Posted by admin on Feb 28, 2025 in |
Fungal exudate is the phenomenon that involves the exudation of water and metabolites produced by fungal cells, Fungal exudates are rich sources of bioactive secondary metabolites with potential applications. Exudates are a prevalent phenomenon in the fungal domain, influenced by various factors, such as the composition of the growth medium and incubation temperature. Filamentous fungi, renowned for their extensive metabolic capabilities, release exudates that act as reservoirs for a wide range of bioactive compounds. These exudates, often underexplored, contain diverse secondary metabolites and proteins with significant biological activities. From Centella asiatica, 30 fungal isolates were obtained, of which 12 were analyzed based on morphological and cultural characteristics. Among these, Talaromyces verruculosus and Penicillium chrysogenum exhibited exudate production. SEM analysis highlighted the structural morphology of the fungi, while ATR- FTIR revealed the presence of diverse functional groups, indicative of a complex chemical composition, Exudates from T. verruculosus exhibited hydroxyl (-OH) stretch, isothiocyanate (-NCS), conjugated alkene, allenes, amines, and aliphatic iodo compounds. In contrast, P. chrysogenum exudates contained secondary amines, carbodiimides,...
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Posted by admin on Feb 28, 2025 in |
The objective of this investigation was to synthesize spirothiazolidinone-chalcone derivatives and evaluate them for anti-inflammatory action. Five 4-substituted benzaldehydes were utilized for the aldol condensation leading to chalcones of spirothiazolidinone. The compounds were obtained in yield of 64-72% and displayed varying solubility with all compounds soluble in chloroform and DMSO. The NMR spectra revealed protons of amine, imine, hydroxy and aromatic groups. The presence of the molecular ion peak of the isotopic peak was found in the mass spectra of the compounds confirming the formation of the compounds. The anti-inflammatory activity was determined using the albumin denaturation method and antiprotease method. All the compounds exhibited dose dependent inhibition of albumin denaturation with 7d having the highest capacity to cause the inhibition (61.56 ± 1.033 %) at the concentration of 500µg/mL. The antiprotease action was also dose dependent and 7d at 500µg/mL was able to inhibit (46.32±3.011 %) of protease activity. The type of substitution on the chalcone phenyl ring played a vital role in the activity of the compounds....
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Posted by admin on Feb 28, 2025 in |
Malnutrition continues to be a significant public health concern, affecting the survival, growth, and well-being of both current and future generations, especially in developing nations such as India. This study examines the intricate characteristics of malnutrition, including insufficient and excessive nutrition, with a major emphasis on protein-energy malnutrition (PEM) in children, the high occurrence of stunting, wasting, and underweight conditions in children, based on data from the National Family Health Survey (NFHS-5) and multiple studies conducted in Jaipur. It emphasizes the notable gender discrepancies and socio-economic factors contributing to these conditions. Ayurveda emphasizes the significance of maintaining a well-balanced diet (Aahara) and recognizes the influence of Vata dosha in disturbing the process of digestion and absorption of nutrients, resulting in ailments like Karshya, Balashosha, and associated disorders. Ayurvedic therapies prioritize dietary alterations, herbal supplementation, and lifestyle adjustments to restore physiological equilibrium and enhance overall well-being. This article suggests incorporating Ayurvedic concepts into current government nutrition initiatives, such as POSHAN Abhiyaan and Pradhan Mantri Matru Vandana Yojana (PMMVY). Concrete suggestions encompass...
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Posted by admin on Feb 28, 2025 in |
The delineation, characterization, and fingerprint profiling of metabolites derived from Siddha formulations are pivotal in advancing drug development and substantiating time-honored evidence-based medicinal practices. This study employs an untargeted metabolomics approach utilizing High Resolution Liquid Chromatography Mass Spectrometry (HR-LCMS) to investigate the Siddha herbal formulation ‘Vaasathi kashayam,’ as documented in the classical text ‘Agasthiyar 2000,’ specifically indicated for Raththa kothippu noi (systemic hypertension). Among the 32 categories of internal medicines, Kashayam or Kudineer is a decoction characterized by a limited shelf life of merely three hours. Vaasathi kashayam is freshly prepared from equal proportions of Justicia adhatoda L. (Acanthaceae) leaves and Vitis vinifera (Vitaceae) dried fruits. Compounds isolated via Q-TOF liquid chromatography were analyzed through mass spectrometry, with their mass values confirmed through database searches. Approximately 20 metabolites were identified in both solvent A (0.1% formic acid aqueous solution) and solvent B (acetonitrile), including notable compounds such as Peganine (a vasicine-quinazoline alkaloid), Jatrophone (a macrocyclic diterpenoid), Kuwanon Z (a flavan), and Isoacteoside (a hydrocinnamic acid). The classification of these...
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Posted by admin on Feb 28, 2025 in |
Globally, traditional herbal medicine has played a crucial role in primary healthcare. The recent surge in research on herbal medicine systems has led to a higher demand for medicinal plants in the global phytomedicine market. However, this increased demand also raises the risk of adulteration of raw drugs, posing potential threats to consumer health and safety. Thus, there is a pressing need for proper identification and pharmacognostical evaluation of crude medicinal plants. Addressing these concerns, a study was conducted on Stevia rebaudiana Bert. Linn. to assess its pharmacognostical features for accurate identification, focusing on various morphological and microscopic characteristics of the leaves. Parameters such as Stomatal index, Stomatal number, Palisade ratio, vein-islet number, and vein termination number were also analysed. This study holds significance in pharmacognostical identification, as its findings may contribute substantially to ensuring the integrity and authenticity of Stevia rebaudiana leaves in...
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