EFFECT OF ETHANOL EXTRACT FROM MORUS ALBA LEAVES SUPPLEMENTATION ON GASTRIC TISSUE GLUTATHIONE LEVEL IN INDOMETHACIN INDUCED ULCERS IN RATS
Context: The leaves Morus alba have been traditionally used in Asian countries for treatment of different ailments. Objective: Present study was undertaken to evaluate the effect of ethanol extract from Morus alba leaves supplementation on gastric tissue glutathione level in indomethacin induced ulcers in rats. Materials and Methods: Ethanol extract from Morus alba leaves were administered at the ...
A STUDY ON SEROPOSITIVITY OF PLASMODIUM FALCIPARUM AND PAN MALARIAL SPEICES AMONG FEBRILE PATIENTS ATTENDING MIMS GENERAL HOSPITAL, NELLIMARLA, VIZIANAGARAM BY USING PARAHIT TOTAL RAPID TEST KIT METHOD.
Malaria, at one time a rural disease, diversified under the pressure of developments into various ecotypes. These ecotypes have been identified as forest malaria, urban malaria, rural malaria, industrial malaria, border malaria and migration malaria; the latter cutting across boundaries of various epidemiological types. In the present study, an attempt has been made to know the seropositivity of P...
FORMULATION AND EVALUATION OF GASTRO RETENTIVE MATRIX TABLETS OF ATENOLOL USING MELT GRANULATION TECHNIQUE
The main objective of this present work was to develop and evaluate matrix tablets of Atenolol by melt granulation technique and compare the drug release between bess wax and glyceryl monostearate (GMS). Polymers like HPMC K 4 M, HPMC K 100 M, bees wax, glyceryl monostearate and ethyl cellulose were incorporated in the formulation. Formulations were prepared by keeping the HPMC and ethyl cellulose...
The present paper deals with the analysis of methane sulfonic acid, benzene sulfonic acid and camphor sulfonic acid counter anions in pharmaceutical ingredients (doxazosin mesylate, amlodipine besylate and clopidogrel camphor sulfonate) by suppressed conductivity anion chromatography. The diluent used for the preparation of sample solution was Milli-Q Water and injected into a standard chromatogra...
Hyperlipidemia is a common finding in uncontrolled Diabetes Mellitus (DM) and patients with DM generally show alteration in lipid profile, notably in triglycerides value. Research done in the past has pointed out the usefulness of Atherogenic Index of Plasma (AIP) as a useful parameter for the diagnosis of Type 2 DM. HbA1c is well established as gold standard to monitor long term diabetic control....
Non-alcoholic steatohepatitis (NASH) is a metabolic disorder of the liver that may progress to fibrosis or cirrhosis. In the present study, we examined the possible preventive effect of an extract of Teucrium polium L. (Lamiaceae), a plant with high flavonoid content and antioxidant activity, on experimental NASH. To induce NASH, a methionine and choline deficient (MCD) diet was given to N-Mary ra...
REASONS FOR PARTICIPATION AND PROBLEMS ENCOUNTERED BY HEALTHY VOLUNTEERS IN BIOAVAILABILITY / BIOEQUIVALENCE STUDIES
Bioavailability / Bioequivalence (BA/BE) studies are conducted as a part of regulatory requirement to establish that the generic drugs are equivalent to the innovator drugs and are usually carried out in healthy human volunteers. They are nontherapeutic studies without any direct benefit to the participants. In spite of the lack of any direct personal benefit what makes some individuals to volunte...
ASSESSMENT OF VITAMIN D ON METABOLIC DISORDERS IN ARTHRITIC PREDIABETIC PATIENTS- A PHARMACOLOGICAL APPROACH
We planned to clarify the association between the Vitamin D supplementation and predisposition of metabolic syndrome including obesity, diabetes mellitus, hypertension and dyslipidemia in arthritic patient with pre diabetic condition and to assess prediabetes interfere in the disease progression. Retrospective observational study was conducted on 236 patients. Of these, Arthritis patients with no ...
INFLUENCE OF FLUCONAZOLE PRE-TREATMENT ON ANTIDIABETIC ACTIVITY OF THIAZOLIDINEDIONES IN DIABETIC RATS
The influence of fluconazole pre-treatment on the hypoglycaemic effect of pioglitazone (10 mg/kg, p.o) and rosiglitazone (720µg/kg, p.o) was studied. This study was conducted on diabetic rats of either sex, randomly distributed into two different groups. Diabetes was induced by administering 120mg/kg of alloxan intraperitonially. Then they were pretreated with fluconazole (36 mg/kg) in 2% w/v gum...
SYNTHESIS, CHARACTERIZATION AND IN VITRO ANTICANCER EVALUATION OF BIS-[1,5]-BENZOTHIAZEPINES AGAINST HUMAN BREAST CANCER CELL LINE MCF-7
Bis-[1,5]-benzothiazepines (3a-i) containing two 1,5-benzothiazepine nuclei in a single molecule were synthesized by cyclocondensation reaction of bis-chalcones (1a-i) with two equivalent of 2-aminobenzenethiol (2). All the synthesized compounds were characterized by IR, 1H NMR,13C NMR and mass spectral analysis. Anticancer activity of the synthesized compounds against human breast cancer cell lin...