Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
SYNERGISM BETWEEN CASSIA FISTULA AND FLUCONAZOLE; “A NEW APPROACH AGAINST CANDIDIASIS”
Natural products have great potential against microbes and can be used to overcome the problem of drug resistant pathogens. They are helpful in reducing the toxicity of existing antifungal compounds. This present in vitro study demonstrated the synergistic effectiveness of Cassia fistula (CF) leaves extracts and fluconazole (Flu) against isolated Flu resistant strains (FRSs) of Candida albicans (C...
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DEVELOPMENT AND CHARACTERIZATION OF SOLID LIPID NANOPARTICLES BY SOLVENT DIFFUSION- EVAPORATION METHOD FOR TOPICAL DELIVERY
The aim of the present study was to prepare solid lipid nanoparticles (SLNs) for the topical delivery. Tristearin was used as solid lipid with soya lecithin by using surfactant, Poloxamer 188 (1%) and Tween 80 (0.5%). Solid lipid nanoparticles (SLN) loaded with Flucanazole were prepared by solvent diffusion- emulsification method. The properties of the SLNs such as particle size, zeta potential (Z...
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IN-VITRO PROPAGATION OF TYLOPHORA OVATA (LIND.) HOOK. EX. STEUD – AN IMPORTANT MEDICINAL PLANT
Efficient in-vitro propagation of Tylophora ovata (Lind.) Hook. Ex. Steud was carried out in this present investigation. Nodal segments from the healthy grown plants were used as explants for culturing. Explants were cultured on standard Murashige and Skoog (MS) medium supplemented with different concentration of benzyl amino purine (BAP) and naphthalene acetic acid (NAA) for primary shoot pro...
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MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEM – A COMPREHENSIVE AND PROMISING NOVEL DRUG DELIVERY
Since Dr. Tsuneji Nagai of Hoshi University, Japanin the early 1980’s used the concept of bio adhesion for the delivery of insulin across the buccal mucosa in beagle dogs; several researchers tried a large number of drugs for administration through buccal mucoadhesive dosage forms. The potential of these dosage forms have been found to be tremendous because of their ability to improve the bioava...
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A STUDY ON FEASIBILITY OF OPTIMIZATION TECHNIQUE IN FORMULATION OF DISPERSIBLE TABLETS BY FACTORIAL DESIGN
In the present research work an attempt was made to study the effect of formulation variables in the development of dispersible tablet by using various super disintegrants. Instead of normal trial and error method an optimization technique was adapted. Amount of Crosscarmellose sodium, SSG and MCC were included as independent variables and hardness, percentage friability, disintegration time and w...
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NEW SIMPLE RP-HPLC METHOD FOR THE ESTIMATION OF SILDENAFIL CITRATE IN PHARMACEUTICAL DOSAGE FORM
A new simple, rapid, accurate, precise and sensitive RP-HPLC method was developed for the estimation of sildenafil citrate in bulk and pharmaceutical dosage form. The separation of sildenafil citrate was achieved on a Phenomenex C18 Column (150 X 4.6 mm i.d, 5µ particle size) with a mobile phase consisting of methanol and Buffer (50:50 % v/v). The flow rate was 1.5 ml/min and photodiode array det...
5395
1802
SYNTHESIS OF NOVEL HESPERETIN OXIME ESTERS: A NEW DISCERNMENT IN TO THEIR ANTIOXIDANT POTENTIAL
A series of novel hesperetin oxime esters (3a-l) were synthesized and there in vitro antioxidant potential was examined. Hesperetin oxime 2 was furnished by oximation of hesperetin then subsequently upon esterification with substituted benzoyl chlorides to obtain hesperetin oxime esters (3a-l) in good yields. The structure of compounds was elucidated by elemental analysis, IR, NMR (1H, 13C) and ...
4395
1754
FORMULATION AND EVALUATION OF GASTRORETENTIVE DELIVERY OF TIZANIDINE HYDROCHLORIDE USING NATURAL POLYMERS
The present investigation concerns the design and evaluation of floating tablets of Tizanidine hydrochloride, which after oral administration are designed to prolong the gastric residence time and increased drug bioavailability. It is a centrally acting α2 adrenergic agonist. It is used in the treatment of migraine headaches, spasms and anticonvulsant. The dosage was designed by using natural pol...
4677
1880
PHYTOCHEMICAL SCREENING AND ANTIOXIDANT POTENTIAL OF ROOT OF MENTHA ARVENSIS L. FROM KASHMIR REGION
To evaluate phytochemical constituents and antioxidant potential of aqueous and hydroalcoholic extracts of root of Mentha arvensis L from Kashmir region. The antioxidant activity of aqueous and hydroalcoholic extracts of Mentha arvensis L was evaluated by using 1, 1-diphenyl, 2-picrylhydrazyl (DPPH) scavenging, reducing power, metal chelating, hydrogen peroxide scavenging and nitrous oxide scave...
4748
1779
A PHARMACOPHORE BASED DRUG DESIGN APPROACH TO OVERCOME IMATINIB RESISTANCE AND GET MORE POTENT BCR-ABL TYROSINE KINASE INHIBITOR
BCR-ABL Tyrosine Kinase inhibitor is an ideal pharmacological target for Chronic Myeloid Leukemia (CML). After the effective use of Imatinib as a therapeutic agent for Chronic Myeloid Leukemia, resistance has been observed in much patience with the treatment of Imatinib. The main objective of this study is to develop some new novel BCR-ABL Tyrosine Kinase inhibitor for the treatment of Chronic Mye...
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