EFFECT OF AZADIRACHTA INDICA ON HYPERGLYCEMIA INDUCED OXIDATIVE STRESS IN ALLOXAN DIABETIC RAT BRAIN
The present study evaluates antidiabetic effect of A. indica leaf extract (AILE) and A. indica bark extract (AIBE) on antioxidant enzymes in the brain of alloxan diabetic rats and compared with insulin treatment. The oral effective dose of A. indica leaf (500mg/Kg body weight) and A. indica bark (100mg/Kg body weight) was given once daily for 21days to separate groups of diabetic rats. At the end ...
DRUG UTILIZATION STUDY OF ANTIHYPERTENSIVE TREATMENT BEING PRESCRIBED IN PATIENTS COMING TO MEDICINE OPD OF A TERTIARY CARE HOSPITAL IN NORTHERN INDIA
Introduction: Hypertension, is a global public health issue. It is a significant contributor to rising morbidity and mortality because of its associations with cardiovascular, renal and cerebrovascular complications. Given the prevalence and impact of the disease on health care a drug utilization study becomes essential to determine the current drug utilization pattern. Materials and Methods: 127 ...
UV-SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF LORNOXICAM AND EPERISONE HYDROCHLORIDE IN BULK DRUG, FORMULATIONS AND AQUEOUS DISSOLUTION SAMPLES
Lornoxicam has been found to be not interacted by eperisone hydrochloride at 377 nm. Therefore, it is estimated directly as a single component in the mixture, whereas eperisone hydrochloride is throughout interfered with by lornoxicam in UV region. So, it was estimated in the mixture using a two-wavelength difference method. Lornoxicam was found to have same absorbance at 262 nm and 283 nm but not...
DESIGN, SYNTHESIS AND MOLECULAR DOCKING STUDIES ON NOVEL CINNOLINE DERIVATIVES AS POTENTIAL ANTITUBERCULOSIS AGENTS
The emerging need for the multidrug regimen of M. tuberculosis strains urged us to synthesize novice and potent anti-tubercular medicaments. Our interest in this work had afforded a series of novice cinnolines as a new structural category of antituberculosis agents. All 14 compounds were synthesized using the appropriate scheme, two-step reactions with the high yielding product. The newly synthesi...
ALTERATIONS IN PLASMA ANTIOXIDANT ENZYME LEVELS AND SERUM LIPID PROFILE PARAMETERS IN RELATION TO LIPID PEROXIDATION IN INDIVIDUALS WITH MATERNALLY INHERITED TYPE 2 DIABETES MELLITUS
Aim: The present study aimed to evaluate the antioxidant potential and lipid profile parameters, in relation to lipid peroxidation in patients with maternally inherited type 2 diabetes mellitus and in healthy normal individuals. Methods: All standard methods were used to estimate enzymatic antioxidants [Catalase, Copper containing Superoxide Dismutase (CuSOD), Manganese containing Superoxide Dismu...
The aim of this study was to formulate and evaluate nine formulations of Gefitinib loaded PLGA nanoparticles by homogenization followed by solvent evaporation technique by use of biodegradable and biocompatible polymer i.e. PLGA. The effect of different concentrations of polymer and stabilizer (PVA) on particle size, zeta potential, %EE and drug release was studied. PLGA was used in different conc...
Cognitive functions are mainly categorized into memory, attention, creativity, and intelligence. Cognitive enhancement may be defined as the amplification or extension of core capacities of the mind. Phenylethylamine is an organic compound which is also known as β-phenylethylamine (β-PEA) and is the name of a class of chemicals which shows psychoactive and stimulant effects. It is a trace amine ...
A new flavone glycoside 1 m. p. 223-225ºC, m. f. C34H42O20, [M+] 770 (FABMS) has been isolated from the stems of Taraxacum Officinal weber along with one known compound Taxifolin. A compound 1 was characterized as 6, 4′-dimethoxy-5, 7-dihydroxy-flavone- 7 - O - a - L-rhamnopyranosyl-(1®4) - O – β - D xylopyranosyl-(1®4)-O-β-D-glucopyranoside by various chemical degradations and spectral a...
Osmosis is physical phenomenon that has been comprehensively studied by scientist in various disciplines of science and engineering. Osmotic devices are the most promising strategy based system for controlled delivery of drug. Conventional drug delivery has little control over their drug release and almost no control over the effective concentration at the target site. This kind of dosing pattern ...
SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL 1,8-NAPHTHYRIDINES CONTAINING PYRAZOLINONE, PYRAZOLE, ISOXAZOLINONE, ISOXAZOLE AND PYRIMIDINE-2-ONES
Diazonium salt of 2-(p-aminophenyl)-1,8-naphthyridine (I) was coupled with active methylene compounds to afford the hydrazono-1,8-napthyridinyl (III-V) and azo(VI) derivatives. Hydrazono ethyl acetoacetate (III) and ethyl cyanoacetate (IV) derivatives on treatment with hydrazine and substituted hydrazine’s were later reacted with hydroxylamine HCl in the presence of ethanol followed by cycliza...