Adhatoda vasica Nees. has been used in India for more than 2000 years. The drug contains leaf, stem, flower, fruit and seeds. The fruit which holds the most potentialof the herb is a small capsule with four seeds. No reports are available for the pharmacognostical study of the seed, hence the present study was undertaken to investigate the macroscopic, microscopic, powder microscopic, physicochemi...
OPTIMIZATION OF TELMISARTAN TABLET FORMULATION BY 23 FACTORIAL DESIGN EMPLOYING βCD, PRIMOJEL AND TWEEN 80
The objective of the present study is optimization of telmisartan tablet formulation employing βCD, Primojel, and Tween 80 by 23 factorial design to achieve NLT 85% dissolution in 10 min. Eight telmisartan tablet formulations were prepared using selected combinations of the three factors as per 23 factorial design. Telmisartan tablets were prepared by direct compression method and were evaluated....
THERMAL AND STRUCTURAL PROPERTIES OF IRRADIATED SILVER/POLY (VINYL ALCOHOL) (Ag/PVA) NANOCOMPOSITES USING ARGON ION BEAM
Structural and thermal properties of silver/poly(vinyl alcohol) (Ag/PVA) nanocomposites has been investigated as a function of Argon ion beam fluence. The XRD patterns (X-ray diffraction) showed the formation of the Ag/PVA in polymer structure and phase analysis with different sizes as a function of either ion beam fluence or Ag+ ion molar concentrations. The kinetic parameters for the thermal s...
Norepinephrine (NE) is an important catecholamine neurotransmitter that acts as a biochemical messenger in central nervous systems and neuronal cells of mammals, which is secreted and released by the adrenal medulla and the noradrenergic neurons during the synaptic transmission. It is often used for treating bronchial asthma, myocardial infarction hypertension and organic heart disease. Abnormal r...
Background: The relation between Chronic Kidney Disease (CKD) and cognitive impairment is an important public health issue because the prevalence of CKD is increased worldwide. In recent years, chronic kidney disease has been proposed as an independent risk factor for cognitive decline but the available data are conflicting. In the present study, we examined the relations of CKD and lower renal fi...
IMPACT OF DIFFERENT CARBON SUPPLEMENT ON EXTRACTION OF C-PHYCOCYANIN (C-PC) FOLLOWED BY POLY-β-HYDROXYBUTYRATE (PHB) FROM NOSTOC MUSCORUM
The extraction of poly-β-hydroxybutyrate (PHB) and C-phycocyanin (C-PC) from Nostoc muscorum revealed that PHB yield after C-PC extraction was not found differ significantly as without C-PC extraction. Under photoautotrophic growth condition, the test cyanobacterium accumulates PHB and C-PC with a maximum yield of 40 and 57 mg l-1 respectively at the stationary phase, i.e. on day 21 of incubation...
Background: Antiaris toxicaria is a tree in the mulberry and fig family of Moraceae. The leaf is used to remedy various ailments but the preparation depends on individuals. There is a need to set a standard for its preparation that would ensure optimum therapeutic benefits. Medicinal plants are generally reputed as cheaper and safer alternatives to synthetic drugs but these are often adulterated...
OPTIMIZATION OF TETRABENAZINE TABLET FORMULATION TO MEET THE REQUIRED DISSOLUTION PROFILE AND CONTENT UNIFORMITY
An approach to determine the relationship between independent process variables and their two level four factor partial factorial design was adopted, composite of experiment design was applied to optimize a tablet formulation of Tetrabenazine (TBZ) Tablets 25mg containing high percentage of Lactose Anhydrous, Sodium starch Glycolate, Magnesium Stearate and Starch / Lactose Ratio. The particle size...
ANTIBACTERIAL ACTIVITY OF NIGELLA SATIVA L. SEED OIL IN WATER EMULSION AGAINST DENTAL CARIOGENIC BACTERIA
Our previous study highlighted the antimicrobial activity evaluation of Nigella sativa seed oil extract that was obtained from supercritical fluid extraction using carbon dioxide (SCFE-CO2) on Gram positive pathogenic bacteria. The aim of this study was to formulate oil-in-water (o/w) emulsion of previous N. sativa seed oil extract and to investigate its antimicrobial activity against Streptococcu...
Cyclic adenosine monophosphate (cAMP) dependent protein kinase plays a major role in cell signaling pathway. Over expression of extracellular cAMP dependent protein kinase catalytic subunit caused tumorgenesis in prostate. This protein may provide a base for the design of clinically applicable therapeutic strategies. In order to develop potential inhibitor of cAMP dependent protein kinase catalyti...