Posted by admin on Mar 31, 2018 in |
Coconut shell oil was extracted from raw coconut shells, collected from Thiruvallur District. These were extracted using various solvents based on the polarity which includes ethanol, chloroform, acetone, petroleum ether and aqueous. The antibacterial activity against the growth of Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Salmonella typhi was done. The antifungal activity against the growth of organisms such as Epidermophyton floccosum, Aspergillus niger, Penicillium, Microsporum canis, Candida albicans and Aspergillus flavus were tested. The extracts were compared with standards like novobiocin, amoxillin and ketoconazole for antibacterial and antifungal activity respectively. The results indicate that zone of inhibition increased when increasing the concentration of the extracts. Among the five extracts of coconut shell oil the ethanolic extract exhibited maximum antibacterial activity against six bacterial strains. Ethanol and petroleum ether extract showed maximum inhibitory activity against Epidermophyton and Candida albicans. This study showed that coconut shell oil possesses antimicrobial...
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Posted by admin on Mar 31, 2018 in |
Introduction: Menorrhagia that means excessive uterine bleeding is one the most common reasons that women refer to gynecological centers. Despite the use of “Quince paste” in Iranian Traditional Medicine (ITM) clinics, no studies have been done in this regard. Objectives: This study was carried out to investigate the effect of “Quince paste” on uterine bleeding in patients with menorrhagia. Materials and methods: This study was a clinical trial of before-after pilot study conducted on 35 patients aged 18-50 years suffering from menorrhagia. A tea spoonful of “Quince paste” after each meal was prescribed for two months. A pictorial form was completed to determine bleeding volumes and days as well as quality of life questionnaire before and at the end of the intervention. Results: Patients age was 33.8 ± 10.8 years and BMI was 28.94 ± 14.07. Bleeding score decreased significantly after two months of intervention (from 264.2 ± 198.9 to 125.8±155.9), (p<0.001). Quality of life score decreased significantly from 30.28 ± 5.73 to 22.02 ± 3 (p<0.001). Bleeding days...
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Posted by admin on Mar 31, 2018 in |
Chronotherapeutic drug delivery systems have been recognized as potentially beneficial to the chrono-therapy (time optimized) of chronic diseases that display time-dependent symptoms. In pulsincap system, therapy can be optimized by tailoring the dosing schedule based on chrono-biological pattern. The safety and efficacy of the drug is achieved by coordinating the peak plasma concentration with circadian rhythm. People with rheumatoid arthritis, usually experience peak pain in the morning. The absorption kinetics of conventional dosage forms that have night time dosing indication is inadequate in the morning, when the need is more. Ketoprofen is a potent NSAID used to treat RA. In the present study, a modified pulsincap of Ketoprofen was developed and evaluated. Hard gelatine capsule bodies were treated with formaldehyde and are filled with best formulations of solid dispersion (β-cyclodextrin) for burst release and microsponge (ethyl cellulose) for sustained release after specific lag time attained by hydrogel plug. The filled capsules were completely coated with 5% CAP to prevent variable gastric emptying. The results indicated that formulated pulsincap of...
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Posted by admin on Mar 31, 2018 in |
Probiotics are live microorganisms that confer many health benefits to the host when administered in adequate quantities. These health benefits have garnered much attention towards probiotics and have given an impetus to their use as dietary supplements for the improvement of general health and as adjuvant therapies for certain diseases. The increased demand for probiotic products in the recent times has provided the thrust for probiotic research applied to several areas of human biology. The advances in genomic technologies have further facilitated the sequencing of the genomes of such probiotic bacteria and their genomic analyses to identify the genes that endow the beneficial effects they are known to exert. This work reviews the application of genomic strategies on probiotic bacteria, while providing the details about the probiotic strains whose genome sequences are available. It also consolidates the genomic tools used for the sequencing, assembly and annotation of the probiotic genes and how it has helped in comparative genomic...
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Posted by admin on Mar 31, 2018 in |
In this article, we have reviewed several features of nanomicelles relating to their general properties, preparation and characterization techniques, and their applications in the areas of ocular drug delivery system. Nanomicelles can be rummage-sale as ‘smart drug carriers’ for targeting certain areas of the eye by making them stimuli-sensitive or by attachment of a specific ligand molecule onto their surface. In present scenario, the major challenge for the researchers is ocular drug delivery system as eye is the most sensitive organ in our body. Topical eye drop is the best suited way for delivery of drugs for the treatment of anterior segment of the eye. Delivery of the drugs to the targeted areas is restricted by the various barriers and even the amount instilled do not remain there for a long duration of time. In the past many years scientist are working on providing the masses the way for delivering drug in a novel, safe and patience compliance manner. The aided the basic delivery by providing the administration through...
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