Posted by admin on Apr 1, 2014 in |
Interferons were the first cytokines to be used therapeutically as naturally derived and as recombinant forms in humans. Their broad biological activity has resulted in clinical benefits in diseases ranging from infectious (such as viral hepatitis), autoimmune (in particular multiple sclerosis) to neoplastic (lymphomas and carcinomas). Since Interferons enhance the immune system in many ways, they are used for many diseases that involve the immune system. For example; Interferon alfa-2a (Roferon-A) is FDA-approved to treat hairy cell leukemia, AIDS-related Kaposi’s sarcoma, and chronic myelogenous leukemia. Interferon alfa-2b is approved for the treatment of hairy cell leukemia, malignant melanoma, condylomata acuminata, AIDS-related Kaposi’s sarcoma chronic hepatitis C, and chronic hepatitis B. Ribavirin combined with interferon alfa-2b, interferon alfacon-1 (Infergen), pegylated interferon alfa-2b, or pegylated interferon alpha-2a, all are approved for the treatment of chronic hepatitis C. Interferon beta-1b (Betaseron) and interferon beta-1a (Avonex) are approved for the treatment of multiple sclerosis. Interferon alfa-n3 (Alferon-N) is approved for the treatment of genital and perianal warts caused by human papillomavirus (HPV). Interferon...
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Posted by admin on Apr 1, 2014 in |
An imbalance between oxidants and antioxidants generates the oxidative stress. Oxidative stress is the major cause of many diseases like cardiovascular, respiratory disease, renal diseases, neurological diseases, cancer, and aging. Cardiovascular complications are the leading cause of mortality in patients so the purpose of this review is to evaluate the effectiveness of N-acetylcysteine (NAC) in the treatment of cardiovascular diseases. N-acetylcysteine is an antioxidant which confers its protective effect by minimizing oxidative stress and oxidative stress associated problems. A search using the Pub Med database was conducted using the keywords N-acetylcysteine and mice heart. All research articles related to the use of N-acetylcysteine in protection of mice heart were discussed. A total of 93 articles were identified during this broad search while 30 articles were included for review recommending the N-acetylcysteine for protection of heart. This review proved that N-acetylcysteine has a positive role in management of multiple heart...
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Posted by admin on Apr 1, 2014 in |
Thuja occidentalis called the tree of life is an endemic plant in eastern North America and cultivated in northern Europe and in Brazil as ornamental tree. According to the popular use of this plant has been used in herbal and homeopathic preparations for acute and chronic infections of the upper respiratory tract, warts, as adjunctive antibiotic, immunostimulant. However, these and other data are old or unavailable, and in view of the therapeutic potential of the species, it was necessary to upgrade the recently published studies and not included in previous reviews about the botanical, pharmacological, toxicological and technological aspects. In this review article, it was noted that for many years the phytochemistry studies on the species concentrated their efforts around essential oils, highlighting the monoterpene thujone, which is attributed to the pharmacological and toxicological activities. Recently, preclinical studies have identified the presence of polysaccharides, flavonoids, tannins and proteins in the ethanol fraction, which showed antioxidant, hepatoprotective, antitumor, hypolipidemic, antidiabetic and antiulcerative activity. The clinical studies proving its immunostimulant and...
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Posted by admin on Apr 1, 2014 in |
The main objective of the present study is to enhance the dissolution of clopidogrel bisulphate in intestinal fluids by formulating into mini-tablets with in-situ acidifying agent mini-tablets. The solubility data reveals, Clopidogrel bisulphate is freely soluble in pH 2.0 and the solubility decreases with increase in pH. Whereas, with weak acid, the solubility of clopidogrel is increased at pH 5.0 blank fed state simulated intestinal fluid and & pH 6.5 blank fasted state simulated intestinal fluid. Hence, tartaric acid is selected in the core tablet to enhance the dissolution of clopidogrel tablets at intestinal fluid pH 5.0 & pH 6.5. Formulation was evaluated with different levels of tartaric acid in core tablet. Formulation with 50mg/unit of tartaric acid showed the extent of dissolution of 100% in pH 5.0 blank fed state simulated intestinal fluid and 96% in pH 6.5 blank fasted state simulated intestinal fluid. To control the impact of humidity on degradation, a moisture protective layer is coated on core tablet with non-aqueous solvent, using conventional coating pan....
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Posted by admin on Apr 1, 2014 in |
Parthenium hysterophorus L., compositae, also known as congress weed, carrot weed, star weed, reaching a height of 2 m in weeks of germination, is believed to have entered India accidentally in the mid 1950’s and is now available abundantly all over the India. Leaves are traditionally used in the treatment of asthma and allergy, leavas of the plant were extracted successively using aqueous and ethanol solvents to obtain the respective extracts. In the present study, we have investigated the role of aqueous and ethanol extracts of Parthenium hysterophorus against milk-induced leukocytosis and eosinophilia in albino mice. The results of the study revealed that pretreatment with both the extracts caused significant reduction in the total leukocyte and eosinophil counts in animals in dose-dependent manner. From these results, it can be concluded that the plant Parthenium hysterophorus is having antieosinophilic...
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