Posted by admin on Jul 31, 2015 in |
Warfarin, a vitamin K antagonist has been the leading oral anticoagulant since early 1940s despite limitations like slow onset and offset of action, variations in metabolism, multiple food and drug interactions, narrow therapeutic index and need for routine laboratory monitoring. Rivaroxaban, a direct factor Xa inhibitor is a recently introduced orally effective novel anticoagulant offering improvement over current standard of care such as good bioavailability, low propensity for food and drug interactions, rapid onset of action, ease of administration, wide therapeutic index, predictable anticoagulant response and fixed oral dosage, limited side effects and no inter subject variability. Over and above, the drug doesn’t require coagulation monitoring. Thus rivaroxaban has the potential to be an attractive alternative to current anticoagulants, providing effective and well tolerated anticoagulation in a convenient manner in patients with stroke and systemic embolism with non-valvular atrial fibrillation (AF), treatment and prevention of deep vein thrombosis (DVT), pulmonary embolism (PE) etc. Moreover, specific antidotes (Aripazine-PER 977; Ciraparantag) and Andexanet (PR TO64445) antagonising the pharmacodynamic effect of rivaroxaban...
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Posted by admin on Jul 31, 2015 in |
A new series of s- triazine based chalcones have been synthesized by the temperature controlled reaction. The first substitution occurs at low temperatures (0°C), the second substitution at approximately at room temperature (25-30°C) and the third at elevated temperatures (70-100°C). This property allows substitution of three different neucleophiles onto the same triazine core which provides a vast array of possible triazine...
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Posted by admin on Jul 31, 2015 in |
The bioactive components of Bryonopsis laciniosa fruits have been evaluated using GC/MS. The chemical compositions of the methanolic extract of Bryonopsis laciniosa fruits were investigated using Perkin-Elmer Gas Chromatography –Mass Spectrometry, while the mass spectra of the compounds found in the extract was matched with the National Institute of Standards and Technology (NIST) library. The GC-MS analysis shows that the most prevailing compounds were identified as Oleic Acid, Hexanoic acid, 2-Ethylcyclohexanone, 2-Methyltetracosane, 2-Undecenal, 1,2-Benzenedicarboxylic acid, Ascorbic acid 2,6-dihexadecanoate, Octadecanoic acid, (2E)-2-Decenal.The compounds like Sulfurous acid, n-Nonaldehyde, 2-Hepten-3-ol, Decadienal, 3-Octenoic acid, 1-[2-(acetyloxy)ethyl]-3-oxooctyl acetate $$ acetic acid 3-acetoxy-5-oxo-decyl ester, 9-Octadecenoic acid, 2H-Pyran-2-one, Z,Z-4,15-Octadecadien-1-ol acetate were moderately present. The results confirm the presence of bioactive components which are known to exhibit medicinal value as well as pharmacological...
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Posted by admin on Jul 31, 2015 in |
Larrea divaricata Cav. commonly known as “jarilla hembra” is used in folklore medicine as anti-inflammatory. There was no scientific evidence justifying the medicinal use of the aqueous extract for inflammation diseases. Nowadays, there are two principal types of anti-inflammatory drugs: Steroidal anti-inflammatory drugs (corticosteroids) and non-steroidal anti-inflammatory drugs (NSAIDs), which exert gastrointestinal ulceration and bleeding. In this work the preventive anti-inflammatory activity of L. divaricata aqueous extract (AE) in C3H/He mice was determined by carrageenan- induced inflammation and ear edema tests, also its toxicity on gastric tissues and on blood cells was studied. The chromatographic profile showed: nordihydroguaiaretic acid (NDGA) as majority compound. AE exerted anti-inflammatory action without inducing gastric or blood cell toxicities. Also, it could modulate anti-inflammatory and pro-inflammatory cytokines. NDGA was not the compound responsible of the anti-inflammatory action. This work rescues the potentiality of AE as a gastric and blood cells innocuous anti-inflammatory agent and confirms its ethno- pharmacological...
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Posted by admin on Jul 31, 2015 in |
In today’s hectic lifestyle, such dosage form as plaster, attracts more attention of scientists and gives new opportunities to use it in medicine. The purpose of our study was to investigate consumer properties of transdermal patches, hold the commodity analysis of the dosage form and determine the prospectiveness of their use in modern pharmacotherapy. Market review has been conducted. Analyzed the producing countries of transdermal patches reported on the pharmaceutical market of Ukraine. An analysis of the active ingredients used in the TTS has been carried out. Modern classifications of transdermal therapeutic systems have been given. The approaches to creation of TTS have been investigated. The most important consumer properties of TTS have been...
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