Posted by admin on Feb 28, 2025 in |
Objectives: Transitioning from a family-centred clinic to a patient-centred clinic is an inevitable and fragile process through which patients and caregivers have to go through. This study aimed to identify transition issues and assess the role of pharmacists during this phase. Method: A mixed-method approach combining qualitative and quantitative analysis was used to identify factors that may contribute to uncontrolled diabetes during the transition period. Due to the challenges posed by the COVID-19 pandemic, three online questionnaires were developed, reviewed, and distributed via social media to patients, caregivers, and healthcare professionals. Key Findings: Concerns were raised about being under the care of a new doctor and not being provided enough support and care during the transition. Participants noticed a shift towards self-management as they moved between clinics. Furthermore, there was strong support for the involvement of pharmacists in the transition process, with participants agreeing that pharmacists could help reduce medication errors. Conclusion: A well-structured transition plan can ease the shift from paediatric to adult care. A multidisciplinary approach, involving...
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Posted by admin on Feb 28, 2025 in |
An ayurvedic nutritional tonic, i.e., Dashmularishta, is made up of ten different plants that support gut health and restore appetite by relieving indigestion, bloating, etc. U. picta is one of the important medicinal plant used in this formulation. Due to ever increasing demand U. picta is now in the status of endangered. As a result, many of its similar species are being used as its adulterant in the formulation. A comparative study has been performed on U. picta and its adulterant species (D. gangaticum, D. puchellum, D. velutinum, D. longipes, and L. reticulate) for their effectiveness against multidrug-resistant bacteria. The plant extracts from these plants were screened against ten different clinical isolates of multidrug-resistant bacteria. U. picta, D. gangaticum, and D. puchellum exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli. However, U. picta presented minimum inhibitory concentrations (MICs) of 25 mg/ml and 12.5 mg/ml against Staphylococcus aureus and Escherichia coli, respectively. In contrast, D. gangaticum presented MICs of 12.5 mg/ml and 50 mg/ml against Staphylococcus aureus and Escherichia...
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Posted by admin on Feb 28, 2025 in |
The phenomenon known as mucoadhesion is characterized by interfacial molecular attractive forces between a natural or synthetic polymer and the surface of a biological membrane. This allows the polymer to stick to the membrane’s surface for a prolonged period of time. The idea of mucoadhesion has garnered significant attention in many pharmaceutics sectors during the past forty years. The mucoadhesive buccal drug delivery system has numerous benefits that make it a unique drug delivery method for both local and systemic administration of different medications. The primary benefit of using this route for medication administration is that it avoids the initial metabolic stage of many methods circumvents the first pass metabolism of a number of medications that are susceptible to their first pass metabolism in the liver. Mucoadhesive drug delivery system contacts with mucus layer and generally increases the retention time of the dosage form at the specific site of absorption. The structural characteristics of the mucosa, the mechanism of mucoadhesion, various theories of mucoadhesion, are briefly discussed in this...
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Posted by admin on Feb 28, 2025 in |
Background: Depression is a major public health disorder, with antidepressants like Selective Serotonin Reuptake Inhibitors (SSRI) and Serotonin and Norepinephrine Reuptake Inhibitors (SNRI) improving outcomes for Major Depressive Disorder (MDD) patients. However, determining which category is superior remains unclear. This study aimed to compare the efficacy and safety profile of Escitalopram (SSRI) versus Venlafaxine/Desvenlafaxine (SNRIs) in patients of depression. Material and Methods: An observational cross-sectional study was conducted at Outpatient Department (OPD) of Psychiatry; in 120 eligible MDD patients, already taking tablet escitalopram (10-20 mg/day) or venlafaxine (75 – 375 mg/day)/desvenlafaxine (25-100 mg/day) at least for 1 month duration. Therapeutic Efficacy was assessed by HAM-D (Hamilton rating scale for Depression) and CGI (Clinical Global Impressions) Scale. Safety profile was evaluated with the help of ASEC (Anti-Depressant Side Effect Checklist) by assessing the adverse effects experienced by patients. Independent t-test and chi square test were used to analyse quantitative and qualitative variables respectively. Results: Mean (±SD) scores of HAM-D and CGI scales in escitalopram group were significantly higher than venlafaxine/...
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Posted by admin on Feb 28, 2025 in |
The physiological and biochemical changes in plants are affected by water deficiency caused by polyethylene glycol (PEG). It is a synthetic, water-soluble polymer and induces water deficit conditions. Its application is useful to induce drought stress in different plant varieties. The purpose of this study is to understand the effects of different concentrations of polyethylene glycol on the antioxidant system of Vigna radiata seeds. The polyphenol oxidase, peroxidase and proline content increased with the increment of water stress induced by polyethylene glycol. Enhanced activities of antioxidants could either be a response to the cellular damage induced by the stressors or a mechanism towards the damages. Obtained results of this research indicated that the activities of PPO, POD and proline had significant increase in the plants under the treatment of...
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