Posted by admin on Sep 1, 2010 in |
The anti-allergic of an aqueous extract of the leaves of Ailanthus excelsa Roxb.(AELAq) was evaluated by using milk induced leucocytosis and eosinophilia in mice, passive paw anaphylaxis in rats models while the anticataleptic properties was evaluated by Clonidine induced catalepsy in mice mode. The extract significantly (*p<0.05, **p< 0.01) decreased the leucocytosis and eosinophilia along with passive paw anaphylaxis in the above experimental animals respectively. The extract also significantly (**p< 0.01) decreased Clonidine induced catalepsy in mice. These results suggest that aqueous extract AELAq may have the potential therapeutic value in the treatment of allergic diseases and to produce adaptogenic properties....
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Posted by admin on Sep 1, 2010 in |
The aim of the present research work is to evaluate the impact of superdisintegrants in the formulation and evaluation of rapidly disintegrating tablets. In the present study, Loratadine is the model drug. Rapidly disintegrating tablets of Loratadine was prepared by direct compression method. In this method the different excipients used were Calcium Silicate (FM1000), Pharmattose DCl-21 (anhydrous lactose), Citric acid(anhydrous), Colloidal Silica (Aerosil), Sodium stearyl fumarate, Magnesium Stearate, Crosscarmellose Sodium (AcDiSol), L-HPC( Low substituted hydroxyl propyl cellulose), Microcrystalline Cellulose (Avicel pH-200), Aspartame, Orange flavor and Strawberry flavor. The formulations containing Crosscarmellose sodium and Low substituted hydroxyl-propyl-cellulose as superdisintegrants, disintegrated faster compared to the formulation containing Microcrystalline Cellulose (Avicel pH-200). Pre compression and post compression parameters were evaluated for all eight formulations (F1-F8).Infra-Red study revealed that all polymers and excipients used were compatible with the drug. In vitro drug release showed that almost drug was release in the range of 94-97% range in 10 minutes. Depending upon cumulative drug release, in vitro disintegration time, wetting time results, one formulation F8...
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Posted by admin on Sep 1, 2010 in |
Gastric hyperacidity and gastro duodenal ulcer is a very common global problem today. Among various causes of gastric ulceration lesions caused by stress, alcohol consumption, H.pylori infection and use of NSAIDs have been shown to be mediated largely through the generation of reactive oxygen species (ROS), especially hydroxyl radical (*OH). Hyper secretion of gastric acid is a pathological condition, which occurs due to uncontrolled secretion of hydrochloric acid from the parietal cells of gastric mucosa through the proton pumping H+ K+ ATPase. The modern approach to control gastric ulcer is to inhibit gastric acid secretion, to promote gastro protection, to block apoptosis and stimulate epithelial cell-proliferation for effective healing. On contrary most of the green pharmaceuticals reduces the offensive factors and have proved to be safe, clinically effective, better patient tolerance, relatively less expensive and globally...
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Posted by admin on Sep 1, 2010 in |
Vitex negundo is an important medicinal plant with potent anti-inflammatory activity. The major constituents of this plant are flavonoids, casticin, chryso-splenol and vitexin, Chrysophenol D, nishindine and hydrocotylene. It also contains monoterpenes agnuside, eurostoside, and aucubin. These constituents contribute various pharmacological activities as anti-inflammatory, antioxidant, antinociceptive, anti-ulcer, free radicals scavenging, hepatoprotective and many more. This review discuss the investigation made by various workers related to its ethnobotanical claims, ayurvedic properties, chemical constituents, pharmacological activities ,analytical studies and other aspects considering this plant since years till date....
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Posted by admin on Sep 1, 2010 in |
Organisms containing integrated sequences of cloned DNA (transgenes), transferred using techniques of genetic engineering (to include those of gene transfer and gene substitution) are called transgenic animals. The development of transgenic animals has been part of biotechnology research which has been expanding rapidly. Transgenic animals produced with the purpose of producing better and good quality breed, increased in milk yield, as well as to produce organs to meet the demand for organ transplantation. Genetically modified animals are proving ever more vital in the development of new treatments and cures for many serious diseases. Transgenesis is a radically new technology for altering the characteristics of animals by introducing the foreign genetic material. Now a day’s numbers of methods are available to produce transgenic animals like Pronuclear micro-injection, Embryonic stem (ES) cell manipulation, Cre-lox technique, Viral vectors, Cytoplasmic injection, Primordial germ cells, Nuclear transfer and Spermatogonial manipulation among them Lentiviral vectors and Chimera generation by injecting the pluripotent cells methods are becoming important tools for transgenesis and they contributed to human...
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