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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 5 (2014) - Issue 5, May

Review Articles

 
Title
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1.

ADVANCEMENT IN ENDOPHYTIC MICROBES FROM MEDICINAL PLANTS

This overview firstly highlights biology of endophytic microbes from medicinal plants as well as their chemistry with emphasis on the important merging of microbiology and natural products chemistry and its role in improving our current knowledge of endophytic associations in medicinal plants. Secondary metabolites of medicinal plants-derived endophytes reported in recent years are grouped accordi...

Huawei Zhang*, Chen Ying , and Xuelian Bai

Associate professor (Biopharmaceutics), School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1589-1600

1589-1600

2888

2474

2.

ACHYRANTHES ASPERA: A POTENT IMMUNOSTIMULATING PLANT FOR TRADITIONAL MEDICINE

Achyranthes aspera L. (family: Amaranthaceae), an erect and much branched diffuse herb is a medicinal plant, frequently found in tropical and warmer regions as weed. The plants are reported to contain following major classes of compounds: fatty acids, a number of oleonic acid, bisdesmosidic, triterpenoid based saponins, ecdysterone, n-hexacos-14- enoic, oleanolic acid, triacontanol, spinasterol,di...

Praveen Kumar Srivastava

Department of Zoology, University of Delhi, Delhi, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1601-11

1601-1611

3850

3150

3.

A REVIEW ON ANTI-VENOM ACTIVITY OF SOME MEDICINAL PLANTS

In almost every part of the world, where venomous snake occur, numerous plant species are used as folk medicine to treat snake bite. The mortality associated with snake bites is a serious public health problem as the estimated death incidence per year is about 1,25,000 globally. In India, about 35,000 to 50,000 people reportedly die of snake bite; although, unreported cases may be even more in rur...

Ankur Das Barma*, Jyochhana Priya Mohanty and Nihar Ranjan Bhuyan

Department of Pharmacognosy, Himalayan Pharmacy Institute, Majhitar-737136, East Sikkim, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1612-15

1612-1615

5356

2007

5.

ANTIEMETIC DRUGS AS A NASAL DRUG DELIVERY – A REVIEW

Antiemetic drugs are used in the treatment of nausea and emesis. Development of novel delivery systems for antiemetic drugs, as an alternative to conventional preparations, is essential in terms of good patient compliance and improving bioavailability. The nasal route offers exclusive superiorities, such as rapid and high drug absorption, and high patient compliance. Consequently, a considerable a...

J. Joysa Ruby* and V.P. Pandey

Department of Pharmacy, Annamalai University, Annamalai Nagar-608002, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1624-29

1624-1629

2618

1920

6.

A COMPREHENSIVE REVIEW: BERGENIA LIGULATA WALL – A CONTROVERSIAL CLINICAL CANDIDATE

Bergenia ligulata Wall is considered amongst the high valued medicinal herbs and one of the important examples of controversial drugs which is popularly known as ‘Paashanbheda’ (meaning ‘to dissolve the stone’) in Indian systems of medicine. The phytochemical studies have shown the presence of many secondary metabolites belonging to coumarins, flavonoids, benzenoids, lactone, carbohydrate,...

S.S. Gurav* and N.S. Gurav

Head of Department, Govt. College of Pharmacy, Karad, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1630-42

1630-1642

3628

4722

7.

RECENT TRENDS IN PROBIOTICS AND HEALTH MANAGEMENT: A REVIEW

Probiotics are defined as “Live microorganisms” which when administered in sufficient amounts confer a health benefit to the host. They are consumed as microbial food supplements.The mechanism of action of probiotics is associated with their ability to enhance immune response, compete with pathogenic microbes for adhesion sites, to antagonize these pathogens and production of antimicrobial sub...

Bharti Mahajan and Vinod Singh*

Department of Microbiology, Barkatullah University, Bhopal, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1643-52

1643-1652

1704

983

8.

EMULGEL: AN EMERGENT TOOL IN TOPICAL DRUG DELIVERY

In comparison among the other groups of semisolid preparations, the use of gels has been emerged both in cosmetics and in pharmaceutical preparations because of its unique array of features. Despite of providing several benefits the category gel faces limitations in delivering hydrophobic drug molecules via skin. So in order to cover up this lacking a recent emulsion based approach is bein...

Anu Hardenia*, Sonali Jayronia and Sanjay Jain

Smriti College of Pharmaceutical Education, 4/1 Pipliya Kumar Kakad, Maya Khedi Road, Indore 452010, (MP), India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1653-60

1653-1660

6055

11133

9.

CONTROLLED DRUG RELEASE FOR POORLY WATER SOLUBLE DRUGS- A ROLE OF POLYMERIC NANOPARTICLES

In the treatment of health related dysfunctions, it is desirable that the drug reaches its site of action at a particular concentration and that this therapeutic dose range remains constant over a sufficiently long period of time to alter the process. Delivery of hydrophobic molecules and proteins has been an issue to poor bioavailability following administration. Thus, micelle carrier systems are...

RituTiwari*, Ram Prakash Aharwal, Sandeep Shukla and Archna Pandey

Department of Chemistry, Dr. H.S. Gour Central University, Sagar, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1661-70

1661-1670

2543

771

Research Articles

 
Title
Views
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10.

THE EFFECT OF DI-BUTYL PHTHALATES (DBP) AND DI (2-ETHYLHEXYL) PHTHALATES (DEHP) ON FEMALE RATS FERTILITY

Phthalate esters are industrial chemicals widely used in cosmetics, plastics bottles and medical devices, and the risk of exposure to phthalates is on the increase.  In recent years, many studies have been carried out on the possible health hazards of phthalates, including the effect on reproduction. In this studyrats were injected twice weekly with Di-butyl Phthalates (DBP) or Di (2-Ethylhexyl) ...

S. Abdul-Ghani , R. Abdul-Ghani*, M. Qazzaz and Z. Abdeen

Biochemistry Department, Faculty of Medicine, Al-Quds, University East Jerusalem, West Bank- P.O.Box2003, Palestine

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1671-81

1671-1681

1631

602

11.

