Posted by admin on Feb 28, 2019 in |
The present work deals with a novel synthesis of AgF/Ag2WO4 nanocomposite by co-precipitation method. The morphology and size of the synthesized AgF/Ag2WO4 nanocomposite were confirmed by Ultraviolet-Visible (UV-Vis) spectroscopy, Fourier Transform-Infrared (FT-IR) spectroscopy, Transition Electron Microscopy (TEM) and X-Ray Diffraction (XRD) analyses. The performance of the nanocomposite was successfully evaluated for Cr6+ detection in a gelatin capsule, which indicated that this convenient and sensitive material offered great promise for onsite environmental monitoring of Cr6+. Control experiments with the addition of over 10 other metal ions (Na+, K+, Mg2+, Fe2+, Hg2+, Ca2+, Cu2+, Ni2+, Mn2+, Zn2+) did not result in a distinct change in the colour or in the spectrum of the suspension which indicated that these ions did not interfere in the colorimetric determination of Cr6+ in gelatin capsule. The detection concentration of Cr (VI) ranged from 0.5 mg to 1.0 mg, and the detection limit was 2...
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Posted by admin on Feb 28, 2019 in |
Alzheimer disease (AD) is the most common cause of dementia which affects more than 44 million individuals worldwide. It has been noticed that there is only symptomatic treatments are available to treat AD, but no cure exists. It is a neurodegenerative disease characterized by Alois Alzheimer’s in 1906, and neuro-degenerative diseases are one of the major concerns facing by the modern health care system. It is a multifarious complex disease which pathology not clearly understood but it is generally characterized by neuronal damage, memory dysfunction, etc. main pathological hallmark factor for Alzheimer disease is deposition of amyloid-β (Aβ) plaques around the neurons, neurofibrillary tangles, and a decrease in acetylcholine concentration and some other neurotransmitter dysregulation. Different types of risk factors like oxidative stress, obesity, diabetes, hypertension, air pollution, smoking, hyper cholesterolemia etc. have a very significant role in the development of AD and in the development of its preventive measures. Physical exercise and nutritional factors have been shown as protective measures for it and help in its prevention. For...
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Posted by admin on Feb 28, 2019 in |
In continuation of our efforts in the development of novel drugs, in the present article we have described synthesis of a series of novel azetidinones derivatives (4a-i) containing 5-(benzofuran-2-yl) and 1-phenyl-1H-pyrazole-3-carboxamide moiety, with excellent yields and without formation of undesirable side products from cyclo condensation reaction of N’- (benzylidene) -5- (benzofuran- 2- yl) -1 -phenyl -1H -pyrazole- 3-carbohydrazide derivatives (3a-i) with chloro acetyl chloride in the presence of triethylamine in DMF. Carbohydrazones of aryl aldehydes (3a-i) used as the starting compound was obtained by one-pot condensation of 5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide (1) with various substituted aromatic aldehydes (2a-i) and a catalytic amount of acetic acid in ethanol. The structures of newly synthesized compounds have been established through elemental analysis and spectral studies like IR, 1H NMR, 13C-NMR and Mass spectra. All the synthesized compounds were screened for their in-vitro antibacterial activity against different strains of microbes such as S. aureus, E. coli, P. vulgaris and S. typhi at different concentration. The result of the bioactivity confirmed that most of the newly synthesized...
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Posted by admin on Feb 28, 2019 in |
Standardization can create trust and confidence in the products and increase market relevance. It is an essential requirement for the open exchange of information; without it, the network will simply not work. The practitioner, as well as the consumer, now seeks assurance from the manufacturer about the quality, safety, and efficacy of a readymade Herbal supplement or Ayurvedic formulations. An average person’s diet, lifestyle and other social habits, all who play important roles in disease and treatment, are completely different today. Hence, the earlier recommendations for herbs for specific disease states may not hold today unless validated in today’s times. Phenotypic changes in plant species. Hence the original pharmacological claims of these formulations need to be revalidated. Pharmaceutical research is aimed at meeting the medical needs of the population for whom appropriate therapeutic remedies are not available or at those that are available are unsafe for prophylactic use for various disorders. While meeting medical needs, research also has to ensure that the market needs for such exist. Vranropantaila is...
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Posted by admin on Feb 28, 2019 in |
Nanotechnology is an advancing technology expected to bring revolutionary changes in the field of life sciences including drug delivery. The advance in nanotechnology helps in the preparation of new pharmaceutical formulations with high benefits. One of its approaches is to stabilize the niosomal drug delivery system without affecting its properties have resulted in the development of proniosomes, a drug carrier. Proniosomes are solid colloidal particles which may be hydrated immediately before use to yield aqueous noisome dispersions similar to those produced by conventional methods. These proniosomes minimize the problems related to conventional niosomes such as aggregation, fusion, leaking and provide additional convenience in transportation, distribution, storage and dosing with enhanced stability. Ofloxacin loaded maltodextrin based proniosomes were prepared by a slurry method with a different surfactant to cholesterol ratio. The formulated proniosomes possessed good flow property and smooth surface confirmed by SEM study. FTIR spectra’s confirmed no interactions between drug and carrier. The niosomal dispersions were formulated and further evaluated for particle size, polydispersity index (PDI), zeta potential, TEM,...
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