Posted by admin on Jun 30, 2025 in |
Post-traumatic stress disorder (PTSD) affects a significant portion of the global population and can lead to chronic psychiatric complications and other secondary health issues. Among these, cardiovascular disease (CVD) stands out prominently. The relationship between PTSD and CVD is complex and bidirectional, with PTSD increasing the risk of developing CVD and worsening its prognosis. This review explores the physiological, psychological, and behavioral pathways through which PTSD influences cardiovascular health, including dysregulation of the autonomic nervous system, chronic inflammation, and endothelial dysfunction. These mechanisms highlight the profound impact of PTSD on cardiovascular risk factors such as hypertension, dyslipidemia, and metabolic syndrome. Effective management strategies necessitate integrated approaches that address both PTSD symptoms and cardiovascular risk factors, emphasizing early intervention, lifestyle modifications, and psychological therapies. Understanding and managing the PTSD-CVD link is crucial for optimizing care and improving outcomes in affected...
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Posted by admin on Jun 30, 2025 in |
The objectives of the present study were to formulate facial powder cleansers using colored clays, green clay or red clay, as main ingredients and to investigate the foaming and cleansing properties of the powder cleansers. For foaming and cleansing purposes, natural foaming tea and synthetic sodium cocoyl isethionate (SCI), were employed. Eight formulations were prepared by varying types and amounts of colored clays (58.5% and 68.5% w/w) as well as surfactants (10% and 20% w/w). The formulations F1 to F4 contained red clay whereas F5 to F8 contained green clay. Then, appearances, pH values, foaming and cleansing abilities of the formulations were investigated. The stability of the cleansers was also evaluated by keeping the preparations at ambient temperature and 45 °C for 60 days. Small differences in color shades of facial cleansers were detected using a spectrophotometer and CIELAB color system. The prepared cleansers had weak acidic pH (pH 5.7 to pH 6.5). The formulations with synthetic SCI had superior foaming property to those with foaming tea (p <...
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Posted by admin on Jun 30, 2025 in |
Background: Tuberculosis is a great menace to mankind since ancient times. The genus mycobacterium was known to originate 150 million years ago. Despite the discovery of many newer methods in the diagnosis of tuberculosis, a robust point of care test is required for effective management of Paediatric tuberculosis. Methodology: We conducted this study in paediatrics department of N.M.C.H for 1 year. After obtaining written informed consent, we enrolled cases in our study. All cases were subjected for focussed history from Guardians. Gastric Aspirate, Sputum, Induced Sputum, Ascitic fluid, CSF were collected is a wide mouthed container for sputum microscopy & in Falcons tube for CBNAAT. The microscopic examination of the samples were done by LED microscope using Z-N staining Technique. Results: Out of 51 samples analysed by microscopy and CBNAAT, CBNAAT has higher positivity rate (17.6%) than microscopy technique (5.8%). Result analysed using chi square test, considering CBNAAT as gold standard. The resulting value (p=0.027) interprets that the p value is less than 0.05. It is statistically significant. Conclusion:...
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Posted by admin on Jun 30, 2025 in |
Background: Pharmacogenomics, a cornerstone of precision medicine, studies genetic variations that influence individual drug responses. By leveraging genomic technologies, it enables personalized medicine, optimizing drug efficacy and reducing adverse effects. Objective: This review provides a comprehensive overview of pharmacogenomics, examining its scientific principles, technological advancements, clinical applications, and associated challenges, alongside emerging trends like AI and big data. Methods: A systematic literature review of recent peer-reviewed studies, clinical research, and regulatory reports was conducted using databases such as PubMed, ScienceDirect, and Google Scholar. Key Findings: Pharmacogenomics focuses on genetic variability in drug metabolism (e.g., CYP450 enzymes), driving personalized therapies. Clinical successes in oncology, cardiology, psychiatry, and infectious diseases underscore its benefits. Advances in next-generation sequencing, GWAS, and bioinformatics tools like PharmGKB have propelled research and clinical integration. However, challenges include rare gene-drug interactions, high costs, healthcare disparities, and ethical concerns related to genetic data. Future directions emphasize gene-editing technologies, diverse population studies, and AI-driven discoveries. Conclusion: Pharmacogenomics offers transformative potential for healthcare through individualized therapies. However, its widespread clinical...
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Posted by admin on Jun 30, 2025 in |
This article explores the transformation of pharmaceutical research and development by the combination of digital twins and generative artificial intelligence (AI), especially in drug discovery. It highlights various cases that illustrate the increasing use of digital twins of biological systems alongside generative AI algorithms to speed up the identification of new drugs. This approach involves simulating vast chemical landscapes and predicting molecular properties, which facilitates the discovery of novel compounds that may have previously been overlooked. By leveraging computational models and machine learning, researchers can design targeted compounds, refine potential therapy candidates, and simulate their interactions within complex biological environments. This method accelerates the identification of promising drug candidates while predicting their efficacy and safety more efficiently, without extensive in-vivo testing. Furthermore, digital twins allow for a more personalized approach to drug development, enhancing the chances of success for specific patient groups. This cutting-edge methodology presents significant opportunities to streamline drug development processes, lower costs, and ultimately improve patient outcomes by delivering more effective treatments. However, the integration of...
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