PHYTOTHERAPY AS NEW APPROACH TO TREAT SCORPION ENVENOMATION: EXPERIMENTAL STUDY

Citrullus colocynthis is a wild common plant in arid and semi arid areas of Algeria which are characterized by high incidence of scorpion envenomation. It is used in Algeria to treat many diseases. In order to optimize and develop new therapeutic strategies for scorpion envenoming, a phytotherapeutic approach has been investigated. Pharmacological properties of Citrullus colocynthis were evaluated...

Laraba-Djebari Fatima* and Kabrine Mohamed

USTHB, Faculty of Biological Sciences, Laboratory of Cellular and Molecular Biology, BP 32 El Alia, Bab Ezzouar, Algiers, Algeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1682-92

1682-1692

1634

900

12.

PREPARATION AND CHARACTERIZATION OF SOLID LIPID NANOPARTICLES THROUGH RAPID EXPANSION OF SUPERCRITICAL SOLUTION

Rapid expansion of supercritical solution (RESS) has provided a promising alternative to produce ultrafine particles of heat-sensitive materials. Stearic acid is a good lipid for development of solid lipid nanoparticles (SLNs) in drug delivery systems. Therefore, currently, much research on the micronization of stearic acid is going on. In this study, formation of submicron stearic acid was report...

Zahra Akbari*,MasoudAmanlou, JavadKarimi-Sabet, AbolfazlGolestaniand MojtabaShariatyNiassar

School of Chemical Engineering, College of engineering, University of Tehran, Tehran, Iran

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1693-04

1693-1704

1696

900

13.

SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL ACTIVITIES OF PYRIMIDINE DERIVATIVES CONTAINING 2-PYRAZOLIN-5-ONE

A new series of thiazolo [3',2';1,2] pyrimido [5,4,e] pyrimidines and thiazolo [3',2';1,2] [1,2,4] triazolo [3'',4''-c]pyrimido [5,4-e] pyrimidines linked to 2-pyrazolin-5-one moiety were prepared by derivatization of the hydrazine functionality of the heterocyclic hydrazine with various reagents. The newly synthesized compounds were characterized by elemental analyses and spectroscopic techniques...

Mohamed Salah K. Youssef* and Ahmed Abdou O. Abeed

Department of Chemistry, Faculty of Science, Assiut University, Assiut, 71516, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1705-20

1705-1720

1604

0

14.

PHYSICAL-CHEMICAL CHARACTERIZATION, ANATOMICAL AND SEASONAL EVALUATION OF THUJA OCCIDENTALIS L. (CUPRESSACEAE)

Thuja occidentalis L. is a plant widely used therapeutically. Having seen the necessity to standardize the vegetal drug and to evaluate the interference of certain environmental and seasonal factors on the synthesis of metabolites, notably flavonoids, this work considered anatomical and physical-chemical characterization assays for the aforesaid vegetal drug, in addition to phytochemical prospecti...

C.B.M. Figueirêdo , L.D.S. Alves , C.C.A.R. Silva , P.A. Ferreira , G.S. Marques , A.S.C.O. Santana , K.P. Randau , R.M.M. Pimentel , R.M.F. Silva and P.J. Rolim-Neto*

Department of Pharmaceutical Sciences, Federal University of Pernambuco, Brazil.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1721-31

1721-1731

1789

939

15.

IN VITRO SUSCEPTIBILITY OF PLASMODIUM FALCIPARUM TO LUMEFANTRINE AND ANALYSIS OF POLYMOPHYSIMS IN PFMDR-1 GENE ISOLATES FROM ABIDJAN (CÔTE D’IVOIRE)

Context: Malaria endemic disease remains the most common tropical parasitic disease in the world. According to the World Health Organization (WHO), malaria is the first endemic disease of which humanity is paying a heavy price. Malaria is a major public health problem in Côte d'Ivoire. Objective: To evaluate the in vitro chemosensitivity to Lumefantrine (LUM) and analyze Pfmdr-1gene polymorphism ...

Trebissou Jonhson Noel David* , Yavo William , Tano Konan Dominique , N’cho Monsan , Yapi Houphouet Felix , Djaman Allico Joseph

Pharmacodynamics Biochemical Laboratory, UFR Biosciences, Felix Houphouet Boigny, University, PO BOX, 582 Abidjan 22- Côte d’Ivoire

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1732-38

1732-1738

1612

461

16.

PHYTOCHEMICAL ANALYSIS, TOXICITY AND ANTIBACTERIAL ACTIVITY OF BENIN MEDICINAL PLANTS EXTRACTS USED IN THE TREATMENT OF SEXUALLY TRANSMITTED INFECTIONS ASSOCIATED WITH HIV/AIDS

Phytochemical screening of thirteen medicinal plants used in the treatment of sexually transmitted infections (STI), HIV/AIDS in Benin, showed that mucilage, gallic tannins and anthocyanins were the most common chemical groups. Water-ethanol (HE): 4/6 v/v, aqueous (A) and dichloromethane (DCM) extracts were prepared for each plant and tested for toxicity against shrimp larvae (Artemia salina Leach...

Alban G. Houngbeme,, Clément Gandonou, Boniface Yehouenou , Salomé D.S. Kpoviessi , Dominique Sohounhloue , Mansourou Moudachirou and Fernand A. Gbaguidi

Organic Chemistry and Naturals Products Teacher/University of Abomey-Calavi; Benin, 01 BP 06 Oganla Porto-Novo

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1739-45

1739-1745

2014

885

17.

POLYMERIC NANOPARTICLES AS POTENTIAL CARRIERS FOR TOPICAL DELIVERY OF COLCHICINE: DEVELOPMENT AND IN VITRO CHARACTERIZATION

The aim of the present study is to develop a nanoparticle formulation as a potential carrier for topical drug delivery. Colchicine loaded Nanoparticles (Colchicine-NPs) were prepared by the double emulsion solvent evaporation method using biodegradable and non biodegradable polymers alone or as binary mixtures. Based on the evaluation of the entrapment efficiency, the particle size and the % drug ...

Rawia Khalil*, Fahima Hashem , Heba Zaki and Silvia El-Arini

Department of Pharmaceutical Technology, National Research Centre, Dokki Cairo, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1746-56

1746-1756

1867

1376

18.

