SYNTHESIS, CHARACTERIZATION AND ANALGESIC ACTIVITY OF SEVERAL NEW N-SUBSTITUTED PHTHALIMIDE ANALOGUES
The synthesis, characterization and spectroscopic studies of new N-substituted pthalimide analogues 2–7 with analgesic activity were described. The compounds were synthesized using phthalic anhydride with various appropriate amines (Triazolamine, Benzocaine, p-Nitro-aniline, pyrazinamide, Phenazone and glycine) in reflux synthesizer. The purity of the compounds was determined by TLC. With the ph...
DETECTION OF RHINOVIRUS AND SOME DNA/RNA VIRUSES BY REVERSE TRANSCRIPTASE REAL-TIME PCR AND THEIR IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH ACUTE RESPIRATORY TRACT INFECTION IN IRAQ: MOLECULAR AND IMMUNOLOGICAL STUDY
Background and Objectives: Acute upper respiratory tract infections are the most frequent acute illnesses worldwide. This study has been undertaken for determining the diagnostic importance of Human Rhinovirus and other associated DNA/RNA viruses including human Respiratory Syncytial virus; Human Metapneumovirus; Human parainfluenza virus 1-4; human coronavirus; Human B, C, and E Adenovirus; and H...
Snake venom is cocktail of various enzymes, toxins. Snake venom components have major role as therapeutics application in current drug industry. Snake venom toxins plays vital role as one of the major component in case of bite and most of the toxins are lethal which are of various types such as cardio-toxins, myotoxins and neurotoxins etc. The Indian Cobra neurotoxins sequences were retrieved form...
EFFECT OF ANGIOTENSIN-CONVERTING ENZYME INHIBITORS ON SERUM AMYLASE AND LIPASE IN PATIENTS WITH HYPERTENSION
Introduction: Angiotensin-converting enzyme (ACE) inhibitors are a class of potential drugs used as first-line agents for the treatment of hypertension and heart failure in physiologically young patients despite its side effects. Apart from the other common side effects, they are known to induce bradykinin release which alters vascular permeability leading to pancreatic edema resulting in intrapan...
THE EFFECT OF PHYTIC ACID ON RATE OF STARCH DIGESTIBILITY IN VICIA FABA AND WHITE WHEAT BREAD IN VITRO
ABSTRACT: The effect of the phytic acid on starch digestibility was studied in vitro. Starch digestibility was found to correlate negatively with the phytic acid content of the food tested.When sodium phytate was added (equivalent to 2% of phytic acid based on the starch portion), it was noticed that the rate of Viciafabastarch digestion by human saliva and at human body temperature (37°C) was de...
Dapagliflozin (DAPA) is a drug of gliflozin class. It is a white crystalline solid. Dapagliflozin is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity. Dapagliflozin blocks glucose reabsorption into the kidney, resulting in the elimination of blood glucose through the urine. DAPA is not official in any pharmacopeia. It comes under EU Pharmaceutic...
Diabetic neuropathy is one of the most serious microvascular complications of diabetes, which appears in about 50% of the patients suffering from diabetes. It is a nerve disorder caused by diabetes, characterized usually by numbness, pain or tingling in the feet or legs, which can lead to serious problems. Patients with diabetic neuropathy suffer from various types of pain. The underlying mechanis...
The purpose of this research was to develop novel solid dispersions (SDs) of BCS class IV drug, canagliflozin hemihydrate (CFZ) using Eudragit® E PO (EE PO) as a carrier, to enhance its solubility and dissolution rate. Solvent evaporation technique was used to prepare SDs. The SDs were evaluated for saturated solubility, in-vitro dissolution study, solid-state characterization using FTIR, DSC, XR...
The purpose of this study was to develop and optimise the formulation of mucoadhesive patches of Diltiazem hydrochloride using chitosan as base matrix. The patches were prepared by solvent casting method. PVP (K30) and propylene glycol were introduced into the patches formulae to improve the filming properties. The patches were found to be smooth in appearance, uniform in thickness, weight, and ...
EVALUATION OF BONE MARROW FOR HEMATOLOGICAL ANOMALIES IN INDIAN PEDIATRIC AND ADULT PATIENTS: A SINGLE TERTIARY CARE CENTER STUDY
Bone marrow aspiration can determine the metastatic deposits, degree of cellularity and fibrosis readily. A retrospective analysis of bone marrow aspiration and biopsy, in children and adult patients with hematological anomalies, were performed in 674 cases for different indication of hematological abnormalities from January 2013 to March 2014. Cases were analyzed in detail regarding clinical, hem...