Posted by admin on Jun 30, 2022 in |
ACAT enzyme is found in human body and it maintains cholesterol homeostasis in the cell. This leads to deposition of cholesterol in our body as cholesteryl esters. Freely deposited cholesterol in the membranes of the cells is cytotoxic. This deposition causes atherosclerosis, Alzheimer’s disease, Xanthelasma, etc. The first substrate for ACAT is both medium & long fatty acyl CoA. Therefore, we studied the ACAT enzyme, its active site, location and activity to develop the inhibitors of ACAT as antihyperlipidemic agents with the heterocyclic compounds for drug designing. ACAT is having two active sites: histidine and aspargines. ACAT 1 is present in two chromosomes 1 and 7. Active site His-460 Of ACAT-I is responsible for catalysis. For docking studies these factors should be known so that the hetercyclic compound could be developed having inhibitory activity against ACAT. Further many literature review have been done to find a hetercyclic moiety having the antihyperlipidemic activity in which we found that benzene ring with thiazole and oxazole rings having side chain could get...
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Posted by admin on Jun 30, 2022 in |
Alzheimer’s (AD) has been the most prevalent kind of dementia, generally producing linguistic and visuospatial deficits, frequently combining comfort ability problems such as apathy, aggression and depression, via the gradual deterioration of the episodic memory and learning. A noteworthy pathophysiological cause is the presence in the neuronal cytoplasm of extracellular plaque of insoluble ß-amyloid Peptide (Aβ) and neurofibrillary (NFT) tangles containing hyperphosphorylated tau protein (P-tau). Genetics could be linked to approximately 70% of the probability of development of AD. In the present study, the efficacy of ethanolic extract of Annona squamosa leaves (ASE) was evaluated against scopolamine-induced Alzheimer in the Wistar albino rat. Donepezil at dose of 2.5 mg/kg, ASE was given in rat at a dose of 100 mg/kg body weight, 200 mg/kg body weight and 300 mg/kg body weight. Anti-Alzheimer activity was assessed by Morris water maze, Novel object recognition test and Y-maze. And by biochemical test like neurotransmitter Acetyl cholinesterase activity, catalase activity, malondialdehyde and Nitric oxide assays. Results showed that extracts treatment prevents Alzheimer and...
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Posted by admin on Jun 30, 2022 in |
The solid lipid nanoparticles are sub-micron colloidal carriers (50-100 nm) that are composed of physiological lipid dispersed in water or in aqueous surfactant solution. Nadolol-loaded SLNs were prepared by modified high shear homogenization. It was observed that all formulations contain a good product yield. The highest drug content was found in formulation F5 98.37%. Entrapment efficiency for formulation F5 (98.58 %) was maximum. F5 formulations have lowest particle size (151.76) and the lowest PDI value (0.12) good Zeta potential (-28.8). The dissolution data of Nadolol solid lipid Nanoparticles F5 formulation was shown maximum drug release at 30 min. i.e., 99.04%. Hence, F5 was concluded as an optimized formulation for solid lipid nanoparticles (Nadolol-loaded SLNs F5 formulation). The present work aimed at preparing oral film with a quick onset of action, which is very convenient for oral administration. Oral fast-dissolving films of Nadolol SLN were prepared using HPMC (E5) as film-forming polymer and PEG 400 as a plasticizer by solvent casting method. Dissolution of prepared oral films of Nadolol was...
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Posted by admin on Jun 30, 2022 in |
Medicinal plants provide numerous benefits to human health. Mussaenda frondosa Linn belongs to the Rubiaceae family, which has 500 genera and 5300 medicinal plant species. Mussaenda is a flowering plant genus with many beautiful species. Ayurveda, an ancient Indian healing system, describes many herbs, oils, and minerals. People have known about plants’ medicinal value since prehistoric times. Mussaenda contains many medicinal natural compounds such as steroids, triterpenes and flavonoids. The chief chemical constituent present in the whole plant is butanedioic acid, diethyl ester, caryophyllene, hexadecanoic acid, quinic acid, 4-((1E)-3-Hydroxy-1-propenyl)-2-methoxyphenol, Naphthalene, decahydro2-methoxy, 1, 2, 3-Benzenetriol, alkaloids, flavonoids, saponins and tannins. Mussaenda frondosa nanocomposite enhances bioavailability and therapeutic potential. The present review compiled data on the importance of plants and their treatment options. This paper will be very useful to those in the medical, therapeutic, pharmacognosy and pharmacology fields. This article examines the genus Mussaenda and its phytochemical and pharmacological properties....
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Posted by admin on Jun 30, 2022 in |
Xanthene (or 9H-xanthene) is a parent active compound in which a pyran ring is combined with a benzene ring on both sides, whereas in thioxanthene, the oxygen of xanthene is replaced by a sulphur atom. Xanthene and thioxanthene are important classes of organic compounds which exhibit diverse pharmacological activities such as anti-spasmodic, anti-parkinsonian, anti-psychotic, anti-rhinitic, anti-inflammatory, anti-asthmatic, anti-ulcer, etc. This review covers various methods of synthesis of Xanthene and Thioxanthene. The pharmacoeconomic consideration of various marketed products of Xanthene and Thioxanthene are also discussed. It also covers the ongoing clinical trials of the upcoming Xanthene and Thioxanthene-based products and the newer indication of existing drugs. This review would be of immense use to researchers interested in Xanthene and Thioxanthene-based drugs. This review also helps the physician to preferably prescribe the cheaper brand for the patient’s benefit with the help of pharmacoeconomic analysis discussed in the...
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