SOME TRANSITIONAL METAL IONS COMPLEXES WITH 3-{[(E)-(4-FLUOROPHENYL) METHYLIDENE] AMINO} BENZOIC ACID AND ITS MICROBIAL ACTIVITY

Some transitional metal ions complexes with 3-{[(Z)-(4-hydroxyphenyl) methylidene] amino} benzoic acid with general formula [M(L2)xH2O], [where M = Mn(II),Co(II), Ni(II),Cu(II), Zn(II), Pd(II) and Pt(II)metal ions and L=3-{[(E)-(4-fluorophenyl) methylidene] amino} benzoic acid ] have been synthesized and characterized on the basis of  elemental analysis,  conductance, magnetic susceptibility, IR...

Manohar V. Lokhande* and Mrityunjay R. Choudhary

Department of Chemistry, Sathaye College, Vile Parle (E), Mumbai- 400 057, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1757-66

1757-1766

1461

689

19.

DESIGN AND EVALUATION OF DICLOFENAC SODIUM BUCCAL MUCOADHESIVE FILM BY SOLVENT CASTING TECHNIQUE

Mucoadhesive buccal patches containing diclofenac sodium were prepared using the solvent casting method. HPMC used as bioadhesive polymer and different ratio of propylene glycol and glycerin also used. FT-IR and UV spectroscopic methods revealed that there is no interaction between Diclofenac sodium and polymers. The patches were evaluated for their physical characteristics like mass variation, dr...

G. Lakshmana Murthy *, V. Raghu Vamsi , Tirumala Devi , N. Narendra Babu, Sravya Ch , K. Masthaniah , Shaik Harun Rasheed and P. Kranti Kumar

Department of Pharmaceutics, Jagans College of Pharmacy, Nellore, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1767-75

1767-1775

3190

755

20.

ANTIDIARRHOEAL ACTIVITY OF LEAF EXTRACT OF ANOGEISSUS LATIFOLIA WALL IN EXPERIMENTALLY INDUCED DIARRHOEA IN RATS

Aim: To evaluate the antidiarrhoeal activity of methanolic leaf extract of Anogeissus latifolia. Material and Methods: The methanolic extract was evaluated using rodent animal models like castor-oil induced diarrhoea and castor-oil induced enteropooling. The phytochemical constituents were also planned to screen by using standardized methods. The plant is traditionally used for the treatment of...

G. Shashi Priya*, K. Hemamalini and M. Vijusha

Department of Pharmacology, Teegala Ram Reddy College of Pharmacy, Meerpet, Hyderabad, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1776-79

1776-1779

1839

488

21.

FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING FILMS OF MONTELUKAST SODIUM

Montelukast Sodium is a leukotriene receptor antagonist (LTRA) used for the treatment of asthma and to relieve symptoms of seasonal allergies. In present research work an attempt has been made to prepare mouth dissolving films of Montelukast Sodiumwere prepared using different polymers like PVA, HPMC by solvent casting method. The fast dissolving oral film evaluated for folding endurance, swelling...

Naziya Khatoon, N. G. Raghavendra Rao*, B. Mahipal Reddy

PG Department of Pharmaceutics, Jyothishmathi Institute of Pharmaceutical Science, Thimmapur, Karimnagar -505481, A.P. India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1780-87

1780-1787

3909

2558

22.

A PHARMACOPHORE BASED DRUG DESIGN APPROACH TO OVERCOME IMATINIB RESISTANCE AND GET MORE POTENT BCR-ABL TYROSINE KINASE INHIBITOR

BCR-ABL Tyrosine Kinase inhibitor is an ideal pharmacological target for Chronic Myeloid Leukemia (CML). After the effective use of Imatinib as a therapeutic agent for Chronic Myeloid Leukemia, resistance has been observed in much patience with the treatment of Imatinib. The main objective of this study is to develop some new novel BCR-ABL Tyrosine Kinase inhibitor for the treatment of Chronic Mye...

Abhishek Thakur

Department of Pharmaceutical Sciences; Birla Institute of Technology, Mesra, Ranchi -835215, Jharkhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1788-00

1788-1800

2154

616

23.

FORMULATION AND FINDING OUT THE EFFICACY OF THE HERBAL HAIR OIL OVER SIMPLE COCONUT OIL (PURIFIED) – A FORMULATION AND CLINICAL STUDY IN BANGLADESH

Hair fall is a very common phenomenon and a matter of concern within whatever young or aged. This study is formulated a herbal hair oil and made a clinical trial over selected person under the research and development unit at Routi Herbal Limited. To see the efficacy of the experimental oil made up of Kala Jera Toil (Nigella sativa) Narkal Toil (Cocos nucifera) Amloki (Emblica officinalis) Henna (...

Md. Shahinoor Rahaman Dulal*, Hasib Sheikh , Mohammad Abu Taher , Mohammad Sayeed Ur Rahaman , Zakia Rahman and M.A. Malek

Manager Production, Routi Herbal Limited and Routi Pharmaceuticals (Unani) Limited. Sadapur, Nagorkonda, Savar, Dhaka, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1801-05

1801-1805

2564

2159

24.

DESGINING, METHOD DEVELOPMENT AND STANDARDIZATION OF PROCESS FOR EXTRACTION OF MARKER COMPOUND FROM TERMINALIA CHEBULA FRUIT

The present study is done to study and optimize the process of enzyme-assisted extraction of Chebulinic acid from the dried fruit of Terminalia chebula. A selective extraction process after the treatment with enzymes is proposed by using 30% (v/v) methanol which releases increased yield of the Chebulinic acid, present in the dried fruit compare to aqueous extract. The optimal conditions were as fo...

Saroj Yadav*, Anoop Kumar and Om Prakash

Institute of Pharmaceutical Sciences and Research Center, Bhagwant University, Ajmer Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1806-10

1806-1810

1887

658

25.

AN IN SILICO STUDY ON HIV-1 PROTEASE WILD-TYPE AND MUTANT WITH INHIBITORS FROM ANNONA SQUAMOSA

Human immunodeficiency virus (HIV) is a lent virus that cause acquired immunodeficiency syndrome (AIDS), a state in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. HIV-1 protease is a retroviral aspartyl protease (retropepsin) that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV Wild type ...

