Posted by admin on Jun 30, 2022 in |
The epidemiology, pathophysiology, clinical capabilities, diagnosis and scientific route of rheumatoid arthritis (RA) and the function of disorder-editing anti-rheumatic tablets (DMARDs) in its remedy are reviewed. RA, a giant disorder affecting humans of all races and sexes around the sector, has an unknown and perhaps multifactorial etiology. Conflicting proof supports RA’s immune-complex, infectious, metabolic, or genetic foundation. The sickness impacts arthrodial joints and starts as an immune reaction to unknown antigenic stimuli. A proliferative process ensues, leading to the formation of a vascular lesion referred to as a pannus, which then infiltrates into cartilage, subchondral bone, and tendon. This detrimental segment ends in traditional RA signs of pain, the predicament of motion, swelling, warmth, and redness of the affected joint. Symptoms and laboratory checks form the basis for prognosis. For maximum RA sufferers, a conservative remedy presents a significant advantage. More competitive intervention is vital to prevent everlasting incapacity in those sufferers who suffer from unrelenting and regularly negative sickness. The DMARDs are reserved for treatment of this institution...
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Posted by admin on Jun 30, 2022 in |
This work aims to evaluate the antimicrobial potential of ethanol, methanol, and water extracts of cherry (Prunus avium) and acetone extracts of quince (Cydonia oblonga), hexane & ethyl acetate extracts of Handh (Taraxacum officinale), acetone & methanol extracts of sustchal (Malva neglecta) of the selected minor fruits and vegetables of Indian Himalayan Region. Agar well diffusion method has been used to determine the antimicrobial activities and minimum inhibitory concentrations (MIC) of different plant extracts against Gram-positive (Staphylococcus aureus), Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and two strains of fungus (A. niger, A. flavus). The extracts exhibited both antibacterial and antifungal activities against tested microorganisms. The concentration increase of the extracts resulted in the increase of inhibition zone values resulting in the increase in the antimicrobial activities of the extracts. Both pulp and peel of Quince (Cydonia oblonga) exhibited significant antimicrobial activity. Acetone Quince (Cydonia oblonga) and Handh (Taraxacum officinale) extract showed significant antibacterial activity (P < 0.05) against all tested bacterial...
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Posted by admin on Jun 30, 2022 in |
Diabetes mellitus is a metabolic disorder caused due to lack of insulin and/or its insufficiency. It is ranked ninth among the leading causes of death globally. As Oral hypoglycemic agent usage causes one or more side effects, phytochemicals can be used as alternative herbal medicine to treat diabetes mellitus with little or no side effects. In the current study, Cuminic acid was evaluated for its antioxidant and antidiabetic activities under in-vitro. Different doses of Cuminic acid were used to analyze free radical scavenging effect by DPPH, H2O2 & NO methods. α- amylase and α- glucosidase inhibitory effects were studied using various doses of Cuminic acid. Glucose diffusion inhibitory assay was carried out using a Dialysis bag. In the results of the antioxidant study, Cuminic acid showed the highest free radical scavenging activity in all the methods compared to standard Ascorbic acid. Enzyme inhibition studies also showed significant increase in antidiabetic activity indirectly with increasing concentrations of Cuminic acid, which was found to be equivalent to the standard drug acarbose....
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Posted by admin on Jun 30, 2021 in |
Introduction: Anemia in CKD occurs when the kidneys are damaged or diseased. They cannot make enough EPO, which stimulates the bone marrow to produce RBC. It is associated with increased cardiovascular diseases, hospitalization, reduced quality of life, cognitive impairment, and mortality. Materials and Methods: A prospective observational study was conducted on CKD patients. Demographic details, treatment information, SES, and performance of daily activities were collected from the patients. Anemia was confirmed in patients by observing laboratory investigations, SES was collected by using the Modified Kuppuswamy scale, and the performance of patients for the treatment was analyzed by using the Karnofsky performance index. Results: The majority of the patients affected with anemia belong to UL Class. The performance of patients was improved as well as an increase in hemoglobin levels and decreases in Serum Creatinine levels were observed. P-value calculated for Haemoglobin, and serum creatinine was < 0.0001, which indicates the treatment was statistically significant. Conclusion: The pharmacotherapeutic treatment prescribed for anemia in various categories of CKD patient’s shows significant...
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Posted by admin on Jun 30, 2021 in |
This study was conducted to investigate the antibacterial activity and rate of kill of the various partially purified fractions of Spondias mombin’s leaf extract on selected pathogenic bacteria. Fresh leaves of Spondias mombin were air-dried and then ground into fine powder. The powdered leaves of Spondias mombin were extracted using ethanol-water in the ratio 1:1 (v/v). The crude extract was fractionated by partial purification using various solvents such as n-hexane, chloroform, ethyl-acetate, and n-butanol. The fractions were concentrated in vacuo and lyophilized. Afterward, the different fractions were tested for antibacterial activities against selected pathogenic bacteria using the agar well diffusion method. The minimum inhibitory and minimum bactericidal concentrations were determined using the standard microbiological method. The rate of kill of the test isolates by the active fractions (n-butanol, ethyl acetate, and n-hexane fractions) was also determined. The zones of inhibition shown by the active fractions at 15 mg/mL on the isolates ranged between 11.7 mm and 15.7 mm while the minimum inhibitory and minimum bactericidal concentrations of the active...
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