Posted by admin on Jul 31, 2018 in |
The study was conducted to evaluate the synergistic effect of EDTA with antibacterial (Ceftriaxone + Sulbactum) as a combinational therapy against antioxidant enzyme activity, lipid peroxidation level, some hematological and biochemical parameters in Klebsiella pneumoniae induced nosocomial pneumonia followed by histopathology of lungs tissue in experimental exposed Sprague Dayle (S.D) rats. Total 24 rats were selected and divided into 4 groups of 06 rats each for in-vivo and in-vitro EDTA / antibacterial therapy. Group I Control normal saline treated group; group II was infected via K. pneumoniae bacterial strain. Group III and IV were infected plus treated group with antibacterial and EDTA / Antibacterial drugs. The results indicated that a significant (p<0.005) decrease in enzymes activities (Superoxide dismutase, catalase and ascorbic acid) along with increased lipid peroxidation level as well as cytokine parameters (tumour necrosis factor-α, interlukin-6) and biochemical parameters in plasma of infected group as compared to control group. These activities were increased along with decreased in lipid peroxidation level and biochemical parameters in both treated group as...
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Posted by admin on Jul 31, 2018 in |
The oral delivery of hydrophobic drugs presents a major challenge because of the low aqueous solubility of such compounds. Self-emulsifying drug delivery systems (SEDDS), which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds. SEDDS can be orally administered in soft or hard gelatin capsules and form fine relatively stable oil-in-water (o/w) emulsions upon aqueous dilution owing to the gentle agitation of the gastrointestinal fluids. The efficiency of oral absorption of the drug compound from the SEDDS depends on many formulation-related parameters, such as surfactant concentration, oil/surfactant ratio, polarity of the emulsion, droplet size and charge, all of which in essence determine the self-emulsification ability. Thus, only very specific pharmaceutical excipient combinations will lead to efficient self-emulsifying systems. Although many studies have been carried out, there are few drug products on the pharmaceutical market formulated as SEDDS confirming the difficulty of formulating hydrophobic drug compounds into such formulations. At...
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Posted by admin on Jul 31, 2018 in |
The adverse effects of oxidative stress have been discussed widely in the present day. It is the main cause of protein denaturation, cardiovascular diseases, ageing, etc. Thus, the daily requirement of anti-oxidants has to be fulfilled through dietary sources. Inflammation is yet again another form of stress on the body. It is the major cause of multiple chronic disorders. It can lead to the formation of many other disorders such as arthritis, asthma, macular degeneration, etc. Arthritis is one such inflammatory disorder which is associated with swelling of joints, joint pain, etc. This research was based on the anti-oxidant, anti-inflammatory and anti-arthritic properties of tea extracts such as Camellia sinensis, Hibiscus rosa sinensis, Rosa, Zingiber officinale, Matricaria chamomilla. Ex-vivo tests for evaluating antioxidant property of samples using liver tissue by LPO assay was performed. In addition, tests such as inhibition of protein denaturation and RBC membrane stabilization were performed to determine anti-inflammatory effect of the sample. Collagen denaturation assay using chicken collagen to check anti-arthritic properties of samples were...
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Posted by admin on Jul 31, 2018 in |
The objective of the present study is to investigate the adverse effect of chloroquine (CQ) toxicity on reproductive tissues and its attenuation by curcumin. Chloroquine (CQ) has been used widely as an antimalarial drug due to its quick action on blood schizontocide of different malarial parasite species for prophylaxis and treatment of malaria. Thirty-six male mice were divided into six experimental groups: control, curcumin (80 mg/kg b.w.), CQ low dose (100 mg/kg b.w.), CQ mid dose (200 mg/kg b.w.), CQ high dose (300 mg/kg b.w.) and CQ high dose + curcumin treated group. An oral dose of artesunate and curcumin was administered for a period of 14 and 21 days to male Swiss albino mice. Results obtained indicated significant alterations in biochemical parameters as well as energy metabolism parameters in testicular tissue of animals after the treatment with chloroquine. Moreover, sperm count, sperm motility percent, sperm viability and sperm morphology of cauda epididymis of chloroquine treated mice revealed significant fluctuations as compared to the control group. Administration of curcumin...
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Posted by admin on Jul 31, 2018 in |
The traditional Siddha system of medicine has its origin in South India, and it deals with the well being of human race from neonates to Geriatrics. Presently there is an emerging increase in research and publications regarding the evaluation of traditional medicines primarily based on phytochemical, pharmacological, sophisticated instrumental analysis including various in vitro and in-vivo studies. Still there exists a gap area in the analysis of ancient literature which is the backbone on which the antique system of medicine such as Siddha exclusively stands. Kiranthi is an ancient Tamil term that is mentioned in the Siddha literature under Karuvil thondrum noigal (Diseases due to intra uterine factors). The prevention and management of Pediatric diseases have been dealt in the Siddha literature. Though these literature were written by ancient sages of South India thousands of years ago, it is quite interesting to know that parallel analysis of these age old poems have revealed its correlation with modern neonatological texts and terminologies. Therefore, this literature analysis was undertaken to compare...
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