Lisina KV* and Shanmughavel Piramanayagam

Department of Bioinformatics, Computational Biology Lab, DBT Bioinformatics Centre, Bharathiar University, Coimbatore-641 046, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1811-18

1811-1818

1550

933

26.

EVALUATION OF ANTIOXIDANT POTENTIALS OF SELECTED INDIAN MEDICINAL PLANTS

Oxidative stress is found to be one of the major causes of health hazards in the present global scenario. The traditional herbs and medicinal plants have been investigated for the presence of natural antioxidants, which have incredible effects in the prevention of various oxidative stress associated diseases. The objective of present investigation is to assess the antioxidant capacity and phytoche...

L.K. Kaja , P. V. Arjuna Rao , A. D. Naveen Kumar , B. Ganesh Babu and R. R Malla*

H.O.D, Department of Biochemistry, GIS, GITAM University, Visakhapatnam, Andhra Pradesh, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1819-29

1819-1829

1482

570

27.

EFFECT OF DIFFERENT EXCIPIENTS AND PACKAGING MATERIALS ON COMMERCIAL PREPARATION OF PROBIOTIC FORMULATION

Probiotic formulations are now widely accepted throughout the world for therapeutic applications as these organisms have a long history of safe use (GRAS). There are two main challenges to make a probiotic formulation viable for commercial utilization. The first one is the quality of health attributes that the probiotic organisms can confer and the second one is the stability of the formulation ti...

S. Das, D. Bhattacharjee, A. Manna, S. Basu, S. Chowdhury S. Mukherjee and B.K. Bhattacharyya*

Research and Development East India Pharmaceutical Works Ltd119, Biren Roy Road (West) Kolkata – 700061, West Bengal, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1830-36

1830-1836

1993

3059

28.

ANTI-ULCER EFFICACY AND SAFETY OF ANDA LEGHYAM A POLYHERBAL SIDDHA FORMULATION

Anda leghyam (AL) a herbo-animal Siddha formulation is administered for Gunmam (Acid peptic diseases) by many Siddha physicians popularly. Anti ulcerogenic activity of the AL has been studied using Aspirin-Pylorus ligation induced gastric ulcer methods (four groups/method, n=6, Aspirin 400mg/kg, Omeprazole 10mg/kg, AL 250,500mg/kg) in wistar albino rat models. Animals were sacrificed and their sto...

G.J. Christian*1, H. Mubarak , K. Yamini , T. Onesimus , S. Elansekaran , K. Vennila and L. Janani

National Institute of Siddha, Autonomous Institution under Dept. of AYUSH, Ministry of Health & Family Welfare, Govt. of India,Tambaram Sanatorium, Chennai - 47, Tamil Nadu, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1837-42

1837-1842

1818

556

29.

EVALUATION OF α – AMYLASE INHIBITORY ACTIVITY OF SOME CLINICALLY USED DRUGS

Finding out the alternative uses of the clinically proven and time tested drugs can be one of the best options for drug discovery research. In view of this the present study was carried out to evaluate α-amylase inhibitory activity of the some of the commonly used drugs. The drugs were procured as gift samples from pharmaceutical companies and were evaluated for in-vitro α-amylase inhibitory act...

Harish C. Rodda*, T. Sandhya and P. Swetha

Department of Pharmacognosy, Phytochemistry Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal – 506001, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1843-46

1843-1846

3292

750

30.

ANTIOXIDANT ACTIVITY OF SOYMIDA FEBRIFUGA ROXB. A. JUSS

In this present study, we investigated the phytochemical constituents screening and in-vitro antioxidant activity of hydro-alcoholic (methanol 70%v/v) extracts of Soymida febrifuga bark. Soymida febrifuga is a huge tree bearing deciduous foliage and having a tough bark belonging to the family Meliaceae. Traditionally the different parts of plant such as root, leaves, bark, and flower are used for ...

G. Veda Priya *, B. Ganga Rao and K. Swathi Priya K

Pharmacognosy and Phytochemistry, A.U College of Pharmaceutical Sciences, Andhra University Visakhapatnam, A.P, India-530 003.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1847-51

1847-1851

3097

872

31.

EVALUATION OF ANTI ULCER AND IN-VITRO ANTIOXIDANT ACTIVITIES OF AQUEOUS AND METHANOLIC EXTRACTS OF NEOLAMARCKIA CADAMBA LEAVES AND BARK IN WISTAR ALBINO RATS

The antiulcer activity of Aqueous and Methanolic extracts of Neolamarckia cadamba leaves and bark was investigated in Pylorus ligation and Aspirin induced ulcer models in Wistar albino rats. In both models the common parameter determined was ulcer index. Aqueous extract of Neolamarckia cadamba leaves (AENCL) at dose of 200mg/kg and 400 mg/kg produced significant inhibition of gastric lesion induce...

Vinay Kumar Inaparthi*, Patibandla Naresh Babu, Prasad K, Nagaraju B, Prasanthi K, Srinivasa

Department of Pharmacology, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram, West Godavari, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1852-58

1852-1858

2243

834

32.

ORAL DISSOLVING FILMS OF CHLORPHENIRAMINE MALEATE

In this present study, we investigated phytochemical constituents screening and In-vitro antioxidant activity of hydro-alcoholic (methanol 70%v/v) extracts of Soymida febrifuga bark. Soymida febrifuga is a huge tree bearing deciduous foliage and having a tough bark belonging to the family Meliaceae. Traditionally the different parts of plant such as root, leaves, bark, and flower are used for vari...

N. Prudvi Kanth*, G. Prasad and B. Vijay Kumar

Department of Pharmaceutics, Jangaon Institute of Pharmaceutical Sciences, Jangaon, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1859-73

1859-1873

2717

2389

33.

SYNTHESYS AND SCREENING OF ANALGESIC ACTIVITY OF SOME NOVEL PYRAZOLE

The present study was aimed to study the analgesic potency of some new pyrazole compounds. Various Quinazolinone clubbed Pyrazole derivative compounds (7a1, 7a2, 7b1, 7b2) were synthesized by using anthranilic acid as starting material as per standard chemical procedure. The synthesized compounds were characterized by physical and spectral analysis by using UV-visible spectrophotometer, Fourier tr...

