Posted by admin on Aug 31, 2022 in |
A simple, one-pot, and efficient method for the synthesis of benzimidazole derivatives via the condensation of o-phenylenediamine and substituted aromatic aldehydes in the presence of Moringa oleifera (MO) seed extract acts as a biocatalyst under microwave irradiation. The method provides several advantages such as simple operation, clean reaction ways, and high to the excellent yield of product. The aqueous extract of Moringa oleifera (MO) seed as a green catalyst corresponds to an excellent yield for the synthesis of 2, 4, 5-trisubstituted imidazole derivatives under microwave irradiation method as a greener heating technique and one-pot multicomponent reaction acts as a green routine. All synthesized compounds were characterized by spectroscopic techniques such as FT-IR, 1H-NMR, 13C-NMR and LC-MS...
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Posted by admin on Aug 31, 2022 in |
The binding capacity of mucoadhesive polymers with gastric mucin prolongs the gastric residence time, increasing bioavailability. In the present research work, an attempt was made to formulate and evaluate sustain release mucoadhesive matrix tablet of Acyclovir. In the present work, an effort has been made to evaluate the effect of mucoadhesive polymers on the release characteristics of mucoadhesive matrix tablets of Acyclovir. Matrix tablets were prepared by wet granulation method using different types and levels of polymers viz. Chitosan and HPMC K4M. Tablets were evaluated for thickness, friability, hardness, uniformity of weight, the content of active ingredients, mucoadhesive strength, and in-vitro dissolution studies. The studies indicated that the drug release can be modulated by varying the concentrations of polymers. It was observed from the optimization studies that the F3 formulation has exhibited the best release profile of the drug and can sustain the drug release for 8 h with optimum mucoadhesive...
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Posted by admin on Aug 31, 2022 in |
Lavana kalpanas are pharmaceutical preparation in which the ‘Lavana’ and the selected ‘auṣadhadravyā’ are igniting together in a closed sampuṭā to obtain the drug ash as medicinal product. Nārikelā lavana, one among the lavana kalpana mentioned in Bhaiṣajyaratnāvali 30th chapter and in Rasa taraṇgiṇi14th chapter. Nārikelā lavaṇa proved to have a high amount of electrolytes like calcium and potassium, which have antacid properties. Here the common ingredient in this Kalpana is lavana, which possesses madhura–lavanarasa & śītaviryā and having pittahara property which might be the reason for the extensive use of Lavaṇa Kalpanasin pittajanyavikaras. The higher alkalinity of Nārikelā lavaṇa may also play an important role in its mode of action. Materials and Methods: Nārikelā lavana was prepared as per the reference in Rasa taraṇgiṇi, and analytical parameters were tested. The experimental study was conducted in pyloric ligated Wistar albino rats. Then the data were analyzed statistically using One Way ANOVA followed by Dunnett’s multiple “t” test as a post hoc test. Results & Discussion: The analytical parameters like...
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Posted by admin on Aug 31, 2022 in |
Background: In India, Hypertension is becoming more common and severe, and it is linked to various socio-demographic factors. Many people are ignorant of their illness’s severity and the significance of managing it due to a lack of adequate support and education. The first step in developing a preventive program for any health condition is obtaining information regarding the level of awareness. Objective: To assess the knowledge, attitude, and practice and socio-demographic factors among hypertensive patients in tertiary care teaching hospital. Materials and Methods: A prospective cross-sectional study was conducted on the sample size of 410 hypertensive patients admitted in the Medicine Unit of AH&RC during the period from February 2021 to July 2021. Socio-demographic details were collected using data collection forms. KAP scores were determined using a standardized and validated KAP questionnaire on hypertension consisting of 22 questions. Results: In our study, most of the participants were unaware of the risk factors associated with hypertension. 55% had moderate level of knowledge and same percent of participants had moderate attitude level...
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Posted by admin on Aug 31, 2022 in |
Photodermatitis had been defined within the literature after using oral dexketoprofen and different facet results as NSAIDs are also harmful for the liver. So, to triumph over such risky results, this molecule has been encapsulated with the assistance of non-ionic surfactants. Current studies supported the occasion and differentiation of transdermal proniosome-primarily based gel. The preformulation observation was completed through FTIR, and the assessment of the method through diverse parameters like PDI, zeta capacity, drug launch, encapsulation performance, and drug content material for the formulations Dt1-Dt9. The changed proniosomal gel suggests desirable balance, launch, following 0 order kinetics; most zeta strength is ± 49mv. The drug content material in the method turned inside an envisioned variety of 92-97%. The composition of the gel might be looked after as follows in relation to the viscosity of the drug: Dt3> Dt2> Dt9> Dt7> Dt4> Market gel> Dt6> Dt5> Dt1> Dt8. Span 40 & span 60 (50:50) proniosomal gel confirmed a drug launch as much as 12 h. The encapsulation performance of proniosomal...
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