Posted by admin on Feb 28, 2025 in |
Today, obesity has become a global pandemic affecting billions of people worldwide. It is associated with increased risks of various diseases, including cardiovascular and musculoskeletal diseases, psychiatric disorders, cancer, and diabetes, making it a significant public health issue. Obesity has also been linked to an elevated risk of metabolic diseases and changes in brain structure and function. The body mass index (BMI) is widely used to determine excessive weight in relation to height and age. However, BMI may not be accurate for everyone, and BMI z-scores are employed when analyzing data on children and adolescents. The accumulation of excess body fat, which contributes to obesity, is attributed to an imbalance between energy intake and expenditure, controlled by the brain’s central nervous system. Disturbances in the brain circuits that regulate energy balance can impact body weight and adiposity, often involving changes in neurotransmission, which may be addressed with CNS-targeting drugs. The pathogenesis of obesity is characterized by a chronic energy imbalance between excessive calorie intake and inadequate calorie expenditure, primarily...
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Posted by admin on Feb 28, 2025 in |
Discovering Novel MAO-B inhibitors is promising therapeutic strategy for Parkinson’s disease. The pharmacological effects of MAO-B inhibitor showed significant neuro-protection and improved motor function and reduced oxidative stress marker. In-silico molecular docking simulation to investigate the interaction between target protein (MAO-B Inhibitors) and revealing promising hits with high binding affinity and favorable interactions. Molecular docking and binding affinity were analyzed between protein MAO-B inhibitor with selected bioactive compounds and Synthetic drugs in order to find the most potential inhibitor against the target. Thus, the objective of this research can provide an insight comparision based prediction towards some bioactive compounds in Genus momordica species (folic acid, momordicin, Balsaminol-A, Karavilagenin-C, Beta carotene) and few synthetic drugs (Opicapone, Apomorphine, Selegiline, Rasagiline, Ladostigil Zonisamide, Safinamide, NSAID, RG-2833 (gene therapy drug) against MOA-B Inhibitors performed using Pubchem, ProteinDataBank, Biovia discovery studio and PyRx. This research focuses on docking between the potential bioactive compounds shows strong affinity towards the targeted MOA-B inhibitor protein to treat parkinson’s diseases compared to synthetic drugs. This study shows the...
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Posted by admin on Feb 28, 2025 in |
The development of fast-dissolving oral thin films has recently followed the progression of dosage forms from straightforward ordinary tablets and capsules to modified release tablets and capsules, oral disintegrating tablets, and wafers. A hydrophilic polymer used in fast- dissolving oral thin films quickly hydrates or adheres when applied on the tongue or in buccal cavity. These films melt or disintegrate in a matter of seconds, releasing the active ingredient without need for drinking or chewing. A drug-containing thin film with surface area of 5 to 20 cm2 is called an oral dissolving film. The maximum single dose of the drugs that can be loaded is 30 mg. As opposed to tablets, several pharmaceutical companies are now producing oral thin films that dissolve quickly. Films combine the benefits of liquid dosage forms with those of tablets, such as exact dose and simple administration (easy swallowing, rapid bioavailability). At the same time, it gives a general overview of crucial formulation design factors that have an impact on thin films, such as...
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Posted by admin on Feb 28, 2025 in |
Within the Magnoliopsida class, Pyrus pashia is widely found throughout the Himalayan areas. P. pashia is a member of the Rosaceae family of medicinal plants. It’s commonly called a wild pear. The plant has a range of nutritional and medicinal uses. In ethnomedicine, it is widely utilized as a hepatoprotective, inflammatory, antibacterial, antifungal, disinfectant, antioxidant, antimicrobial, and antidepressant to treat a wide range of illnesses. The genus P. pashia comprises approximately 38 species globally and contains approximately 160 phytochemical compounds, including primary and secondary metabolites such as alkaloids, glycosides, flavonoids, steroids, saponins, and tannins. Additionally, it contains useful polyphenolic therapeutic constituents like arbutin, flavan-3-ols, and chlorogenic acids. The phytochemistry, pharmacological activity, ethnomedicinal applications, and toxicological profile of P. pashia are all thoroughly updated in this review. This plant’s scientific understanding as well as its potential for use in pharmaceutical research in the future, are critically...
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Posted by admin on Feb 28, 2025 in |
Giving birth is the most physically exhausting experience for a woman’s body. Tribal societies use medicinal plants and nutrient-dense foods as natural remedies to boost vitality, facilitate healing, and increase milk supply after delivery of women. The present study was carried outinthetribal-dominated areas of southern Rajasthan, including Banswara, Chittorgarh, Dungarpur, Pratapgarh, Udaipur, and certain parts of Sirohi District. During the study, group discussions and interviews were done with the active participation of local women, health practitioners, and elders known as dais or gunis, who are experts in delivering traditional health care services to lactating mothers in the research area. In the present study, 11 plant species from 9 families were reported as being used to boost milk production and support postpartum recovery by tribal women. The study revealed significant and vital information on the diversity of medicinal plants used by various traditional practitioners in postnatal care, which can be further integrated into the modern healthcare system to improve the health status of lactating women...
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