Pratap Kumar Patra*, Ch. Niranjan Patra and Subasini Pattnaik

Associate professor, Department of Pharmaceutical Chemistry Sree Dattha Institute of Pharmacy, Sheriguda, Ibrahimpatnam, R.R Dist. Hyderabad, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1874-83

1874-1883

1880

639

34.

PHYTOCHEMICAL SCREENING AND ANTIFUNGAL ACTIVITY OF SEMECARPUS ANACARDIUM L. (AN ANTI-CANCER PLANT)

The spread of antibiotic resistant pathogens is one of the most serious menaces to successful treatment of microbial diseases. Medicinal and aromatic plants are widely used as traditional medicines and constitute a major source of natural organic compounds. Semecarpus anacardium Linn (Family: Anacardium), is a plant well known for its medicinal value in Ayurvedic and Siddha system of medicine. The...

Paras Jain*, Soni Kumari Singh, H.P. Sharma and Fauziya Basri

Laboratory of Plant Physiology and Biotechnology, University Department of Botany, Ranchi University, Ranchi, Jharkhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1884-91

1884-1891

3164

1553

35.

DEVELOPMENT OF VALIDATED RP-HPLC METHOD FOR QUANTITATIVE ESTIMATION OF RIVASTIGMINE HYDROGEN TARTRATE IN TRANSDERMAL DRUG DELIVERY SYSTEM

A fast simple sensitive precise, accurate and reproducible RP-HPLC method was developed and validated for the analysis of rivastigmine hydrogen tartrate in transdermal drug delivery system. Rivastigmine tartrate is soluble in water so it was used as solvent. The separation was conducted by using C-18 RP-HPLC column which was maintained at ambient temperature.The mobile phase consist 0.01M ammonium...

M. N. Kale

Sudhakarrao Naik Institute of Pharmacy college, Nagpur road, Pusad-445204, Dist. Yavatmal, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1892-02

1892-1902

2377

1556

36.

TOTAL PHENOLIC CONTENT AND ANTIOXIDANT POTENTIAL OF CUCURBITA MAXIMA (PUMPKIN) POWDER

As Antioxidant potential of many plants is mainly due to phenolic components such as phenolic acid, phenolic diterpense therefore total phenolic content and antioxidant potential of cucurbita maxima. (Pumpkin) powder was determined respectively by using Folin-Ciocalteu reagent and diphenyl-picryl-hydrazyl (DPPH) assay. In this method the antioxidants present in the plant extracts reacted with DPPH...

Bansode Ashwini Sopan*, Devhadrao Nitin Vasantrao and S. Bansode Ajit

Department of Quality Assurance, VJSM’S Vishal Institute of Pharmaceutical Education & Research Ale, Junnar, (Pune) 412409 Maharashtra, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1903-07

1903-1907

2150

2842

37.

EVALUATION OF PORTULACA OLERACEA LINN. FOR HYPOGLYCAEMIC EFFECTS

Hypoglycaemic and anti-hyperglycaemic effects of Portulaca oleracea Linn. (POL)  was evaluated in experimental rat models in vivo. The aqueous extract of POL was subjected to preliminary toxicity screening by an acute toxicity study in Wister albino rats. The POL was found to be safe in the doses used and there was no mortality up to a dose of 3000mg/kg orally after 24 hours. Hypoglycaemic effect...

Lalromawii*, A. Subhalakshmi Devi , U. Dhamaraj Meetei and R.K. Bharati Devi

Senior Resident, Department of Pharmacology, NEIGRIHMS, Mawdiangdiang, Shillong – 793018, Meghalaya, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1908-13

1908-1913

1558

706

38.

GC-MS PROFILING AND ANTHELMINTIC ACTIVITY OF ANTIGONON LEPTOPUS LEAVES

The study was designed to determine the phytocomponents and in-vitro anthelmintic activity of chloroform fraction of methanolic extract of Antigonon leptopus leaves. GC-MS analysis of chloroform fraction of the methanolic extract of Antigonon leptopuswas performed on a GC–MS equipment (Thermo Scientific Co. Thermo GC-TRACE ultra ver.: 5.0, Thermo MS DSQ II). The extract under study has been scre...

K. Sony Priya, K. Satyavathi, P. Bhojaraju, Y. Ratna Kumari, D. Venkatesh Prasad, M. Sesha Sai Durga, P. Mercy Preeti, K. Pardhava Lovaraju and Lakshmi Kanta Kanthal*

M. Pharma, AIC, (Ph. D), Associate Professor, Koringa College of Pharmacy, Department of Pharmacology, Korangi-533461, Tallarevu Mandal, East Godavari Dist., Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1914-18

1914-1918

2151

1191

39.

EVALUATION OF ANTIADIPOGENESIS ACTIVITIES OF SELECTED SPECIES OF CARALLUMA R. BR., BOUCEROSIA WIGHT & ARN. AND PREGNANE STEROID ON CELL LINES.

Back ground: The study was designed to determine antiadipogenesis properties of crude methanolic extracts from four species of Caralluma R.Br. such as Caralluma adscendens (Roxb.) R. Brown var. attenuata (Wight) Grav. & Mayur. (CAA), Caralluma adscendens (Roxb.) R. Brown var. fimbriata (Wall.) Gravely & Mayur. (CAF), Caralluma stalagmifera C.E.C. Fisch. (CS) and Caralluma stalagmifera C.E....

Madhuri Vajha , AmruthaVAudipudi , K.S.R. Murthy and C. Siva Rama Krishna *

Department of Pharmacognosy, Scientist, Laila Nutrceuticals, Vijayawada, Andhra Pradesh , India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1919-23

1919-1923

1487

856

40.

CATHEPSIN D LEVEL IN THE HUMAN GINGIVAL TISSUES AND SERUM OF PERIODONTITIS SUBJECTS

This study investigates the level of cathepsin D activity in the serum and gingival tissues of periodontitis subjects and healthy individuals. The cathepsin D activity (spectrophotometric assay) was measured in the gingival tissues and serum of control healthy individuals (group I) and periodontitis subjects (group II). Inflamed gingival tissue was obtained from 15 periodontitis patients (9 males ...

