Posted by admin on Aug 31, 2024 in |
Guibourtia ehie (A. Chev.) J. Leonard is a medicinal plant widely used in the Ivorian traditional medicine against stomach ulcers, sexual infections, diabetes, hypertension and microbial infections, particularly those caused by amoeba and fungi. Furthermore, this plant is widely known for its commercial interest due to economic value of its wood. Biological and phytochemical investigations also confirmed local medicinal uses of the plant and showed a various chemical composition including numerous polyphenols. In this article, we reported the results of leaves studies of Guibourtia ehie, harvested in Côte d’Ivoire, which resulted in the isolation of a new flavonol, 8-isopentenylkaempferol-7-O–β-D-(2’’’-O-galloyl) glucopyranoside (1), that we named 2’’-O-Galloyl-epimedoside C, along with two phenolic known compounds, orcinol (2) and methyl orsellinate (3). The structures of compounds where elucidated by spectroscopic data including HR-ESIMS, UV, NMR 1D (1H and 13C) and NMR 2D (COSY, HSQC and HMBC). These compounds were isolated for the first time from Guibourtia ehie (A. Chev.) J....
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Posted by admin on Aug 31, 2024 in |
Herbal medicines, with their rich history of use, often face challenges in achieving optimal effectiveness due to low absorption rates and limited bioavailability of their phytoconstituents. While these constituents are typically water-soluble, their inability to penetrate lipid membranes compromises their efficacy. To overcome these limitations, integrating herbal drugs with nanotechnology has emerged as a promising approach. Nanoparticles offer a potential solution by enhancing the absorption, permeability, and retention of herbal extracts within the body. This augmentation can lead to improved potency while minimizing the required dosage and reducing side effects. Importantly, the utilization of nanotechnology does not disrupt normal physiological processes. The primary objective of this study is to systematically explore the application of nanotechnology in crafting herbal nano formulations aimed at various pharmacological activities. Through this investigation, we aim to elucidate how nanoparticles can synergize with herbal extracts to unlock their full therapeutic potential, paving the way for enhanced herbal medicine utilization in modern healthcare...
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Posted by admin on Aug 31, 2024 in |
A fast, efficient and defined method was developed for the real-time assessment of Sitagliptin in tablet dosage form. Dissolution method was developed and carried out to predict in-vivo drug release profiles of Sitagliptin tablets. Rate and extent of dissolution of Sitagliptin tablets was studied in different dissolution medias i.e. 0.1 N HCL, pH 4.0 Acetate buffer and pH 6.8 Phosphate buffer using USP Type 1 dissolution apparatus with a RPM of 100. Ultra performance liquid chromatography was performed using BEH C18 Column (2.1x 50mm, 1.7µm). Moving phase containing Phosphate Buffer of pH 7.2, Acetonitrile and Methanol in ratio 60:20:20v/v/v was pumped through the column at 1 mL/min flow rate. Run time is 3 minutes. Injection volume is 1.7μL and column is maintained at a temperature of 25°C. Selected wavelength is 210 nm. The Dissolution method was developed and validated and was found to be Precise, Accurate, Linear in a Concentration Range of 25 % to 175 % of Test concentration. Sitagliptin retention time was found to be 1.592 minutes....
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Posted by admin on Aug 31, 2024 in |
In the pharmaceutical industry, combinatorial chemistry has emerged as a novel approach, facilitating the synthesis of multiple compounds simultaneously rather than focusing on individual compound. The quick production of the chemical means that this technology reduces the time and expense involved in drug research. In this review article, the topic of combinatorial chemistry is discussed in general terms, along with the concepts of combinatorial libraries, methodologies and applications. This technique significantly lowering the cost involved in new drug research and increases the chances of finding new lead molecules. Most commonly used combinatorial techniques are solid phase synthesis, Parallel synthesis, mixed combinatorial synthesis and solution phase synthesis. Combinatorial chemistry is useful for the efficient detection of big molecules as well as the production of tiny molecules and peptides. The aim of this project is to give a fundamental overview of combinatorial chemistry, outlining the evolution of key methods and a few...
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Posted by admin on Aug 31, 2024 in |
Medicinal plants are important for pharmacological research and drug development. Aim and Objective: The aim and objectives of present study was to evaluate the wound healing activity of seed oil of Azadirachta indica in Excision and Incision wound models in rats. Result Discussion: The study thus demonstrated the wound healing activity of Neem seed oil and found to be effective in the functional recovery of the wound. It promotes wound contraction of excision wound as compared to control...
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