Posted by admin on Sep 1, 2011 in |
The aim of the current study was to develop once-daily sustained-release matrix tablets of metoprolol succinate, Selective β1– blocker used in cardiovascular diseases. The tablets were prepared by the wet granulation method. Ethanolic solutions of ethylcellulose (EC), polyvinylpyrrolidone K30 were used as granulating agents along with hydrophilic matrix polymer hydroxypropyl methylcellulose (HPMC K100M). The granules were evaluated for angle of repose, bulk density, compressibility index and drug content. The tablets were subjected to thickness, diameter, weight variation test, drug content, hardness, friability, and in vitro release studies. The granules showed satisfactory flow properties, compressibility, and drug content. All the tablet formulations showed acceptable pharmacotechnical properties and complied with in-house specifications for tested parameters. The results of dissolution studies indicated that batch AH3 (Drug-to-HPMC K100M, ethyl cellulose solution (4%W/V, as granulating agent) could extend the drug release up to 24 hours. Batch AH3 showed highest f2 value 84.95 and MDT 8.9 hrs similar to that of reference product. The dissolution data were subjected to model fitting analysis and best fitted...
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Posted by admin on Sep 1, 2011 in |
The present work deals with development and standardization of phytochemical screening for quantification of ethanolic extract of aerial part of the Luffa echinata Linn. The scientific parameter is necessary to identify the exact plant material and to find its quality and purity. The present study deals with various, physical evaluation and preliminary phytochemical screening of various successive extracts such as qualitative chemical analysis. HPTLC of extract shows the seven different peaks confirming that the seven compounds present in ethanolic extract of Luffa echinata. The alkaloidal content of aerial part of the plant has been determined. These studies indicated the possible information for correct identification and standardization of this plant...
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Posted by admin on Sep 1, 2011 in |
Labetalol Hydrochloride due to its pH dependant solubility in range of 6-10 shows 10-80% variability in bioavailability, used in treatment of hypertension. Due to its short half life i.e. 3-6 hrs, it is administered twice a daily. Therefore to improve bioavailability and patient compliance in this study attempt has been made to develop an oral floating tablet of Labetalol hydrochloride. An optimized floating drug delivery system (GFDDS) of Labetalol Hydrochloride was developed using simplex Centroid design. In this design Hydroxypropyl methyl cellulose K4M (X1), Carbopol 934P (X2), Sodium carboxymethylcellulose (X3) were used as independent variables and floating lag time,t50% and t80% as responses. In this design effervescent matrix tablets were prepared by combination of citric acid and sodium bicarbonate. Results of ANOVA indicated, low levels of X2 and X3, and high level of X1 should be used to manufacture the tablet formulations with desired in vitro floating time, t50% and t80%. Kinetics of drug release from tablet followed Korsmeyer–Peppas model by anomalous non-Fickian diffusion. It was concluded that gastro...
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Posted by admin on Sep 1, 2011 in |
The antibacterial activity of methanol extract of Borassus flabellifer L. (Arecaceae) seed coat (soft outer shell) was studied by agar well diffusion method in vitro. The tender seed coat of Borassus flabellifer was extracted with methanol. The effect of antibacterial potential was examined against Gram positive bacteria i.e., Staphylococcus aureus, Bacillus subtilis and Gram negative bacteria i.e., Klebsiella pneumoniae and Serratia marcescens. The methanol extract of the seed coat has showed consistently significant inhibitory activity on different bacterial species tested. Furthermore, the minimum inhibitory concentration studies carried out by broth dilution assay and found the MIC ranged between 100μg to 1 mg/ml implying the significance of antibacterial activity of Borassus...
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Posted by admin on Sep 1, 2011 in |
The stem and root barks, leaves and seeds of Millettia pachycarpa Benth. are used for various medicinal purposes in Chinese and Mizo traditional practices. The plant extract reportedly showed potent vermicidal activity on cestodes. The ethanol extract of the root bark was tested against the poultry nematode, Heterakis gallinarum Schrank. In vitro treatment at 37±1°C revealed that a serial dose of the plant extract caused dose-dependent vermicidal effect on the worm (significant efficacy at P<0.05), except at the lowest dose (i.e. 5 mg/mL). A broad-spectrum drug albendazole also exhibited similar effect but with higher potency at all doses applied. The nematode treated with 80 mg/mL of the plant extract caused apparent destruction on the morphological structure, mostly of severe distortion in the cuticular organization throughout the body topography. Collapse of the lips and contraction of the body proper with prominent folding of the cuticle at the cephalic region were clearly discernible. At the posterior end were also extensive disintegration of the cuticle along with shrivelled cloacal mount and caudal...
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