D.S. Pushparani* and S. Nirmala

Department of Biochemistry, SRM Dental College, Ramapuram, Chennai-600089, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1924-30

1924-1930

3021

669

41.

EVALUATION OF ACUTE TOXICITY STUDY AND HAIR GROWTH PROMOTING ACTIVITY OF TRICHUP TABLET

Hair loss problems can affect physical and mental health of human and have particular relevance during the aging process. In an effort to find solution of such problems, an attempt has been made to evaluate the hair growth promotion activity of a herbo-mineral Ayurvedic formulation, Trichup Tablet. Safety of drug was also evaluated by conducting acute toxicity study as per OECD guideline. For eval...

Hardik Soni*, Ekta Rabadiya , Maitreyi Zaveri , Sonal Patel , Ghanashyam Patel

Vasu Research Centre A division of Vasu Healthcare Pvt. Ltd. 896/A, GIDC, Makarpura, Vadodara – 390010, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).1931-36

1931-1936

1998

869

42.

IN VITRO QUALITATIVE AND QUANTITATIVE PHYTOCHEMICAL ANALYSIS OF ETHANOLIC AND 50% ETHANOLIC EXTRACTS OF TINOSPORA CORDIFOLIA, MOMORDICA CHARANTIA, CUCURBITA MAXIMA AND RAPHANUS SATIVUS

Phytochemicals are non-nutritive chemical constituents of plants which occur naturally in it such as Steroid, Terpenoids, Tannins, Carotenoids, Flavonoids, Alkaloids and Glycosides. The aim of the present study was to carryout qualitative and quantitative phytochemical analysis of ethanolic and 50% ethanolic extracts of Tinospora cordifolia (stems), Momordica chirantia (fruit), Cucurbita maxima (f...

Amol Gurav*, D.B. Mondal and H. Vijayakumar

Scientist, National Academy of Agricultural Research Management, Rajendranagar, Hyderabad (AP) – 500030, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1937-41

1937-1941

2210

2656

43.

ISOLATION AND CHARACTERIZATION OF MICROBES PRODUCING BACTERIOCIN FROM CURD, RAW MILK AND SOIL AND ITS PRESERVATIVE EFFECTS

Bacteriocins are proteinaceous substance produced by bacteria to inhibit the growth of similar or closely related bacterial strains. They are typically considered to be narrow spectrum antibiotics produced by both gram negative and gram positive range of bacteria which possess antimicrobial properties and inhibitory towards sensitive strains. Bacterocins are safer than antibiotic. They can be used...

Bamgbose Timothy* and Sumit Sharma

Department of Microbiology, University of Mysore, Manasagangothri Mysore- 570006, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1942-48

1942-1948

3405

1210

44.

FORMULATION AND DEVELOPMENT OF FLAVOXATE HYDROCHLORIDE EXTENDED RELEASE CAPSULES

Flavoxate Hydrochloride is an antispasmodic, mainly used for treating painful urination, urgency of urination and incontinence. The primary objective of the study was to formulate extended release capsules of Flavoxate hydrochloride to reduce dosing frequency and decreasing the associated side effects. The extended release capsules were formulated using extrusion spheronisation process with ethyl ...

K. Satyavathi*, M. Venu, P. Gayathri, P. Bhojaraju and L.K. Kanthal

Koringa College of Pharmacy, Department of Pharmaceutics, Korangi-533 461, Tallarevu (M), E.G. Dist., Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1949-56

1949-1956

2057

1614

45.

IN VITRO ANTI-INFLAMMATORY AND ANTI-ARTHRITIC ACTIVITY IN METHANOLIC EXTRACT OF COCCULUS HIRSUTUS (L.) DIELS. IN VIVO AND IN VITRO

The  present  study  deals  with  the   in  vitro  anti-inflammatory  and  anti-arthritic  activity  in  methanolic  extracts  of  in vivo (leaf and stem) and in vitro (callus) plant parts of Cocculus hirsutus. The previous phytochemical analysis of methanolic extract of Cocculus hirsutus has indicated the presence of several physiologically active phytochemicals such as phenols, ...

Deepika Arya*, Mukesh Meena, Neha Grover and Vidya Patni

Plant Pathology, Tissue Culture and Biochemistry Laboratory, Department of Botany, University of Rajasthan, Jaipur-302005, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1957-62

1957-1962

3100

1979

46.

SPECTROPHOTOMETRIC DETERMINATION OF MEROPENEM IN BULK AND INJECTION FORMULATIONS BY 1, 2 NAPHTHO QUINONE 4-SULPHONIC ACID (NQS) REAGENT

A simple and cost effective spectrophotometric method is described for the determination of Meropenem (MP) in pure and pharmaceutical formulations. The method is based on the formation of dark yellow colored chromogen when the drug reacts with 1, 2 naphtho quinone -4-sulphonic acid sodium salt (NQS) reagent in alkalline medium. The method involves the addition of excess NQS of known concentration ...

K. Raghu Babu and N. Aruna Kumari *

Assoc.Prof of Engineering Chemistry, Dept of HBS,GIET,Rajahmundry, Andhra Pradesh, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1963-67

1963-1967

1985

1126

47.

ANTI- CONVULSANT PROFILE OF AQUEOUS EXTRACT OF SAPINDUS LAURIFOLIA IN EXPERIMENTAL ANIMALS

Objective: The aim of the present study was to evaluatethe anti convulsant property of aqueous extract of Sapindus laurifolia in Pentylenetetrazole (PTZ) and MES induced convulsions in experimental models. Materials & Methods: The purpose of this study is to explore the anticonvulsant activity of ethanolic extract of Momordica tuberosa using Pentylenetetrazole and maximal electric shock induce...

N. Siva Kumar *, N. Raveendra Kumar and Parabattula B. Gangadhar

Associate Professor, Alluri Sitaramaraju Academy of Medical Sciences (ASRAM), Eluru, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1968-72

1968-1972

1750

711

48.

