Posted by admin on May 31, 2025 in |
Background: Chronic Kidney Disease (CKD) is a progressive condition associated with high rates of morbidity and mortality, often leading to end-stage renal disease (ESRD), cardiovascular events, and a reduced quality of life. Effective medication adherence is critical for preventing adverse outcomes and improving long-term survival. Objective: The primary objective of this study was to assess the effectiveness of a pharmacist-led patient education program in improving medication adherence and enhancing medication knowledge in hemodialysis patients. Secondary objectives included examining the relationship between adherence and demographic factors. Methods: A prospective interventional study was conducted on 109 hemodialysis patients. Medication adherence was assessed using the General Medication Adherence Scale (GMAS), and patient medication knowledge was evaluated through the Patient Medication Knowledge Assessment (PMKA). Statistical analysis was performed to evaluate the significance of changes in adherence and knowledge. Results: Among the 109 participants, the pharmacist-led intervention resulted in a highly significant improvement in medication adherence, as measured by GMAS (p < 0.001). Patient knowledge, assessed through PMKA, also showed a statistically significant increase...
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Posted by admin on May 31, 2025 in |
Hernia repair is one of the most common surgeries, with recent advancements in mesh technology and surgical techniques significantly improving outcomes. Mesh implants are the standard for reinforcing abdominal walls, reducing recurrence rates compared to traditional sutures. However, complications like chronic pain, infection, and adhesions have driven innovations in mesh development. Modern synthetic meshes are designed to enhance biocompatibility, featuring lightweight, macro-porous structures to promote tissue integration while minimizing complications. Biologic meshes, derived from human or animal tissue, support tissue regeneration and gradually degrade, reducing long-term foreign body reactions. Hybrid meshes combine the durability of synthetics with the regenerative qualities of biologics, offering superior performance in complex repairs. Tailored approaches, including 3D-printed and custom-made meshes, are gaining popularity for their ability to match individual anatomy, minimizing complications such as displacement. Future developments focus on anti-adhesion coatings and bioactive meshes capable of releasing antimicrobial agents to address postoperative issues like adhesions and infections. Despite these advancements, challenges remain in selecting the optimal mesh type and technique for each patient. Financial...
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Posted by admin on May 31, 2025 in |
Hypertension (HTN), a major global health concern and the primary cause of cardiovascular disease (CVD) death is expected to impact 29% of all adults by 2025. Hypertension (HTN) is a multifactorial condition, arising from the complex interaction of hereditary, environmental, and physiological variables that contribute to elevated systolic and diastolic blood pressure. It is frequently caused by dysregulation of blood pressure control mechanisms, such as over activity of the renin-angiotensin system and increased sympathetic nervous system activity. Traditional hypertension therapies, such as ACE inhibitors and beta-blockers, have drawbacks, including low solubility and absorption. As a result, researchers are increasingly focusing on novel treatment approaches, such as medicinal plants and nanotechnology. Herbal plants such as Ashwagandha, Cat’s Claw, Ginger, Ginseng, Murungai, and Touch-Me-Not belonging to different families are renowned for pharmacological activities and have shown potential medicines antihypertensive properties, which are often attributed to their bioactive constituents. Recent breakthroughs in nanotechnology have permitted the manufacture of nanoparticles derived from these plants, improving their stability, bioavailability, and potency. These plant-mediated nanoparticles...
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Posted by admin on May 31, 2025 in |
Perimenopause is a transitional stage in a woman’s life, typically occurring in her 40s, leading up to menopause. During this time, hormonal changes, particularly a decline in estrogen levels, can have a significant impact on bone health. Calcium citrate is a commonly used calcium supplement that is known to promote bone health. Isoflavones are a type of phytoestrogen found in plants, particularlyin soybeans and soy products. The study aimed to compare the effects of calcium citrate and isoflavones on BMD in perimenopausal women with low BMD. 60 perimenopausal women with low BMD, aged 40-55 years, who were divided into two groups: Group A received Calcium citrate supplementation, while Group B received Calcium citrate+Isoflavones supplementation. BMD was measured at baseline and after 3 months using Dual-Energy X-ray Absorptiometry (DEXA). After 3 months, both groups showed improvements in BMD compared to baseline (p <0.05). The increase in BMD was greater in Group B (Calcium citrate + Isoflavones) compared to Group A (Calcium citrate) (p<0.05) Results revealed that the combination of calcium...
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Posted by admin on May 31, 2025 in |
The quest for natural immunomodulators has led to the exploration of traditional Indian herbs, renowned for their immune-boosting properties. In this study the goal was to create and assess a polyherbal formulation that contained extracts of all herbs. A polyherbal tablet was formulated using a combination of Giloy (Tinospora cordifolia), Amla (Emblica officinalis Gaertn), and Tulsi (Ocimum sanctum) in a specific ratio. Giloy (Tinospora cordifolia) is a plant that contains antioxidants. It also has anti-inflammatory, antimicrobial, and antidiabetic properties. Tulsi (Ocimum sanctum) contains antioxidant, antimicrobial, anti-inflammatory, anti-diabetic, Immunomodulatory, anti-carcenogenic properties. Amla, also known as Indian gooseberry, has many properties, including antioxidant, anti-inflammatory, and hepatoprotective. The tablet’s physicochemical properties, such as hardness, friability, and disintegration time, were evaluated. The formulated tablet exhibited satisfactory physicochemical properties. The polyherbal tablet containing Giloy, Amla, and Tulsi demonstrated potent immunomodulatory activity, validating the traditional use of these herbs in Ayurvedic medicine. This formulation offers a promising natural adjunct to conventional immunotherapies, warranting further clinical investigation. Polyherbal formulations have emerged as a promising strategy to...
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