Posted by admin on Apr 1, 2014 in |
Since Dr. Tsuneji Nagai of Hoshi University, Japanin the early 1980’s used the concept of bio adhesion for the delivery of insulin across the buccal mucosa in beagle dogs; several researchers tried a large number of drugs for administration through buccal mucoadhesive dosage forms. The potential of these dosage forms have been found to be tremendous because of their ability to improve the bioavailability of many such drugs by bypassing the hepatic first pass metabolism. Because of the growing number of newer molecules in the form of peptides and proteins, the research in this field has gained the centre stage for the non-invasive drug delivery as an alternative to parenteral route. The novel design of the buccal delivery system can be achieved by the help of polymers of synthetic and natural polymers. The purpose of this review article is to establish the developments and highlight the importance of mucoadhesive buccal delivery for low bio available...
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Posted by admin on Apr 1, 2014 in |
The therapeutic use of herbal medicine has gained considerable momentum in the world during the past decade. Hence, Quality control standards for various medicinal plants used in indigenous systems of medicine are becoming more necessary. Adulteration and misidentification of medicinal plants can cause serious health problems to consumers and pose legal problems for pharmaceutical firms. So, the aim of this investigation was to establish a simple and efficient protocol to determine possible drug adulteration by use of similar plants. Powder microscopy can help the correct identification and establish standardization of plant drugs. The present study has revealed an easy way to identify Alpinia calcarata and Alpinia galanga microscopically and thus it can also be employed to detect the degree of adulteration in powdered raw medicinal plant materials as well. Likewise, microscopical detection is easy, reliable and cost effective tool for detection of adulteration in medicinal plants.Alpinia calcarata Rosc. and Alpinia galanga Linn. of Zingiberaceae popularly known also as Lesser galangal and greater galangal, have a widespread occurrence in India,...
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Posted by admin on Apr 1, 2014 in |
The present work was designed to formulate floating tablet of Metoprolol Succinate with synthetic superdisintegrant as swelling agent. Various formulations of Metoprolol Succinate were prepared by direct compression method using the different concentrations of superdisintegrant ranging from 10% to 15%. The selected batches were evaluated for various parameter like weight variation, thickness, diameter, friability, floating lag time, duration of floating, water uptake, content uniformity, in-vitro drug release and in-vitro drug release kinetics. Formulations with Crosspovidone had showed better results than the Kyron T-314. The data obtained from the in-vitro dissolution studies of optimized batch F5 was fitted in different models viz. zero order, first order, Korsemeyer-Peppas model, Higuchi model and Hixon-Crowell model. Drug release mechanism was found to be First order from optimized formulation. Further for getting the type of release mechanism the data was fitted as per the Korsemeyer-Peppas equation. The exponent value n was found in between 0.45 to 0.89. It indicates that the release of Metoprolol Succinate from developed floating tablets followed non-Fickian transport...
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Posted by admin on Apr 1, 2013 in |
Camellia sinensis and Citrus sinensis are treasuries of medicinal properties. The compounds present in these plants can deliver potential therapeutic drug. Most of the drugs in clinical development fail to commercialize because of poor ADME and toxicity properties. The main aim of the study is pharmacokinetic investigation and toxicity property, the most causes of high attrition rates in drug development and it should be considered as early as possible in the drug discovery...
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Posted by admin on Apr 1, 2013 in |
Plants rich in antioxidants and phytochemicals especially phenolic groups play a protective role in health and disease conditions, like cancer, diabetes, heart disease hypertension etc. by counteracting reactive oxygen species and inhibiting the lipid oxidation. Morus indica is non-toxic natural therapeutic plant used as herbal medicine as hypoglycemic, hypotensive, and diuretic properties. In the present study proximate, phytochemical and antioxidant profile in dehydrated leaves powder of Morus indica varieties, M5, V1 and S36 were estimated. The 100% methanol, 80% methanol (methanol & water, 8: 2), dechlorophyllised, aqueous cold and hot extracts were prepared and their polyphenol content, antioxidant activity of inhibiting oxidation in oil emulsion and liver microsomes was evaluated at 300 to 500µg. There was no significant (P<0.05) difference in the moisture, fat and ash content. All the three samples were found to be good sources of major minerals viz. Iron, Calcium phosphorus and also of trace elements like manganese, zinc, copper, potassium.S36 found to be rich in phytochemicals and antioxidants. The polyphenol content was in the order...
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