comprehensive management of both hypertension as well as concomitant Cardio Vascular Disease risk factors is critical when treating hypertensive patients. Beta-blockers provoked psoriasis, calcium channel blockers induced gingival hyperplasia, peripheral oedema, Angiotensin Converting Enzyme inhibitors produced ankle oedema and thiazide diuretics produced hyponatremia, hyperglycemia are some of the rare and serious Adverse Drug Reaction...
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Posted by admin on Mar 1, 2016 in |
Plants have been one of the important sources of medicines since the beginning of human civilization. There is a growing demand for plant based medicines, health products, pharmaceuticals, food supplements, cosmetics etc. A review of chemical constituents present in various parts of Tinospora cordifolia and their pharmacological actions is given in the present article. Tinospora cordifolia, is a commonly used shrub in Ayurvedic medicine. Although the review articles on this plant are already published, this review article is presented to comply all the updated information on its phytochemical and pharmacological activities, which were performed by widely different methods. The notable medicinal properties are anti-diabetic, anti-spasmodic, anti-malarial, anti-inflammatory, anti-arthritic, anti-oxidant, anti-allergic, anti-stress, anti-leprotic, hepatoprotective, immunmodulatory & anti-neoplastic...
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