Posted by admin on Aug 31, 2023 in |
Flavones make up one of the biggest subgroups of the secondary metabolite class of flavonoids, which has more than 9000 known structural variations. It is shown that they are present in practically all plant tissues naturally. In the literature, many flavone aglyca and their O- or C-glycosides have been described. Numerous potential uses exist for flavones due to their wide range of biological activities in plants and their numerous interactions with other species. These include plant breeding, ecology, agriculture, human nutrition, and pharmacology, in addition to plant breeding. Flavones are abundant polyphenols of plant origin that have been extensively studied for their pharmacological properties. Flavones are a subclass of flavonoids with their structural basis in 2-phenylchromen-4-one (flavus = yellow). Cereals and plants are the primary sources of flavones. Since flavones are physiologically active substances, several synthetic techniques have been developed. We have attempted to include a variety of synthetic methods for the synthesis of flavones in this update. Claisen-Schmidt condensation and Baker-Venkatraman synthesis are two well-known techniques for creating...
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Posted by admin on Aug 31, 2023 in |
Hypertension, also known as high blood pressure, occurs when the force of blood against the artery walls is excessively high the force of blood against the artery wall is too high. Hypertension is a very common disorder, particularly in past middle age. For improvement activity of hypertension, Azelnidipine and Telmisartan are newer combination in the market which is effective in hypertension. This combination was developed to improve medication for stage II hypertension. Azelnidipine is a Calcium channel blocker, and Telmisartan is an Angiotensin II receptor blocker. This review provides information about different analytical methods for estimating Azelnidipine and Telmisartan individually or in combination with other drugs, such as UV spectrophotometry, HPTLC, HPLC, and LC-MS. All reported methods were found to be simple, accurate, economical, precise, and reproducible. This review focuses on the recent analytical method development of Azelnidipine and Telmisartan in their combined dosage form. It also includes a stability-indicating analytical method for determining Azelnidipine and...
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Posted by admin on Aug 31, 2023 in |
N. sativa (black cumin seed) is popularly known for its medicinal significance such as Anticancer, Antioxidant, Anti-microbial, Anti-inflammatory, Anti-ulcer, Anti-parasitic, Anti-histamine, Analgesic, for skin rashes, hair treatment and also used as a flavoring agent. Recent reports reveal that the Nigella sativa seeds exhibit a potent effect on the Covid-19 virus. Further, N. sativa seed can be used to reduce weight as well as increase digestion. In this manuscript, the recent medicinal updates are highlighted. Finally, this review may attract the young researcher to further design and development of the...
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Posted by admin on Aug 31, 2023 in |
The PI3K-AKT-mTOR signaling pathway is widely used in cancer therapy as it is a signaling pathway that is frequently disrupted in human cancers. Increasingly, inhibitors develop against key proteins in signaling pathways, such as PI3K and mTOR. Dual inhibitors targeting PI3K and mTOR are more potent than one inhibitor targeting only a single protein. This study used to design and molecular docking analysis to investigate the precise binding positions and interaction forces of quinoxaline-containing compounds within the active site of PI3Kγ and mTOR with the help of freely available software for virtual screening of compounds, docking, and drug interaction result analysis. And also proposed the development of new potent drug candidates which works as dual inhibitors against cancer diseases; thus it could be concluded that Quinoxaline-containing derivatives might be used as a template for destiny improvement thru change or derivatization to lay out stronger healing...
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Posted by admin on Aug 31, 2023 in |
Pseudomonas aeruginosa is a Gram-negative pathogenic bacterium that can cause a variety of hospital-acquired diseases. It is a multidrug-resistant bacterium and can survive a wide range of antibiotics; hence there is a concern about its limited therapy options. In this scenario, the discovery and development of novel antibiotics are in high demand. In our research work, molecular docking a Bioinformatics technique, is applied to find the ideal lead molecule from plants. For this study, we have extracted literature-proven phytocompounds from a variety of traditional medicinal plants and their structures were retrieved from the PubChem database. Lipinski and ADME/TOX screening were used to evaluate drug likeliness, followed by docking against the target protein. Pseudomonas aeruginosa elastase, or LasB is a virulence protease that hydrolyzes host tissue and is thus considered the target protein. Elastase degrades human skin extracellular protein in wound infections, including tissue damage and inflammation. Thus, elastase could be a promising target for the discovery of novel lead compounds. As a result of docking studies, Eupalitin 3-o-galactoside, a...
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