Posted by admin on Feb 28, 2021 in |
The solubility and dissolution properties of any drug are vital determinants of its oral bioavailability. The aim of this study was to increase the dissolution rate of poorly soluble drug Atorvastatin calcium by delivering the drug as a liquisolid compact, prepared by using PEG as a solvent, Avicel PH 102 as carrier, silica, and lactose are used as coating materials. Sodium starch glycolate was used as super disintegrants and evaluated for their flow properties, drug excipient compatibility by FT-IR, DSC, respectively. Dissolution studies for liquisolid formulation and directly compressed tablet were carried out at a buffer pH 6.8 and found an increase in drug release of 101.71% and 80.09% at 45 min,...
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Posted by admin on Feb 28, 2021 in |
Coronaviruses wrapped with the layers of positive-sense RNA viruses specified by the club-like projections from their surface responsible for a variety of diseases in the animal kingdom. After the two historical episodes of coronaviruses i.e., severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, this time world strike with its highly pathogenic form which is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease (COVID-19) is a viral cascade event that starts from Wuhan in December 2019 and becomes a public health emergency of global interest as declared by the World Health Organization. Primarily, bats became an identifiable source of SARS-CoV-2 and their transmission to humans has occured through an unknown intermediate source. Present situation depicts that more than 200+ countries are suffering from the deadly attack of SARS-CoV-2. This virus is dangerous for every age group because of its asymptomatic carrier state that results in acute respiratory diseases. Escalation of this virus occurs very easily through human-to-human transmission via droplets...
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Posted by admin on Feb 28, 2021 in |
Background: Epilepsy is a chronic disorder that causes unprovoked, recurrent seizures like a sudden rush of electrical activity in the brain. Neuronal hyperexcitability in epilepsy is due to an imbalance between glutamate-mediated excitation and GABA-mediated inhibition. Aim: This prompted us to design newer CSF1R inhibitors as efficient therapeutic drugs for the treatment of epilepsy. Materials and Methods: Based on the common pharmacophoric features for the inhibition of CSF1R inhibitors, a series of leads were designed using computational methods. A virtual library consisting of newly designed 60 molecules as CSF¬1R inhibitors were constructed .Based on these facts, a virtual library has been generated with 60 newly designed ligands containing imidazole, benzo pyrrole, quinoline, oaxzole, quinoxaline, benzimidazole, heterocyclic nucleus as CSF1R inhibitors (60). The binding mechanism of newly designed ligands with target enzymes CSF1R inhibitors was studied using Auto dock tools 1.5.6. Conclusion: The designed compounds were subjected and filtered by applying ADMET properties. In comparison with docking scores of standard antiepileptic drugs vigabatrin (GABA-2.14, CSF1R-1, 31) and sodium valproate (GABA-3.19,...
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Posted by admin on Feb 28, 2021 in |
The motivation behind composing this review on floating drug delivery systems (FDDS) was to incorporate the ongoing research article with a unique spotlight on the key system of floatation to accomplish gastric maintenance. The ongoing advancements of FDDS, including the physiological and formulation factors influencing gastric maintenance, ways to deal with configuration single-unit, and numerous unit of floating drug delivery systems, and their grouping and formulations perspectives are canvassed in detail. This review has a special focus on the principal mechanism of floatation to achieve gastric retention. Conventional oral dosage forms have short residence times & unpredictable gastric emptying time. The idea of gastric retention comes from the need to localize drugs at a specific region of the gastrointestinal tract (GIT), such as the stomach in the body. Many drugs get absorbed only in the upper intestinal tract, designing such molecules as once-daily formulations are exclusive for these molecules. Thus, gastro retention could help to provide greater availability of new products and consequently improved therapeutic activity and substantial benefits...
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Posted by admin on Feb 28, 2021 in |
Tuberculosis holds one of the top places on the list of the main cause of death in India. At times, the patients fail to respond to treatment with anti-Tb drugs, drug resistance being one of the reasons. The increasing incidence of MDR and XDR-TB highlights the urgent need to search for newer anti-Tb drugs. For last many years, plants have beneficial activity in a different types of diseases producing in human beings. As per WHO calculation about 80% of the world’s inhabitants problem should treat by medicinal herbal drugs for their primary health care. So, the present aim to carry out the evaluation of the anti-mycobacterial activity of selected eleven medicinal plants. Three different extracts were prepared and evaluated for their antimycobacterial activity against Mycobacterium smegmatis using MTT and Microplate Resazurin assay. Isoniazid was used as a standard drug. The percentage for anti-mycobacterial smegmatis activity among tested eleven medicinal plants, an aqueous extract of Cocculus hirsutus and Leptedinia reticulata shows potent antimycobacterial activity. Thus, its result supports the uses...
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