Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
A COMPARATIVE STUDY OF EFFICACY AND SAFETY OF ORAL DICLOFENAC AND DECREASED DOSE OF DICLOFENAC PLUS TOPICAL DICLOFENAC IN TREATMENT OF KNEE OSTEOARTHRITIS
Objectives: To compare efficacy and safety of topical plus reduced dose of diclofenac to oral diclofenac in therapeutic dose. Method: The study was prospective, comparative and randomized, which included 50 patients suffering from knee osteoarthritis. Patients were randomized to receive either - oral diclofenac alone (50 mg thrice daily) (therapy1) or decreased dose of oral diclofenac and topi...
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COMPARATIVE HISTOLOGICAL, HISTOCHEMICAL AND PHYTOCHEMICAL STUDIES OF THE RAW DRUG JIVANTI FROM DIFFERENT RAW DRUG MARKETS OF KERALA
Jivanti is considered a stimulant and tonic in Ayurvedic literature. Its medicinal use dates back to about 4500 to 1600 BC, as mentioned in classical texts. Holostemma ada- kodien and Leptadenia reticulata are the two plants used in Ayurveda as source plants of the drug Jivanti. Roots of these plants are used in several Ayurvedic preparations. Though Ayurvedic Formulary of India mentions Leptadeni...
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HIGH PRESSURE LIQUID CHROMATOGRAPHIC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF ACYCLOVIR IN BULK AND MARKETED FORMULATION
A simple, selective, rapid and economical High Performance Liquid Chromatography (HPLC) method was developed for estimation of Acyclovir in bulk and marketed formulation. Chromatographic separation and estimation was achieved in a run time of 6.482 minutes on Hemsil C18- 5U (250 × 4.6 mm, 5μm) using Acetonitrile and pH adjusted water (6.74) in the ratio of 10:90 v/v at flow rate of 0.5ml/min. ...
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SOLID SUPPORTED MICROWAVE ASSISTED RAPID SYNTHESIS OF 1, 3, 4 OXADIAZOLES
We have carried out solid supported ,solvent free condition, microwave assisted rapid synthesis of 1- (2,5- substituted diphenyl)-1, 3, 4- oxadiazol -3(2H) - yl) ethanone (3a-3k) by cyclization of N'- (substituted phenyl methylidene) substituted benzohydrazide (2a-2k) in the presence of acetic anhydride and silica gel ( solid support) for 3-4 minutes by microwave irradiation giving excellent...
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SUICIDE RISKS AMONG ADOLESCENTS: A LOOK BEHIND THE BLACK CURTAIN
This review article investigates the prevalent existence of suicide along with its risk factors and contributing factors leading to the culmination of them all, in an attempt to look behind the black curtain. Suicide is the result of an unbalanced scale between the good and bad. Every year 300,000 teenagers attempt and succeed at suicide worldwide. A set of emotions and unpleasant thoughts develop...
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PRE-FORMULATION CHARACTERIZATION OF CHELATED AMINO ACID COMPLEXES
Amino acid chelated complexes were synthesized and characterized to determine their purity. The purity of the complexes was found to be ranging from 42-75%. The HPLC method for determination of free amino acid content in the complexes was developed and validated and found to be linear, precise and accurate within concentration range of 0.157 mg/mL to 20.14 mg/mL. The method was used to estimate ...
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DESIGN AND SYNTHESIS OF NOVEL MYCOBACTERIUM TUBERCULOSIS DHFR INHIBITORS
A series of 2,4-diaminotriazines were synthesized as Mycobacterium tuberculosis(Mtb) dihydrofolatereductase (DHFR) inhibitors. These derivatives were evaluated in whole cells by employing resazurinmicrotitre plate assay (REMA) against MtbH37Rv. Further, these were tested against other gram positive and gram negative bacterial strains to check specificity for Mtb. Cytotoxicity assessment was perfor...
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POSSIBLE RETRIEVAL OF ORGANOCHLORINE INDUCED RENAL TOXICITY IN FISH BY AQUEOUS ROOT EXTRACT OF WITHANIA SOMNIFERA: IN VIVO STUDY
The present study was aimed to assess the reno-protective impact of aqueous extract of root of Withania somnifera (WSR) commonly known as Ashwagandha against organochlorine induced renal toxicity in fish Clarias batrachus (Linn.).Fishes were exposed to 4ppb concentration of commercial brand Endocel, an organochlorine pesticide for one week and two week to prepare the toxic model. These toxic group...
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SYNTHESIS AND BIOLOGICAL EVALUATION OF COUMARIN DERIVATIVES AS ANTI-INFLAMMATORY AGENTS
All the newly synthesized Coumarin derivatives have shown considerable anti-inflammatory activity. In the present research work, we synthesized a series of novel Coumarin derivatives. The Coumarin derivatives such as substituted 7-hydroxy-4-methyl-2H-chromen-2-one and substituted 6-chloro-7-hydroxy-4-methyl-2H-chromen-2-one were synthesized from substituted benzoyl chloride. The chemical structure...
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DEVELOPMENT AND OPTIMIZATION OF FAST DISSOLVING TABLETS OF PROMETHAZINE THEOCLATE USING 32 FULL FACTORIAL DESIGN
This research work aimed at developing and optimizing fast dissolving tablets of Promethazine Thecolate by direct compression technique. In the investigation, a 32 full factorial design was used to investigate the joint influence of two formulation variables (amount of superdisintegrants): amount of sodium starch glycolate and crospovidone. The tablets were evaluated for its percent friability and...
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