Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
METAPHORICAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (2D & 3D-QSAR) ANALYSIS OF TYLOPHORINE DERIVATIVES AS EFFICACIOUS IN ANTIMALARIAL DRUG DESIGN
Quantitative Structure-Activity Relationship (QSAR) for tylophorine derivatives acting as Plasmodium kinases inhibitors has been developed. The proposed 2D-QSAR model was found to be statistically significant concerning training, cross-validation, and external validation. The contribution of carbon chains with aromatic and electronegative features are found to be the most important descriptors in ...
2955
1024
CORRELATION BETWEEN URINARY MICROALBUMIN, GLYCOSYLATED HAEMOGLOBIN AND SERUM MAGNESIUM IN TYPE 2 DIABETIC PATIENTS
Background and Objectives: Diabetes mellitus comprises a group of common metabolic disorders that share the phenotype of hyperglycemia. One of the leading causes of diabetes mellitus related morbidity and mortality is diabetic nephropathy. The earliest stage of diabetic nephropathy is Microalbuminuria, which is the excretion of extremely small quantities of albumin in the range of 30 - 300 mg/day....
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SYNTHESIS, PHARMACOLOGICAL ACTIVITY AND HYDROLYTIC BEHAVIOUR OF MUTUAL PRODRUGS OF IBUPROFEN
For reducing the gastrointestinal (GI) toxicity associated with ibuprofen (IBU), its carboxylic group was masked by synthesizing its mutual prodrugs with propyphenazone by direct coupling and by using spacer technique (amino acid was taken as a spacer). The structures of synthesized prodrugs were confirmed by 1H-NMR, 13C-NMR, Mass and FT-IR spectral methods, and their purity were established by ...
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2260
QUALITY OF LIFE IN PATEINTS WITH PSORIASIS IN OSMANABAD REGION OF INDIA: A SINGLE CENTRE STUDY
The prevalence of psoriasis has a deep negative impact on Quality of life (QoL) daily. It has been classified under psychophysiological disorders. The prime objective of the present study is to evaluate and assess the Quality of Life (QoL) of psoriasis patients in Osmanabad region of India. A retrospective analyzing study was carried out on 52 psoriatic patients attending outpatient and inpatient ...
3314
1025
QSAR STUDIES ON PPARγ AGONIST 2- ALKOXYDIHYDROCINNAMATES WHICH USE AS LEAD MOLECULE FOR THE SYNTHESIS OF NEW COMPOUNDS TO TREAT DIABETES AND NEUROLOGICAL DISORDER
Quantitative Structure-Activity Relationships (QSAR) is based on the assumption that the activity of a certain chemical compound is related to its structure. More precisely, this approach says that the activity or the property is related to the chemical structure through a certain mathematical algorithm or rule. Quantitative structure-activity relationship (QSAR) analysis used to understand the st...
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ANALYSIS OF THE CHANGES IN PRICING REGULATION ON LEADING ANALGESICS MEDICINES PRICES AND UTILIZATION IN BULGARIA
In 2004, the new pricing regulation was enforced in Bulgaria. It liberates the OTC medicines pricing procedure from reference pricing to registration according to marketing authorization holder proposal. The goal is to analyse the changes in the pricing regulations concerning OTC and its impact on prices and utilization of analgesic medicines. Two main hypotheses are tested in the study. H1: The ...
2753
970
IN VITRO AND IN VIVO EVALUATION OF DICLOFENAC POTASSIUM LYOPHILIZED ORALLY DISINTEGRATING TABLETS
Diclofenac Potassium, a sparingly soluble non-steroidal anti-inflammatory drug, was taken as candidate for decreasing the onset of action time and increasing its bioavailability by overcoming its first pass metabolism. Diclofenac Potassium orally disintegrating tablet (ODT) formulations were developed using lyophilization technique. The freeze dried tablet formulations were prepared by freeze-dryi...
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IN VITRO EVALUATION OF ANTIBACTERIAL AND ANTIFUNGAL PROPERTIRS OF TERMINALIA BELERICA
The research work was conducted with the fruits of Terminalia belerica (Fam: Combretaceae) to investigate antibacterial & antifungal activities. The fruits of the plant were successively extracted by cold extraction process by using two solvents namely ethanol and acetone. Antimicrobial activities of the extracts of both solvents were investigated by a simple agar diffusion method using ten pa...
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ISOLATION AND CHARACTERISATION OF A NEW ALLELOCHEMICAL FROM PARTHENIUM HYSTEROPHORUS L.
Parthenium hysterophorus L. is commonly known as “Gajar ghas" in Hindi and belongs to family Composite. It is an annual herb erect up to 1.5 m in hight. Its stems is branched and covered with trichomes. Its leaves are pale green, branched and covered with soft fine hairs. In Homoeopathy system, allergies caused by Parthenium can be treated by a drug prepared from Parthenium. Root decoction ...
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CONCEPTS OF ANTI-HIV THERAPY & ITS APPLICATIONS IN RESOURCE POOR SETTINGS
HIV since its invention has become global burden. In last two decades of the HIV prevalence many anti-retroviral drugs have been developed. Poor countries like India have started central government funded programmes to tackle the menace of the HIV. These programmes have been started because many people cannot afford costly ART drugs. In this review article, we have discussed current ART regimens a...
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