Posted by admin on Aug 31, 2024 in |
A non-nucleoside reverse transcriptase inhibitor (NNRTI) is Nevirapine. Zidovudine and Lamivudine are antiretroviral medications that are members of the nucleoside analogue class. Combination of three drugs commonly used in the management of the Human Immunodeficiency Virus (HIV) infection. Nevirapine exhibits a decent initial release, while Zidovudine and Lamivudine demonstrate sustained release in the produced trilayer and bilayer tablets. The outcome demonstrates that the release profile is not affected by layer separation and is highly dependent on the drug to polymer ratio. The results show that the release can be effectively controlled for up to 12 hours using a 1:1 ratio of zidovudine and HPMC and a 1:1 ratio of lamivudine and ethyl cellulose. It is clear that formulation F1, out of all formulations, has the best sustained release, drug content, and highest regression values. Nevirapine fits best in first order release of Zidovudine in all of the F1–F6...
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Posted by admin on Aug 31, 2024 in |
“Similia Similibus Curentur,” is the therapeutic law of nature on which Homoeopathy is based. This means “Let like be treated by likes,” with a holistic and dynamic concept. As mentioned in aphorisms no. 6 and 7 (Organon of Medicine, 6th edition of Master Hahnemann) for selection the similimum, the homoeopathic physician forms a portrait of the patient after taking the history and framing “Totality of the Symptoms” with an organized placement of all the subjective and objective symptoms. The prevalence of Osteoarthritis in India is 22% to 39%. It’s a second most common Rheumatological problem facing by population with frequent joint pain, limitation in joint movement which disturbs day to day life. It was estimated as 10 th leading cause of non-fatal burden. Osteoarthritis of knee joint cause mobility impairments commonly found in aged and obese female. After Diabetes and Hypertension Osteoarthritis of the knee is a very common disease these days. Homoeopathic medicines have minute materialistic drug substance in to the potentised form and so it’s safe, and...
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Posted by admin on Aug 31, 2024 in |
The role of rhizospheric symbiotic Arbuscular Mycorrhizal (AM) fungus, non-AM fungus and bacteria in biochemical metabolites production of E. latifolia L. seedlings was analysed. The seedlings were inoculated with AM fungal strain (Glomus species), non-AM fungus (Trichoderma harzianum, Th-13) and bacteria (Pseudomonas species, Ps-1) in combined form (both, dual and triple/tripartite consortium) and analysed for their effect on the total bioactive chemical metabolites production of the target plant species. Qualitative estimation of the secondary metabolites in the said species was done and the following compounds were present viz. alkaloids, tannins, flavonoids, lignin etc. Quantitative estimation of phenolics, flavonoids, anti radical scavenging activity were observed using DPPH assay. The plant carbon and Phosphorus content were also analysed. The maximum phenolic content was obtained in the ethanolic extracts of T3 (173±0.025 mg/g) treated seedlings and the maximum flavonoid content was obtained in the ethanolic extracts of T8 (85.42±0.015 mg/g). Analyses of the free radical scavenging activity revealed that, the highest % inhibition activity was showed by T4 treatment (95.58±0.02) and the...
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Posted by admin on Aug 31, 2024 in |
An overview of the drug discovery and development process in brief helps scientists whose work could be important in deciding the process to properly design their research report for the successful translation of preclinical research to human subjects. The idea for the drug’s discovery and development may have come from a variety of sources, including the demands of the market at the time, clinical and scholarly research, the commercial environment, etc. In order to control the marketing of drugs, each pharmaceutical industry is required to abide by the laws, rules, and regulations of their respective nation. The majority of newly developed medications on the market today are synthetic. The process of developing new medications is expensive due to the significant expenses linked to research and development as well as clinical trials. Information regarding drugs, the development process, and regulating bodies in Europe, Japan, the USA, and India are provided in this...
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Posted by admin on Aug 31, 2024 in |
The Nigella sativa seeds were collected from Cuddalore and powdered thoroughly by using mortor and pestle. The Nigella sativa seeds were individually extracted with different solvents such as ethanol, methanol, acetone and water. The antibacterial activity of seed extracts were tested against the 6 ATCC pathogens such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Clostridium sporogenes, Bacillus spizizenii and Pseudomonas aeruginosa using Muller Hinton agar. The ethanol extract of Nigella sativa seed showed maximum activity against Klebsiella pneumoniae (12 mm) and Bacillus spizizenii (12 mm). The methanol extract of Nigella sativa seed exhibited minimum activity against Clostridium sporogenes (8mm), Escherichia coli (8mm), Pseudomonas aeruginosa (8mm) and highest activity against Klebsiella pneumoniae (20mm). The acetone extract of Nigella sativa seed showed highest activity against Escherichia coli (20mm). The aqueous extract of Nigella sativa seed showed maximum inhibitory activity against Klebsiella pneumoniae (23mm). Among the 4 solvent extracts, water extracts of Nigella sativa seed showed maximum inhibition. The GC-MS analysis of the Nigella sativa seed extract was carried out and it...
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