STUDIES ON PHYTOCHEMICAL, ANTIBACTERIAL AND ANTIOXIDANT POTENTIALS FROM THE ROOTS OF BOERHAVIA ERECTA. L.
Boerhavia erecta is a weedy herb of the family Nyctaginaceae and is commonly available in almost all places. The present study is so designed for phytochemical screening of the plant as well as its antibacterial and antioxidant activities of the root extract of B. erecta. The whole plant was collected in and around Chennai. Phytochemical screening of acetone extract of B. ere...
OLEANANE-TYPE TRITERPENOID SAPONIN OF MOMORDICA CYMBALARIA EXHIBITS NEUROPROTECTIVE ACTIVITY IN DIABETIC PERIPHERAL NEUROPATHY BY AFFECTING THE POLYOL PATHWAY
Momordica cymbalaria Fenzl (Cucurbitaceae) fruit powder and extracts are reported to have Type 1 antidiabetic activity in experimental diabetic models. The objective of this study was to investigate the neuroprotective action of an oleanane-type triterpenoid saponin isolated from the plant in diabetic peripheral neuropathy (DPN) by in vivo and in vitro methods. Male Wistar rats were rendered diabe...
COMPARISON OF EFFICACY OF FIVE VARIOUS COMMERCIAL PRODUCTS OF CIPROFLOXACIN AGAINST STAPHYLOCOCCUS AUREUS AND PSEUDOMONAS AERUGINOSA
A study was undertaken to evaluate the efficacy of five various commercial products of ciprofloxacin (a broad spectrum antibiotic), manufactured by different pharmaceutical companies. The drug was evaluated for their performance based on equivalent MIC breakpoint, which is a measure of efficacy of drugs against Staphylococcus aureus ATCC6538 and Pseuomanas aeruginosa ATCC25668 when tested in vitro...
FORMULATION DEVELOPMENT AND EVALUATION OF pH TRIGGERED IN SITU OPHTHALMIC GEL OF EPINASTINE HYDROCHLORIDE
The poor bioavailability of ophthalmic solutions caused by dilution and drainage from the eye can be overcome by using in situ forming ophthalmic drug delivery system prepared from polymer that exhibit reversible liquid–gel phase transition. The objective of the study was to develop optimized formulation of in situ ophthalmic gel of Epinastine hydrochloride, an antihistaminic drug, using a p...
Diabetes mellitus is one of the most common metabolic disorders that cause micro and macro vascular complications. Because of additive effects of hyperglycaemia and hyperlipidaemia for cardiovascular disease, serum lipid and glucose level should be closely monitored in diabetes. Chronic Hyperglycaemia resulting from diabetes has profound effects on nearly every system of the body. The toxic effect...
IDENTIFICATION AND QUANTIFICATION OF PHENOLIC COMPOUNDS FROM OPERCULINA TURPETHUM (L.) SILVA MANSO LEAF BY HPLC METHOD
Plants served as potent sources of bioactive compounds since ages. The understanding of phytochemical constitution of each and every plant on earth is the preliminary and the most important step in drug discovery. As Operculina turpethum(L.) Silva Manso is traditionally used for various ailments, the understanding of phytochemical composition of the plant is very essential. The present study was...
SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND PETRA OSIRIS MOLINSPIRATION (POM) ANALYSES OF DICARBOXYLIC ACID AMIDES
Six new Phthalic acid amides of the general formula C8H5O3-NH-R were prepared by the reaction of Phthalic anhydride with various amines namely Glycine, N, N-diphenyl amine, 1-naphthyl amine, 4-amino toluene-3-sulphonic acid, Toluene-p-sulphonamide, m-nitro aniline. The synthesized compounds were characterized by using IR, 1HNMR & 13CNMR spectroscopy. Petra Osiris Molinspiration (POM) a...
Protein glycation is a spontaneous post translational modification of proteins by excess sugars causing formation of advanced glycation end products (AGEs) in diabetic individuals and responsible for diabetes complications. A wide variety of anti-glycating agents have been reported & recently there has been interest in natural products with anti-glycation properties. Momordica charantia L (M. ...
DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF PREGABALIN, METHYCOBAMIN, AND ALPHA LIPOIC ACID IN MULTICOMPONENT DOSAGE FORM
Objective: To develop and validate a novel and easy first order derivative spectroscopic method for the simultaneous determination of multicomponent dosage form which contains Methylcobalmine, Alpha lipoic acid and Pregabaline. Method: Measurement was achieved by selecting different Zero crossing points i.e ZCP for Methylcobalamine and Alpha lipoic acid at 436.24 nm, ZCP for Alpha lipoic acid and ...
EFFECT OF ORAL ADMINISTRATION OF VITAMIN A ON BLOOD GLUCOSE LEVEL IN RABBITS AND ITS POSSIBLE INTERACTIONS WITH COMMONLY USED ORAL ANTIDIABETIC AGENTS
In diabetes mellitus antioxidant vitamins are commonly employed to prevent or mitigate the long term complications of the disorder. Diabetic retinopathy, nephropathy, coronary and cerebral vascular insufficiency are examples of such complications. They are more common in Type 2 diabetes mellitus. The present study was conducted to observe the effect of Vit A on blood glucose level and its possible...