Posted by admin on Jul 31, 2018 in |
With the advent of nanotechnology, it has become important to realize the immense potential of ayurvedic bhasma which had been there for centuries. The study of ayurvedic bhasma as nanomedicine is an important interdisciplinary research area in need of contributions from material science, chemistry, pharmacology, etc. Such a research will definitely help in the characterization and standardization of these bhasmas which is a very complex problem. However, this system is not getting recognition in other parts of the world. Among the various reasons listed for lack of popularity of ayurveda, is non-availability of ‘standards’ for ayurvedic medicine particularly when prepared on large scale in modern pharmaceutical plants, matching the convenience palatability of modern dosage forms. Many times, it is reported that the preparation, particularly those mineral based are found to contain toxic substances exceeding permissible limits. There has been a lot of hue and cry regarding the safety and efficacy of the bhasmas, especially after publication of certain reports in print media. Further, the commercial pharmacies not adhering to...
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Posted by admin on Jul 31, 2018 in |
The objective of current study was to develop self-nanoemulsifying drug delivery systems using long-chain triglycerides of resveratrol to enhance its bioavailability. Solubility studies performed in different lipids, surfactants and cosurfactants. Phase diagrams constructed to select areas of nanoemulsion. SNEDDS formulation optimized using 33 central composite design (CCD) considering lipid (X1), surfactant (X2) and co surfactant (X3) as critical variables and optimized formulation was located using overlay plot. The nanometer size and high values of zeta potential depicted non-coalescent nature of SNEDDS. Resulted SNEDDS formulation improved in vitro release followed by Hixson Crowell model with higher regression R2 value 0. 929. Thermodynamic stability studies ascertained stable formulation. Mean droplet size in selected nanocarrier was found to be 83.29 nm. The nanocarriers showed enhanced bioavailability in albino rabbits when compared to pure drug. The novel approach developed by selecting optimum blends of lipids, surfactants and cosurfactant using central composite...
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Posted by admin on Jul 31, 2018 in |
The pretentious extract of Pseudomonas aeruginosa has shown promising anticancer activity. It contains a protein called Azurin. It has a molecular weight of 14 kDa. It is soluble in water. It is a type I copper-containing protein of cupredoxin family. In this work, Pseudomonas aeruginosa MTCC strain 647 was cultivated in modified Asparagine -proline broth. An attempt was done to isolate and purify azurin from Pseudomonas aeruginosa (MTCC 647) by using chromatography on sephadex G, CM cellulose and SDS PAGE electrophoresis. Recent studies have found that Pseudomonas aeruginosa can synthesize nano particles through either intracellular or extracellular mechanisms by bio synthetic means. Hence, the composite nano particles (Azurin-Ag NP) were synthesized by biosynthetic methods. P. aeruginosa MTCC strains 647 was cultivated in modified Asparagine -proline broth initially to produce shake flask cultures and then fed batch cultivation. From the bacterial extracted Azurin is isolated and purified to get a final concentration of 4.6 mg/g dry bacteria. As the nano particle mediated drug delivery effectively deliver the drug to the...
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Posted by admin on Jul 31, 2018 in |
A series of tetrazol derivatives 1(a-c) and 2(a-c) were synthesized by Mannich base reaction. Synthesized compounds 1(a-c) and 2(a-c) were confirmed by IR, ¹H NMR, ¹³C NMR, mass spectral, and elemental analysis. Synthesized compounds 1(a-c) and 2(a-c) were screened for dental plaque bacteria and cytotoxicity activity. The compound 1b was highly active against Enterococcus feacalis in antibacterial screening. The synthesized compounds have been screened for preliminary cytotoxicity against HepG2 (Liver), Hela (Cervical) and MCF-7 (Breast) cancer cells. The compound (1c) is highly active against MCF-7(Breast), and compound (2b) is highly active against HepG2 (Liver). Therefore, current study demonstrates the antibacterial and cytotoxicity activity potential of new tetrazole derivatives and provides future insights for developing dental plaque antibacterial...
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Posted by admin on Jul 31, 2018 in |
The objective of the present study was to evaluate the effect of microwave sintering condition on matrix formation and subsequent drug release from polymer matrix tablet for controlled release. The Atenolol floating SR matrix tablets were prepared by using tragacanth, sodium bicarbonate, Eudragit S-100 and citric acid was incorporated as a gas generating agents. Atenolol controlled release tablets were estimated in terms of their physico-chemical parameter like weight variation, friability, hardness, drug content, contact angle, floating lag time in-vitro drug release, specific gravity and stability study as per ICH guidelines. The results of in-vitro drug release studies showed that the optimized formulation (F6, L2, I2, H4) could extend drug release (99.5%) for 24 hours. The release pattern of Atenolol was fitted to different models based on coefficient of correlation (r). The present work also deals with the application of sintering technique to matrix tablets of Atenolol to achieve sustained release. The results of the present work stated that sintering caused decrease in drug release as compared to unsintered tablets....
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