Posted by admin on Nov 30, 2025 in |
Dementia is a collection of symptoms, including memory loss and cognitive impairment, that cause neuronal disruption and lead to certain mental illnesses. The most common cause of dementia is Alzheimer’s disease (AD). Potential causes of illness extension include tau aggregation, amyloid beta build-up outside of neurons, and the formation of neurofibrillary tangles (NFTs) inside neurons. At one point in time, Alzheimer’s disease was the most common illness worldwide. The majority of research indicates that ROS (Reactive Oxygen Species) play a significant role in neurodegeneration and, eventually, Alzheimer’s disease. Amyloid-peptide increases in Alzheimer’s disease led to an increase in ROS production, which kills neurons. A transcription factor called Farnesoid X Receptor (FXR) regulates inflammation, oxidative stress (OS), and the brain’s metabolism of fats and carbohydrates. Nuclear erythroid 2 related factor 2 (Nrf2) is a transcription factor that regulates the production of many antioxidant genes and is an essential regulator of neural defence against OS. According to certain studies, Nrf2 activation can regulate the expression and activity of FXR in the...
Read More
Posted by admin on Nov 30, 2025 in |
Medicinal plants have long played a central role in traditional medicine systems for treating dermatological and metabolic disorders, including acne vulgaris, obesity, and hair fall. In this review, 70 peer-reviewed studies published between 2014 and 2025 sourced from PubMed, Scopus, Web of Science, and Google Scholar were systematically evaluated to explore the phytochemical profiles, pharmacological mechanisms, and therapeutic relevance of plant-based interventions for these conditions. This work examines the multifaceted actions of medicinal plants, focusing on antibacterial, anti-inflammatory, antioxidant, hormonal, and metabolic pathways. The review identifies key bioactive compounds such as curcumin, epigallocatechin gallate (EGCG), ginsenosides, thymoquinone, and Rosmarinic acid, which contribute to sebum regulation, adipocyte modulation, follicular stimulation, and immune response control. Notably, Azadirachta indica, Camellia sinensis, Garcinia cambogia, Panax ginseng, and Rosmarinus officinalis emerged as the most frequently studied and therapeutically promising plants. The proposed model highlights the role of phytomedicine in addressing the pathophysiology of these lifestyle-related conditions, aligning traditional knowledge with modern evidence. However, discrepancies in dosage, formulation, and extract standardization, along with a paucity...
Read More
Posted by admin on Nov 30, 2025 in |
Background: Myristicin is a naturally occurring allyl benzene primarily obtained from various plants and spices like nutmeg, fennel, parsley and carrot. Herbs and spices abundant in Myristicin are utilized in traditional medicine to manage conditions like abdominal cramps, diarrhea, rheumatism, anxiety, fever, and halitosis. Nutmeg has been utilized as a mild sedative. Myristicin produces dose-dependent neurological effects. Methods: This experimental study was carried out in the Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India. This study examined the hypnotic effects of Myristicin in rats. The method utilized to evaluate the hypnotic effect of Myristicin was pentobarbital-induced sleep potentiation. Two oral dosages of Myristicin, 10 mg/kg as well as 20 mg/kg, were administered, with propylene glycol serving as normal control. Following 60 minutes of oral dosing, pentobarbitone (30 mg/kg) was given intraperitoneally to produce sleep. Sleep latency and duration of sleep were recorded for each rat. Results: The results showed that Myristicin at 10 mg/kg dose can significantly reduce the latency of sleep in...
Read More
Posted by admin on Nov 30, 2025 in |
The present study was carried out to enhance the dissolution rate of poorly water-soluble drug Telmisartan, by solid dispersion technique using different carriers and super disintegrants by solvent evaporation method. Solid dispersions were prepared with mannitol and PEG 6000 in different ratios of 1:1, 1:3 and 1:5. In-vitro dissolution profile of solid dispersion (SD) with drug and mannitol in the ratio of 1:3 (SDM2) was found to be highest among all 12 formulations. This SD was further adsorbed with Neusilin US2 to form a ternary mixture. Crospovidone was used due to its promising role in dissolution enhancement of telmisartan based on previous studies. For optimizaton of concentration of Neusilin US2 and crospovidone in solid dispersion, Central Composite Design was applied for two factors at two level which gave 13 formulations. Tablets were prepared and evaluated for physiochemical properties. Reponse surface plot and contour plot were drawn, and an optimum formulation was selected. This formulation contained 40 mg of Neusilin and 14 mg Crospovidone (CCDF4). The in-vitro dissolution studies of...
Read More
Posted by admin on Nov 30, 2025 in |
Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels, with type II diabetes mellitus being the most prevalent form, primarily resulting from insulin resistance and/or insufficient insulin secretion. Mucoadhesive buccal patches, which are designed to adhere to the buccal mucosa for systemic effectiveness, offer a more effective option for oral administration because they bypass the first pass metabolism. Linagliptin, a dipeptidyl peptidase-4 (DPP-4) Inhibitor, is commonly used for the management of type II diabetes but suffers from limitations related to oral bioavailability and patient adherence. The present study aims to formulate and evaluate a Mucoadhesive buccal patch of linagliptin to provide sustained drug release and improve therapeutic effects. The primary objective Includes assessing the Mucoadhesive strength to ensure prolonged adhesion to the buccal mucosa, evaluating the formulation for pharmaceutical Suitability, and creating an ideal patch with desired physicochemical properties. The buccal patches were successfully developed with polyvinylpyrrolidone K30 (PVP K30) and hydroxypropyl methylcellulose (HPMC) as polymers using the solvent casting method, and the selected polymers...
Read More
