Solid lipid nanoparticles (SLN) are aqueous colloidal dispersions, the matrix of which comprises of solid biodegradable lipids. They are introduced in 1990 as an alternative carrier system to traditional colloidal carriers, such as emulsions, liposomes and polymeric micro- and nanoparticles. SLN combine advantages of the traditional systems but avoid some of their major disadvantages. They exhibit...
Recently, heterocyclic compounds analogues and their derivatives have attracted strong interest in medicinal chemistry due to their biological and pharmacological properties. The small and simple benzothiazole nucleus possesses numerous biological properties like - antitumor, antimicrobial, anti-inflammatory, anticonvulsant, and antidiabetic activities. These activities are also possessed by its s...
EVALUATION OF ANTIOXIDANT, WOUND HEALING AND ANTI- INFLMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES OF FICUS RELIGIOSA
The present study deals with evaluation of antioxidant, wound healing and anti-inflammatory activity of ethanolic extract of leaves of Ficus religiosa. The ethanolic extract prepared by maceration technique was subjected to screen for antioxidant activity using DPPH radical scavenging method and wound healing activity using incision, excision, histopathological and dead space wound model and the s...
DASAPUSHPAM: THE TRADITIONAL USES AND THE THERAPEUTIC POTENTIAL OF TEN SACRED PLANTS OF KERALA STATE IN INDIA
The Western Ghats of Kerala is famous for its medicinal plant wealth and the tradition of indigenous system of therapy, specifically the Ayurveda. Dasapushpam constitute a group of ten potential herbs which are culturally and medicinally significant to the people of Kerala in India. They are a group of ten herbs with which the ladies decorate their hairs and dance the Thiruvathira Kali on the day ...
Pelletization process first came into existence way back during the 1950s, when the first product was introduced to the market. These pelletized dosage forms have gained popularity considerably from then because of their distinct advantages, such as ease of capsule filling because of better flow properties of the perfectly spherical pellets; enhancement of drug dissolution; ease of coating; sustai...
The present study was aimed to evaluate the antioxidant activity of A.sessilis plant extracts in different solvents. The antioxidant activity was studied by phosphomolybdate method and DPPH method. In phosphomolybdate method the highest activity was shown by methanolic extract (12.044 mM of ascorbic acid eqvt/gm of sample). The highest radical scavenging activity by DPPH method was found in methan...
Most of the drugs in the developmental pipeline are emerging from the High-Throughput Screening methodology resulting in increased molecular weights and thus consequential bioavailability problems. The bioavailability issue can be due to insufficient solubility of permeability. Most compounds face the solubility problems. Hence, with the advancement of chemical science, the need of development of ...
RP-HPLC METHOD FOR SIMULTATANEOUS DETERMINATION OF AMLODIPINE BESYLATE, VALSARTAN, TELMISARTAN, HYDROCHLOROTHIAZIDE AND CHLORTHALIDONE: APPLICATION TO COMMERCIALLY AVAILABLE DRUG PRODUCTS
A simple, precise and stability-indicating HPLC method was developed and validated for the simultaneous determination of anti-hypertensive drugs Amlodipine Besylate, Valsartan, Telmisartan and diuretics Hydrochlorothiazide and Chlorthalidone. The separation was achieved on Cosmosil PAQ (150 mm × 4.6 mm) 5 μm column with gradient flow. The mobile phase at a flow rate of 1.0 mL min−1 cons...
The synthesis of gold nanoparticles has received considerable attention and has been a focus of research due to their high chemical and thermal stability, fascinating optical, electronic properties, and promising applications such as nanoelectronics, biomedicine, sensing, and catalysis. Different physical and chemical methods for gold nanoparticles synthesis are known but these methods are either ...
The poor dissolution rate of water-insoluble drugs is still a major problem conforming the pharmaceutical industry. The most common method for improving the solubility is by increasing the surface area of the drug through micronization. But, in practice the effect of micronization is often disappointing, especially when the drugs are encapsulated or tablet. It is generally recognized that low solu...