The present study deals with formulation of a combined analgesic and antacid effervescent tablets. Paracetamol is the model drug used. It is poorly soluble in the water and hence the formulation is in the form of an effervescent tablet so that the disintegration time of the drug is not hindering the action. The mixture of magnesium and aluminium hydroxide is used as the model antacid. The present ...
EVALUATION OF TOTAL PHENOLICS, FLAVONOID CONTENTS AND IN-VITRO ANTIOXIDANT PROPERTIES OF CATHARANTHUS PUSILLUS (APOCYNACEAE)
Objective: Present study was aimed to evaluate the total phenolic, flavonoid content and in vitro antioxidant activity of petroleum ether, benzene, ethyl acetate, methanol and ethanol extracts of whole plant of Catharanthus pusillus. Methods: Antioxidant activity have been tested using various antioxidant model systems viz., DPPH, hydroxyl, superoxide, ABTS and reducing power. Results: Methanol ex...
THE UNDERSTANDING AND ADHERENCE OF HIV-INFECTED PREGNANT WOMEN TO THERAPY IN A SOUTH-EASTERN STATE OF NIGERIA: A CROSS-SECTIONAL ASSESSMENT
Introduction: Appropriate understanding and adherence to antiretroviral regimens are important requisites to the presentation of good outcomes in the Prevention of Mother-to-Child Transmission (PMTCT) of HIV/AIDS. Objectives: This study aimed to evaluate the understanding and level of adherence to antiretroviral regimens among HIV-infected pregnant women. The factors that affect the level were als...
Numerous carbazole derivatives were designed by the Chemsketch software followed by 3D optimization. Docking studies were performed using AUTODOCK 4.2.6 software to check their binding interactions with eukaryotic topoisomerase-I, based on the crystal structure of Human Topoisomerse-I-DNA complex (PDB ID: 1A35). Results of docking studies of designed carbazole derivatives were compared on the ba...
EVALUATION OF IN-VITRO ANTIOXIDANT AND ANTICANCER ACTIVITY OF MONOCHORIA VAGINALIS LEAVES ON Hep2 AND HeLa CELL LINES
The entire plant (Monochoria vaginalis (Burm. f.) C. Presl.) except root is being used as a vegetable and has been used in traditional Indian system of medication for treating various diseases. But there are not many scientific data on the antioxidant and anticancer activity of M. vaginalis. Therefore, we aimed to determine the in-vitro antioxidant and anticancer activity of methanolic extract of ...
The scenario of pharmaceutical drug delivery are expeditiously challenging, but conventional pharmaceutical dosage forms are still dominating. Immediate release dosage forms are those wherein ≥85% of labeled amount dissolves within 30 min. Superdisintegrants are used to improve the efficacy of solid dosage forms. The basic approach used in the formulation of the tablet is the use of superdisinte...
SIMULTANEOUS QUANTITATION AND VALIDATION OF PHENYLEPHRINE HYDRO-CHLORIDE, AMBROXOL HYDROCHLORIDE AND LEVOCITRIZINE HYDROCHLORIDE IN SYRUP FORMULATION BY REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
A simple, precise and accurate RP-HPLC method was developed and validated for the estimation of Phenylephrine hydrochloride, Ambroxol hydrochloride and Levocetirizine hydrochloride in syrup formulation. This method is based on HPLC separation of the three drugs on Octadecyl Silane C18 column (250 mm × 4.6 mm, 5.0μ), with isocratic conditions and mobile phase containing 0.01M Sodium dihydrogen ph...
This project involves in the development of sustained release matrix tablets of Gemigliptin. Which is an oral anti-hyperglycemic agent designed for the management of non insulin dependent diabetes mellitus (NIDDM). The basic goal of therapy is to achieve a steady sate blood level that is therapeutically effective and non toxic for an extended period of time. The objective in dosage form design is ...
QUALITY CONTROL, CHEMICAL COMPOSITION AND ANTIOXIDANT ACTIVITY OF SOME MARKETED PEPPERMINT OIL SAMPLES
This work aimed to evaluate the quality of some commercial peppermint oil products available in the Egyptian market. Also, analysis of peppermint oil extracted from Mentha piperita L. leaves marketed in Egypt. Thus, quality control of both herb extracted and purchased oil products. Essential oils were analyzed using GC/MS, and the main ingredients of each peppermint oil sample were quantified. The...
ASSESSMENT OF ANTIHYPERTENSIVE DRUGS UTILIZATION PATTERN IN BUTAJIRA ZONAL HOSPITAL, BUTAJIRA TOWN, SOUTH ETHIOPIA
Background: Many factors contribute for prevalence of high blood pressure including poor treatment compliance, lack of access to health care and lack of physician adherence to therapeutics. In Ethiopia, routine health care report is incomplete and erratic and 90% individuals diagnosed with hypertension do not properly adhere to treatment. The present study was carried out to assess the antihyperte...