Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
NOVEL SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 3-AMINO PHENYL-5-METHYL PYRAZOLES AND ITS DERIVATIVES
Pyrazoles and fused heterocyclic pyrazoles derivatives constitute an interesting class of heterocyclic compounds due to their synthetic versatility and effective biological activity in the field of pharmaceutical science, agriculture etc. In the present study, new substituted pyrazoles were prepared by condensation of substituted primary amine and ethyl acetoacetate at 1400C to form analides as ...
3211
1222
PROTECTIVE PROFILE OF HYDNOCARPUS LAURIFOLIA ON STREPTOZOTOCIN INDUCED OXIDATIVE STRESS IN RATS
The present study was aimed to evaluate the anti-oxidative defence system of Hydnocarpus laurifolia in diabetic rats and its potential effect against the β-cell damage induced by oxidative stress. Hydnocarpus laurifolia is a plant which belongs to the family Flacourtiaceae. According to the Indian system of traditional medicine it is used in the treatment of diabetes mellitus. Also literature rev...
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BIOLOGICAL ACTIVITY EVALUATION OF NOVEL N-HETEROCYCLIC CARBENE PRECURSORS
Five novel benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) precursors (1a-e). They were characterized by different techniques. The antimicrobial activities of these compounds were tested. The compounds showed moderate activity against three Gram (+) and seven Gram (-) bacteria in comparison to tetracycline, which was used as the standard antibiotic, whereas all the compounds...
3139
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ESTIMATION OF QUERCETIN BY HIGH PERFORMANCE CHROMATOGRAPHY AND ANTIFUNGAL ACTIVITY OF MOSS PHILONOTIS REVOLUTA
Bryophytes- the small, slow growing group of plants is stockroom of naturally occurring materials. They contain a high number of biologically active compounds, however their use as a natural fungicides is negligible. In the recent years bryophytes has emerged as a potential biopharming tool for production of complex biopharmaceutiticals. In order to evaluate potential use of bryophytes as an antif...
3009
1222
DEVELOPMENT AND IN VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF DICLOFENAC SODIUM USING DIFFERENT GRADE HYDROPHILIC POLYMER & PEG 6000 AS RELEASE RETARDANT
Diclofenac Sodium, being NSAID, its oral administration restricted due to its inherent problems. Hence in the present study, attempt has been made to design oral sustained release once daily matrix tablets of Diclofenac Sodium using combination of hydroxyl propyl methyl cellulose (HPMC) & PEG 6000 and to study the effect of various process and formulation variables like polymer properties and ...
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1214
SYNTHESIS, CHARACTERIZATION & BIOLOGICAL STUDIES OF NEWER CLASS OF QUNINOLONE DERIVATIVES
Background: Antimicrobials are used for bacterial infections & has a great benefits in health related problems of human life. The main objectives of medicinal chemistry is synthesising and producing newer molecules having a valuable significant therapeutic action. Quinolones has a considerable scientific and clinical interest since their discovery. Objective: Quinolones class of drugs are usef...
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COMPUTATIONAL PREDICTION OF BLOOD-BRAIN PARTITIONING OF DRUGS
Increasing use of bioinformatics made very easy to researchers in biological and drug discovery field. Bioinformatics is involved at each and every step of drug discovery to drug development. The first step of the drug discovery is a question about disease and the treatment by drugs and whenever term drug comes, means something has to be given and the second question arises the given compound is d...
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1031
A COMPARATIVE ANTIMICROBIAL EVALUATION OF EMBELIARIBES BURM. F. AND EMBELIAROBUSTA AUCT. NONROXB. FRUITS
Background: Vidang (Embelia ribes Burm. f.) is a very famous plant for its anthelmintic activity. In Ayurveda, it is a first choice of drug for its krimighna action or to kill foreign pathogens. Embeliaro busta auct. Nonroxb., the other species of vidang is adulterated in Embelia ribes Burm. f. Therefore shastrokta or original vidang and its adulterant species were selected for the comparative stu...
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THE NEWER DIMENSION OF INHALATION AEROSOLS IN THE PROSPECTIVE OF VALIDATION
Aerosol drug delivery systems are much more importance in present days and have much advantage over other route of administration. Meter dose inhaler was used to deliver asthma medication in easy way and reliable multi dose preparation. The importance of the MDIs device play important role in determining drug delivery to the lungs. The word validation means,” Impose of validation or action of pr...
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A PROMISING ANTINEOPLASTIC DRUG – METFORMIN (AN AMPK ACTIVATOR) FOR THE FUTURE
Metformin, an AMPK activator, acts as an oral hypoglycaemic agent. It reduces the risk of cancer during the treatment of diabetes and diabetes associated cancers. The effect of metformin on different type of cancers is explained on the pathway of AMPK activation involving hepatic fatty acid oxidation, inhibition of triglyceride and cholesterol synthesis and also modulation of insulin secretion. Th...
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