Posted by admin on Jul 31, 2015 in |
Currently there has been an increased interest in using iontophoretic technique for the controlled transdermal drug delivery of medicines, especially in the delivery of proteins & peptides through skin membranes. The delivery of ionic drug molecules and peptide/protein molecules through transdermal delivery to attain a systemic therapeutic effect, chemical or physical methods are needed to improve the rate of penetration of therapeutic drug molecule through the main diffusion barrier present in the skin membrane. In that, the iontophoretic technique is one of the most desirable to enhance the transdermal drug delivery of high molecular weight substances like peptide and proteins using a lower current intensity with a short time period for the desired therapeutic effect. This article is an complete overview of the controlled transdermal drug delivery of ions/proteins/peptides by iontophoresis as well as the principles, laws, mechanisms, factors, design considerations, applications, advantages, limitations of transdermal iontophoretic drug delivery...
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Posted by admin on Jul 31, 2015 in |
Diabetes mellitus (DM) was found to impair all dimensions of health except mental health and pain and in a more recent multinational study, DM was found to have a notable impact on general health, measured using the Medical Outcomes Short-Form 36 (SF-36). A cross-sectional, randomized study conducted in Ajman and Sharjah, October 2012 to May 2013, using a self-completed questionnaire and SF-36 health related quality of life (HRQL) questionnaire by 150 diabetic patients on different types of medications and 220 control subjects. Forty four percent of patients used Insulin for their treatment, 34% used Metformin, 14.7% used combination therapy of Insulin with Metformin and only 6% used Gliclazide. The mean values of Physical Functioning (PF), Role-Physical (RP), Bodily Pain (BP), General Health (GH), Vitality (V), Social Functioning (SF), Role Emotional (RE), Mental Health (MH), Physical Components Summary (PCS), and Mental Components Summary (MCS) scores were 61.2, 19.5, 59.2, 56.5, 53.0, 55.4, 57.3, 55.6, 4, and 42.1, respectively. Patients taking an oral therapy had better quality of life than those...
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Posted by admin on Jul 31, 2015 in |
L-asparaginase is responsible for the hydrolysis of L-asparagine into L-aspartic acid and ammonia. L-asparaginase is used as an effective therapeutic agent against lymphocytic leukemia. It also finds applications in food industry. Though much has been unraveled about LA, it may appears today that it is at the tip of iceberg and there is tremendous scope in screening of novel LA sources and studying their properties and applications. In the current study L-asparaginase producing bacteria were screened from forest soil of Vasai, MS, India. Modified M9 medium was used for screening the L-asparaginase producers. Out of the total 885 organisms screened for L-asparaginase production, one isolate was found to produce substantial L-asparaginase (15.94 IU/ml). This isolate was further identified by 16S ribosomal RNA gene sequencing as a novel strain Salinicoccus sp. M KJ997975. This orange pigment producing isolate was found to be moderately halophilic and alkaliphilic. Not much literature is available on L-asparaginase producing gram positive alkalophilic and halophilc bacteria and this is the first kind of report on L-asparaginase...
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Posted by admin on Jul 31, 2015 in |
The oral route is easiest and most convenient route for drug administration. The major problem in oral drug formulations is low and erratic bioavailability, which mainly results from poor water solubility. This may leads to higher inter subject and intra subject variability and therapeutic failure. The improvement of compounds solubility and bioavailability are the greatest challenges in formulations. The self emulsifying drug delivery system (SEDDS) is a novel approach for enhancing the solubility of formulations; by this approach it is also possible to prolong the release of drug via incorporation of polymers in SEDDS composition which appears to be unique and industrially feasible approach. The SEDDS is an isotropic mixture of oils, surfactants, co-surfactants, co-solvents, etc. It can be used for designing the formulations such as tablets, capsules, pellets, etc. The SEDDS will continue to enable novel applications in drug delivery and solve problems associated with the delivery of poorly soluble...
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Posted by admin on Jul 31, 2015 in |
The contents of Sodium lauryl sulphate (SLS) and Polysorbate (Tween 80) were studied in different formulations of Nebivolol film coated tablets. The contents were extracted using the diluent Methanol: Water in the ratio 60:40 v/v and analyzed in HPLC coupled with Evaporative light scattering detector (ELSD). SLS and Tween 80 are solubilizing agents and the amount of these contents are critical in formulations as they are play a major role in the release pattern of the drug for in-vivo and in-vitro dissolution profiles. A reverse phase liquid chromatographic (RP-LC) method was developed for the quantification of Sodium lauryl sulphate (SLS) and Polysorbate (Tween 80). The method was optimized using buffer (prepared by dissolving 0.77g of Ammonium acetate taken in 2000mL milli-Q-water and then pH was adjusted to 4.5with dilute acetic acid solution) as mobile phase-A and Acetonitrile mobile phase-B. The flow rate was set at 1.0 mL min-1 and the column temperature was maintained at 40°C. The capability of specific method developed was demonstrated by studying the validation parameters...
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