Posted by admin on Sep 1, 2013 in |
Oral bioavailability of Simvastatin is very low (5%) due to bad solubility and effect of first pass. The aim of this work is to enhance its solubility and reformulating it as orodispersible tablet to overcome the two problems. Simvastatin solid dispersions in β- cyclodextrin, hydroxylpropyl-β-cyclodextrin, and hydroxylbutyl-β-cyclodextrin were prepared in different drug: polymer ratios namely 1:1, 1:2, and 1:3 by kneading and solvent evaporation methods. Solid dispersion formation and mixture compatibility was investigated by DSC and FTIR. Based on the results of solubility studies; the best solid dispersion formula was selected and formulated into orodispersible tablet using Emcosoy, K-polacrillin as novel superdisintegrants and mannitol, Pullulan as water soluble diluents and evaluated. The results showed that the increase in drug solubility was dependent on polymer type, concentration and also was affected by preparation method. Simvastatin-hydroxyl-butyl-β-cyclodextrin solid dispersion mixture prepared in 1:2 drug: polymer ratio by solvent evaporation method had a higher solubility. Orodispersible tablet formula prepared by Emcosoy as superdisintegrant, Pullulan as diluent showed least wetting and disintegration times (20...
Read More
Posted by admin on Sep 1, 2013 in |
In present work, a new vanishing cream using a natural base from palm oil and palm kernel oil and standard vanishing cream using stearic acid were prepared. The creams were o/w emulsions containing suitable combination of oil phase and aqueous phase along with preservatives. Both creams were white, non-greasy and smooth on application. They were subjected to various parameters such as; pH, viscosity, spreadability and tube extrudability. Stability studies of the prepared creams were determined at different temperatures for a period of 3 months as per ICH guidelines and the results revealed that both formulations were with good stability except the standard vanishing cream which was slightly hardened at 5oC. The pH was found to be 6.7 and 6.98, and spreadability was found to be 11.30g. cm/sec and 13.33g.cm/sec for natural base and stearic acid based creams respectively. The tube extrudability was found to be good and fair for natural base and stearic acid based cream respectively. Furthermore, the formulations were studied for primary skin irritation test on rabbits...
Read More
Posted by admin on Sep 1, 2013 in |
Biofilms are multicellular communities of bacteria. The ability to form biofilm is a universal attribute of bacteria and as bacteria can form biofilm in medical, industrial and environmental settings, it impacts human lives in many different ways. Bacteria undergo profound physiologic, morphologic and genetic changes as the transit from planktonic (free swimming, non-biofilm) form to surface attached biofilms. As bacteria in biofilm exhibit enhanced resistance to antibiotics and clearance by the host immune system, biofilm has been an intensely researched area for microbiologists, immunologists and pharmaceutical scientists alike. This review focuses on current knowledge on biofilm science, clinical relevance and virulence of biofilm, host response to it and therapeutic options to eradicate...
Read More
Posted by admin on Sep 1, 2012 in |
NLC are innovative vehicles introduced to overcome some limitations of SLN. Particularly, NLC, composed of a solid lipid and a certain content of liquid lipid (oil), show improved drug entrapment efficiency and an increased stability during storage with respect to SLN. Furthermore, NLC, maintaining their solid state, can control the API release from the matrix. To formulate Nanostructure lipid carriers of an anti-inflammatory drug Betamethasone Dipropionate. To conduct in vitro Diffusion studies using dialysis membrane. To Ex vivo permeation study using rat skin. To conduct stability studies at 4°C and room temperature and to evaluate entrapment efficiency at various time...
Read More
Posted by admin on Sep 1, 2012 in |
This study was designed to investigate the ameliorative effect effect of Hygrophila auriculata (H. auriculata) on lipid peroxidation (LPO) in N-nitrosodiethylamine induced Hepatocellular Carcinoma (HCC) in rats. Experimental rats were divided into different groups: normal, N-Nitrosodiethylamine induced hepatocellular Carcinoma bearing rats, H. auriculata treated hepatocellular carcinoma bearing rats, (200 mg/kg body weight, doses for 28 days), Animals treated with plant extract alone for 28 days. After the treatment period of 28th day , effect of H.auriculata on LPO in serum , liver and kidney of control and experimental animals were assayed and compared. Under basal and in the presence of inducers (H2O2), the levels of LPO were increased significantly (p<0.001) in group II cancer bearing animals where as the levels of LPO in the presence of ascorbic acid and FeSO4, were not statistically different. In group III plant extract treated animals, significant decrease on LPO was observed. However, the changes in the above parameters were comparable with control.Thus, methanolic extract of H. auriculata ameliorated the LPO which is associated...
Read More
