Posted by admin on Sep 1, 2010 in |
The optimization of this study is biochemical effect of protein in Liver, Kidney, Uterus and Ovary of albino rats (Sprague-dawley strain) weighing about 200-250gm treated orally of ethanolic extract of plant Tridax procumbens at 300mg/kg body weight concentration for 3 and 5 days chronically. The result showed that both treated groups of rats are not showing very significant changes in protein content of Liver, Kidney, Uterus and Ovary of rats as compared to their control groups. Therefore, it is safe to use it against various...
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Posted by admin on Sep 1, 2010 in |
Synthesis of some aldehyde derivatives of 1, 4 di- hydro pyridine has been done. The entire synthesized compounds were characterized by UV, IR and 1HNMR spectroscopy. The anticonvulsant and antimicrobial activity were also evaluated. The present investigation deals with the synthesized compounds possessing good anticonvulsant, analgesic and antimicrobial activity. Synthesized compounds like PNH, PNA, ONF, MND, PAH posses significant anti convulsant activity. However, all the compounds showed analgesic activity less than the reference standard. Anti bacterial activities of the compounds were evaluated against staphylococcus aureus and the zone of inhibition was measured as the parameter of activity. Amikacin, the standard showed a zone of inhibition of 18 mm out of 8 synthesized compounds only one PNN (Ia) compound showed an equal activity when compared with standard. In which (ONF, PAN) showed considerable anti bacterial activity. The remaining four compounds PNM, MNC, MNA, PAK showed moderate antibacterial activity. Anti bacterial activity of the compounds were evaluated against E. Coli and the zone of inhibition was measured as the parameter of...
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Posted by admin on Sep 1, 2010 in |
The study is aimed at development of physicochemical parameters and to investigate the active principle present in Tridax Procumbens Linn. Tridax Procumbens Linn. (Asteraceae) commonly known as Coat Buttons is an important plant used against various disorders in indigenous system of medicine such as Wound-Healing, Hepatoprotective, Anti-Inflammatory, Anti-diabetic and Immunomodulatory activities. Thus from the extensive literature survey it was revealed that no reports were available on microscopic evaluation, standardization parameters and chemo profile of Tridax Procumbens to check the identity and purity of the drug. The present work embodies the investigations carried out to establish methods for quality control of drugs as per WHO guidelines: complete botanical evaluation which comprises macroscopic, microscopy physicochemical parameters like loss on drying extractive value, ash value and to investigate the Phytochemical present the extract in the preliminary level were carried out for the quality control of the drug. Thus it was thought worthwhile to explore this endangered plant on the basis of this standardization parameter. The study will provide referential information for the...
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Posted by admin on Sep 1, 2010 in |
Alzheimer’s disease, a synonym for life threatening dementias is characterized by oxidative stress and neuroinflammation induced neuronal loss, impaired energy metabolism, and cholinergic deficit leading to severe cognitive impairments and other abnormal neuropsychiatric changes. Cholinergic hypothesis is the most accepted theory explaining pathology of AD and Acetylcholinestrase inhibitors are the main stay of AD therapy. In the present study, the effect of Minocycline, a tetracycline derivative, was investigated against intracerebroventricular streptozotocin induced cholinergic deficits. Intracerebroventricular administration of streptozotocin (3mg/kg) bilaterally on day 1 and 3 was able to produce significant cholinergic deficits as evidenced by increase in level of acetylcholinestrase while chronic treatment with Minocycline (10, 20 and 40mg/kg, i. p.) for 21 days significantly decreased it. The results of the present study support the candidature of Minocycline in learning and memory disorders resembling dementia of Alzheimer’s...
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Posted by admin on Sep 1, 2010 in |
The anti-allergic of an aqueous extract of the leaves of Ailanthus excelsa Roxb.(AELAq) was evaluated by using milk induced leucocytosis and eosinophilia in mice, passive paw anaphylaxis in rats models while the anticataleptic properties was evaluated by Clonidine induced catalepsy in mice mode. The extract significantly (*p<0.05, **p< 0.01) decreased the leucocytosis and eosinophilia along with passive paw anaphylaxis in the above experimental animals respectively. The extract also significantly (**p< 0.01) decreased Clonidine induced catalepsy in mice. These results suggest that aqueous extract AELAq may have the potential therapeutic value in the treatment of allergic diseases and to produce adaptogenic properties....
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