DESIGN AND EVALUATION OF TOPICAL HYDROGEL FORMULATION OF DICLOFENAC SODIUM FOR IMPROVED THERAPY

Topical gel preparations are intended for skin application or to certain mucosal surfaces for local action or transdermal penetration of medicament or for their emollient or protective action. Topical delivery of drugs can be achieved by incorporating drug into the gel matrix for effective delivery of drugs, thus avoiding first pass metabolism and for increased local action in pain management and ...

A. Salomy Monica*, and J. Gautami

Bharat Institute of Technology, Ibrahimpatnam, Rangareddy Dist-501510, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1973-80

1973-1980

10412

4183

49.

COMPARISON OF GC-MS ANALYSIS OF PHYTOCHEMICALS IN THE ETHANOLIC EXTRACTS OF MARCHANTIA LINEARIS LEHM & LINDENB. AND MARCHANTIA POLYMORPHA L. (BRYOPHYTA)

Bryophytes have unique aroma, taste and possess bioactive potential compounds with medicinal properties. Chemical studies of the bryophytes were limited in India due to the small size and expertise in identification of the species. Many of the bryophytes are used as folklore medicine by local tribes.  The solvent extracts results poor yield leads to insufficient for testing biological activity. I...

Remya Krishnan and K. Murugan K*

Associate Professor, Plant Biochemistry and Molecular biology Laboratory, Department of Botany, University College, Trivandrum 695 034, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1981-87

1981-1987

2151

1195

50.

IN VITRO EVALUATION OF ANTIMICROBIAL ACTIVITY OF MORINGA OLEIFERA AND MOMORDICA CHARANTIA SEEDS

The aqueous and methanol extracts of the seeds of Moringa oleifera (Family: Moringaceae) and the seeds of Mormordica charantia (Family: Cucurbitaceae) were screened for their antimicrobial activity against three human pathogenic bacterial strains and three fungal strains by agar-well diffusion assay.  The pattern of inhibition varied with the solvent used for extraction and the microorganisms tes...

F. G. Shoba*, V.A. Babu, M. Parimala and J. Sathya

P.G. & Research Department of Zoology, Voorhees College, Vellore – 632001, Tamilnadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1988-93

1988-1993

2295

908

51.

FORMULATION AND EVALUATION OF PREDNISOLONE LOADED MICROSPONGES FOR COLON DRUG DELIVERY: IN-VITRO AND PHARMACOKINETIC STUDY

The purpose of this study was to develop prednisolone-loaded microsponges for colon specific drug delivery. The microsponges formulations were prepared by quasi-emulsion solvent diffusion method employing eudragit RS 100 as a polymer. The compatibility of the drug with formulation components was established by Fourier Transform Infra-Red (FTIR) spectroscopy. Afterwards, microsponge formulations we...

Sonali *, Rahul Pratap Singh and Sunil Kumar Prajapati

Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221 005, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1994-05

1994-2005

3746

1681

52.

PHYTOCHEMICAL, ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC STUDY OF CRUDE HYDROALCOHOLIC EXTRACT OF AERIAL PARTS OF MARRUBIUM VULGARE L. IN NORMAL AND STREPTOZOTOCIN INDUCED-DIABETIC WISTAR RATS

The phytochemical screening, the antihyperglycemic and antihyperlipidemic effects of crude hydroalcoholic extract of aerial parts ofMarrubium vulgare L. were evaluated in normal and Streptozotocin- induced diabetic in Wistar rats. First, the preliminary phytochemical test to identify the chemical constituents of crude hydroalcoholic extract of aerial parts of M. vulgare was carried. Next, the rats...

R. Azzi*, F. Lahfa and R. Djaziri.

Department of Biology, Faculty of Natural Sciences and Life Sciences of the Earth and the Universe, University Tlemcen 13000, BP 119, Algeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).2006-13

2006-2013

1845

731

53.

EXTRACTION, ISOLATION AND CHEMICAL STRUCTURE ELUCIDATION OF DAIDZEIN FROM BARK OF ACACIA ARABICA (LAM.) WILLD OF BHOPAL, MADHYA PRADESH, INDIA

Purpose: To extract, isolate and identify daidzein from the bark of Acacia Arabica (Lam.) Willd of Bhopal, Madhya Pradesh, India. Methods: Succesesive methanolic extract from the bark of Acacia arabica was subjected to column chromatography and fractionated by benzene, n-butanol, and acetone successively. Eluents having similar Rf values were pooled together. These pools were subjected to flavonoi...

Saurabh Rajvaidhya*, Gajendra Kamal Singh, Badri Prakash Nagori and Shashi Alok

T .I. T. College of Pharmacy, Bhopal, Madhya Pradesh-462021, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).2014-21

2014-2021

4537

1823

54.

PHARMACOGNOSTICAL INVESTIGATION AND EVALUATION OF FICUS CARICA FRUIT EXTRACT FOR ADAPTOGENIC ACTIVITY

Ficus carica is the common fig fruit belonging to the family Moraceae, The Pharmacognostical studies of the half ripened fruits were carried out using the various micro-chemical tests. The dried fruits were subjected to extraction using 90 % ethanol and this extract was further evaluated for the adaptogenic activity. Swim Endurance test in mice and Cold Stress model in rats was used to screen the ...

Dayanand Kannur * and Kishanchandra Khandelwal

SCES’S, Indira College of Pharmacy, Tathwade, Pune.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).2022-32

2022-2032

2463

1020

55.

A NOVEL METHOD OF ECONOMICAL CULTIVATION OF MEDICINALLY IMPORTANT MUSHROOM, GANODERMA LUCIDUM

Ganoderma lucidum has been widely used as a herbal medicine in many pacific countries. Ithas been worshipped as a kind of herbal medicine, the emperors of the great Japanese and Chinese dynasties drank with their special teas and mushroom concoctions to achieve greater vitality and longer life. A protocol has been developed for the cultivation of G. lucidum on billets of Poplar (Populus deltoides)...

Sona Singh*, N.S.K. Harsh and P.K. Gupta

Forest Pathology Division, Forest Research Institute, Dehradun-248006, Uttarakhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(4).2033-37

2033-2037

2196

7090

56.

