Posted by admin on Feb 1, 2013 in |
Recently, controlled and sustained drug delivery has become the standard in modern pharmaceutical design and an intensive research have been undertaken in achieving much better drug product effectiveness, reliability and safety. This interest has been sparked by the advantages shown by in situ gelforming drug delivery systems such as ease of administration and reduced frequency of administration, improved patient compliance and comfort. The formation of gels depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation, from which the drug gets released in a sustained and controlled manner. Various biodegradable polymers that are used for the formulation of in situ gels include gellan gum, alginic acid, xyloglucan, pectin, chitosan, poly(DL lactic acid), poly(DL-lactide-co-glycolide) and poly-caprolactone. Mainly in situ gels are administered by oral, ocular, rectal, vaginal, injectable and intraperitoneal routes. In situ gel forming injectable drug delivery system is the ability to inject a drug incorporated into a polymer to a localized site and have the polymer form a semi-solid gel drug depot has...
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Posted by admin on Feb 1, 2013 in |
Ayurveda– The science of life is known to the mankind since time immemorial. It prolongs life span, maintains positive health and cures diseases. Due to its high effectiveness, popularity and the socio-economic status it was recognized as an independent branch of learning and has been known as “Rasa Shastra” and “Rasa chikitsa” in the field of Ayurveda. After the development of rasa Shastra it was made possible for the minerals and metals, precious and semiprecious stones to pass through various pharmaceutical processes like shodhana, Marana etc. for several times so as to convert these in to a form or compound which may suit to the human body and could be observed and assimilated easily into the system without exhibiting any toxic symptom. There are two objectives to purify a natural herb. There are two objectives of purification. First is to remove the external and internal impurities. The second reason is to increase the medicinal value. The shodhana processes of guggul can be done by general purification and specific purification....
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Posted by admin on Feb 1, 2013 in |
The study is aimed at development of physicochemical parameters and to investigate the active principle present in Tridax procumbens Linn. Tridax procumbens Linn. (Asteraceae) commonly known as Coat Buttons is an important plant used against various disorders in indigenous system of medicine such as Wound-Healing, Hepatoprotective, Anti-Inflammatory, Anti-diabetic and Immunomodulatory activities. However its functional properties and the underlying mechanism of action have not been clearly defined, the present study was undertaken to evaluate anthelmintic activity of methanol extract of leaves of Tridax procumbens L. against Pheretima posthuma (earthworm). Various concentrations (10, 20, 30mg/ml) of methanolic extract were evaluated in the bioassay involving determination of time of paralysis (P) and time of death (D) of the worms. Albendazole was used as standard anthelmintic drug and distilled water was used as control. The results of present study indicated that the methanolic extract of leaves of Tridax procumbens showes significantly dose depending pharmacological...
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Posted by admin on Feb 1, 2013 in |
The importance of medicinal plant has been emphasized from time to time. It is believed that the drug of natural origin shall play an important role in health care particularly in rural areas of India. Ziziphus mauritiana belongs to family Rhamnaceae and commonly known as Indian jujube or ber .The leaves are alternate and elliptic. Flowers are small and bisexual .The leaves are about 2.5 – 3.2 cm long. Commercially it is cultivated in China & India. Ziziphus mauritiana is small to medium sized spiny tree. Ziziphus mauritiana contains fructose, galactose, malonic acid, malic acid, p-hydroxybenzoic acid, caffeic acid, ferulic acid and vanillic acid .The antioxidant activities of the plant extract and pure compounds were assessed by Reduction of NBT (Nitro Blue Terazolium) and Nitric Oxide Radical Inhibition activity method. The five successive extract (benzene, petroleum ether, chloroform, methanol and aqueous extract) of Ziziphus mauritiana Leaves and one standard (Ascorbic acid) were tested for in-vitro antioxidant activity. The result was expressed as IC50 values and percentage inhibition at different...
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Posted by admin on Feb 1, 2013 in |
Foods and nutrients play a vital role in normal functioning of the body. They are helpful in maintaining the health of the individual and in reducing the risk of various diseases. Worldwide acceptance of this fact formed a recognition link between “nutrition” and “health” and the concept of “nutraceuticals” has evolved. More than any other disease, the etiology of cardiovascular disease reveals many risk factors that are amenable to nutraceutical intervention. The scientific literature shows that there are several bioactive ingredients that are present in small amounts in plants that can affect mammalian biological processes relevant to cardiovascular disease and other common human diseases. The ability of bioactive ingredients to positively influence cardiovascular risk factors should be recognized as an enormous opportunity in the treatment of a highly prevalent disease. Nutraceuticals hold promise in clinical therapy as they have the potential to significantly reduce the risk of side effects associated with drugs and pills along with reducing the global health care cost. Common ingredients that have been studied include...
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