EVALUATION OF ANALGESIC ACTIVITY OF SOME NOVEL SUBSTITUTED L-ARGININE ANALOGUES

A series of novel L-arginine analogues were synthesized characterized and screened for analgesic activity by acetic acid induced analgesia model. The purity of the synthesized compounds has been characterized by various analytical techniques such as UV, FTIR and TLC. The synthesized compounds were evaluated for analgesic activity by acetic acid induced analgesia in mice using paracetamol as the st...

S. K. Arifa Begum, M. Madhuri, A.Rajani and K. Hemamalini*

Associate Professor & HOD, Department of pharmacology, Teegala Ram Reddy College of Pharmacy, Meerpet, Hyderabad, AP, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).2038-40

2038-2040

1432

597

57.

FORMULATION AND EVALUATION OF ANTHRALIN MICROEMULSION GEL USING KARANJ OIL

The present research work was conducted to formulate and evaluate Anthralin microemulsion gel using Karanj oil with an objective of improving solubility of the Anthralin. The pseudo ternary phase diagrams were developed for combinations of Karanj oil as the oil phase, Span-20 as surfactant and as Capryol 90 as cosurfactant using water titration method. Microemulsions obtained were analyzed for top...

G.R. Dixit* and A.B. Shende

Assistant Prof, Department of Pharmaceutics, Priyadarshini J. L. College of Pharmacy, Electronic zone building, M.I.D.C., Hingna road, Nagpur -440016, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).2041-50

2041-2050

3108

836

58.

EVALUATION OF IN-VITRO ANTI-OXIDANT ACTIVITY OF SOME SYNTHESIZED NOVEL L-ARGININE ANALOGUES

A series of novel L-arginine analogues were synthesized and screened for in-vitro anti-oxidant activity by Nitric oxide (NO) scavenging and 1-1-diphenyl-2-picrylhydrazyl (DPPH) scavenging methods. The purity of the synthesized compounds has been characterized by various analytical techniques such as UV, FTIR and TLC. The synthesized compounds were evaluated for in-vitro anti-oxidant activity by NO...

S. K. Arifa Begum , M.Madhuri , A.Rajani and K. Hemamalini *

Associate Professor & HOD, Department of pharmacology, Teegala Ram Reddy College of Pharmacy, Meerpet, Hyderabad

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).2051-54

2051-2054

1527

422

59.

EVALUATION OF EFFICACY AND SAFETY OF GEMIFLOXACIN IN CHRONIC BRONCHITIS PATIENTS

The study aimed to assess the efficacy and safety of Amoxicillin/Clavulanate 625 mg and Amoxicillin/Clavulanate 1 gram in chronic bronchitis patients. Chronic bronchitis, a type of COPD defined by a productive cough that lasts for 3 months or more for at least 2 years, other symptoms include wheezing and breathlessness, upon exertion. It is caused by recurring irritation to the epithelium of bronc...

Sandesh Kumar Visoriya*, Sridevi Muthusivam , Jayasutha J , Sourabh Kosey and Shashi Alok

Clinical Research Associate-QC, MTR PVT. LTD. Chennai Tamil Nadu 600 059

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).2055-59

2055-2059

1512

518

60.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC ASSAY METHOD FOR DETERMINATION OF LORNOXICAM IN SELF EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS) FORMULATION

The objective of the present work was to development and validation of stability indicating RP-HPLC assay by applying different stress degradation conditions on lornoxicam in Self Emulsifying Drug Delivery System (SEDDS) formulation. HPLC separation was achieved on analytical technique using C-18 column and mobile phase of Acetonitrile: Methanol (65:35, v/v) at a UV detector. The lornoxicam drug c...

V.V. Chopade* and P.D. Chaudhari

Instutute of Pharmacy, National Institute of Medical Sciences (NIMS) University, Shobha Nagar, Jaipur-Delhi Highway, Jaipur – 303121, Rajasthan, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).2060-65

2060-2065

1796

768

61.

FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF VERAPAMIL HYDROCHLORIDE

Sustained release matrix tablets reduce the frequency of the dosing and increase the effectiveness of the drug by localization at the site of action, providing uniform drug delivery. Sustained release matrix tablets of verapamil hydrochloride were prepared by using HPMC K15M, Xanthan and Guar Gum polymers with different concentration in various batches of the formulations to facilitate the drug re...

Kondeti Ranjith Reddy*, Grace Rathnam, I. Kiran, Shalem Raju and Kranti Sri Mulpuri

C.L. Baid Metha College of Pharmacy, Thoraipakkam, Old Mahabalipuram Road, Chennai-600096, Tami Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).2066-73

2066-2073

3427

789

62.

FORMULATION & EVALUATION OF ITOPRIDE HCL SUSTAINED RELEASE PELLETS P.

The present work is aimed to formulate Itopride HCl sustained release pelletsusing ethyl cellulose N50 such ashydrophobic polymer by employing the solution/suspension layer technique. The drug excipients compatibility study was carried out by Furor Transform Infrared spectroscopy (FTIR) which reveals no interaction between drug and excipients. Total 12 batches were formulated. Six formulations wer...

P. Sambha Siva Rao*, G. Raveendra Babu , T. Kala Praveen, P. Sri Lakshmi Surekha and M. Chandra Shekhar

Associative Professor, Department of Pharmaceutics, Vijaya College of Pharmacy, Munaganur (v), Hayath Nagar, Hyderabad, Ranga Reddy District -501511, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).2074-83

2074-2083

2962

1578

63.

STEREOSTRUCTURE, ANTIMICROBIAL AND CYTOTOXIC ACTIVITY OF CYCLO-HEXENE, CYCLOHEXANOL AND PYRIDINE DERIVATIVES SYNTHESIZED FROM CHALCONES

The main objective of this work is to study the stereostructures and biological activity of some highly substituted cyclohexenes, cyclohexanols and the intermediates there in. In order to get the desired cyclohexenes, the  synthesis of cyclohexanols  2,4-bis(4-chlorobenzoyl)-1-(4-chlorophenyl)-3,5-bis(4-methoxyphenyl)-and 2,4-bis(4-chlorobenzoyl)-1,3,5-tris(4-chlorophenyl)-cyclohexan-1-ols (1b a...

Habiba Tahira Hussain , Mohammad Osama* and Wajid Hussain

Department of Chemistry, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).2084-94

2084-2094

1670

931